Search Results - "DE MEESTER, Ingrid"

Anti-inflammatory effects on ischemia/reperfusion-injured lung transplants by the cluster of differentiation 26/dipeptidylpeptidase 4 (CD26/DPP4) inhibitor vildagliptin by Jang, Jae-Hwi, PhD, Yamada, Yoshito, MD, PhD, Janker, Florian, MSc, De Meester, Ingrid, PhD, Baerts, Lesley, PhD, Vliegen, Gwendolyn, MSc, Inci, Ilhan, MD, Chatterjee, Shampa, PhD, Weder, Walter, MD, Jungraithmayr, Wolfgang, MD, PhD

“…Abstract Objectives We showed previously that stromal cell−derived factor 1 (SDF-1) is a substrate of cluster of differentiation 26/dipeptidylpeptidase 4…”
Get full text

CD26/DPP4 - a potential biomarker and target for cancer therapy by Enz, Njanja, Vliegen, Gwendolyn, De Meester, Ingrid, Jungraithmayr, Wolfgang

“…CD26/dipeptidyl peptidase (DPP)4 is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is…”
Get full text

Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases by Ceuleers, Hannah, Van Spaendonk, Hanne, Hanning, Nikita, Heirbaut, Jelena, Lambeir, Anne-Marie, Joossens, Jurgen, Augustyns, Koen, De Man, Joris G, De Meester, Ingrid, De Winter, Benedicte Y

“…Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role…”
Get full text

Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile) by Brandt, Inger, Joossens, Jurgen, Chen, Xin, Maes, Marie-Berthe, Scharpé, Simon, Meester, Ingrid De, Lambeir, Anne-Marie

“…Vildagliptin (NVP-LAF237/(2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile) was described as a potent, selective and orally…”
Get full text

Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators by Moon, Euy Sung, Elvas, Filipe, Vliegen, Gwendolyn, De Lombaerde, Stef, Vangestel, Christel, De Bruycker, Sven, Bracke, An, Eppard, Elisabeth, Greifenstein, Lukas, Klasen, Benedikt, Kramer, Vasko, Staelens, Steven, De Meester, Ingrid, Van der Veken, Pieter, Rösch, Frank

“…Background Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other…”
Get full text

Regulation of intestinal permeability: The role of proteases by Van Spaendonk, Hanne, Ceuleers, Hannah, Witters, Leonie, Patteet, Eveline, Joossens, Jurgen, Augustyns, Koen, Lambeir, Anne-Marie, De Meester, Ingrid, De Man, Joris G, De Winter, Benedicte Y

“…The gastrointestinal barrier is - with approximately 400 m - the human body's largest surface separating the external environment from the internal milieu…”
Get full text

The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis by Waumans, Yannick, Baerts, Lesley, Kehoe, Kaat, Lambeir, Anne-Marie, De Meester, Ingrid

“…Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its family members in many processes and different pathologies of the…”
Get full text

Dipeptidyl peptidase 4 as a therapeutic target in ischemia/reperfusion injury by Matheeussen, Veerle, Jungraithmayr, Wolfgang, De Meester, Ingrid

“…Dipeptidyl peptidase 4 (DPP4, DPPIV, CD26, EC 3.4.14.5) was discovered more than four decades ago as a serine protease that cleaves off N-terminal dipeptides…”
Get full text

Stability, enrichment, and quantification of total and HPV16-specific IgG present in first-void urine by Téblick, Laura, Lipovac, Marijana, Bell, Margo, De Smet, Annemie, De Meester, Ingrid, Delputte, Peter, Vorsters, Alex

“…First-void urine (FVU) samples, containing human papillomavirus (HPV)-specific IgG from female genital tract secretions, provide a non-invasive option for…”
Get full text

The CD26/DPP4-inhibitor vildagliptin suppresses lung cancer growth via macrophage-mediated NK cell activity by Jang, Jae-Hwi, Janker, Florian, De Meester, Ingrid, Arni, Stephan, Borgeaud, Nathalie, Yamada, Yoshito, Gil Bazo, Ignacio, Weder, Walter, Jungraithmayr, Wolfgang

“…Abstract CD26/dipeptidyl peptidase 4 (DPP4) is a transmembrane protein which is expressed by various malignant cells. We found that the expression of CD26/DPP4…”
Get full text

ProCPU Is Expressed by (Primary) Human Monocytes and Macrophages and Expression Differs between States of Differentiation and Activation by Claesen, Karen, De Loose, Joni, Van Wielendaele, Pieter, De Bruyn, Emilie, Sim, Yani, Thys, Sofie, De Meester, Ingrid, Hendriks, Dirk

“…Carboxypeptidase U (CPU, TAFIa, CPB2) is a potent attenuator of fibrinolysis that is mainly synthesized by the liver as its inactive precursor proCPU. Aside…”
Get full text

DPP IV inhibitor treatment attenuates bone loss and improves mechanical bone strength in male diabetic rats by Glorie, Lorenzo, Behets, Geert J, Baerts, Lesley, De Meester, Ingrid, D'Haese, Patrick C, Verhulst, Anja

“…Dipeptidyl peptidase IV (DPP IV) modulates protein activity by removing dipeptides. DPP IV inhibitors are currently used to improve glucose tolerance in type 2…”
Get more information

Prolyl Carboxypeptidase Activity Is Present in Human Adipose Tissue and Is Elevated in Serum of Obese Men with Type 2 Diabetes by De Hert, Emilie, Verboven, Kenneth, Wouters, Kristiaan, Jocken, Johan W. E., De Meester, Ingrid

“…Prolyl carboxypeptidase (PRCP) is involved in metabolic disorders by hydrolyzing anorexigenic peptides. A link between serum PRCP activity and obesity has been…”
Get full text

Biotransformation of three phosphate flame retardants and plasticizers in primary human hepatocytes: untargeted metabolite screening and quantitative assessment by Van den Eede, Nele, de Meester, Ingrid, Maho, Walid, Neels, Hugo, Covaci, Adrian

“…Tris(2‐butoxyethyl) phosphate (TBOEP), triphenyl phosphate (TPHP) and tris(1‐chloro‐2‐propyl) phosphate (TCIPP) are current high‐volume organophosphate flame…”
Get full text

Prolyl Carboxypeptidase Mediates the C-Terminal Cleavage of (Pyr)-Apelin-13 in Human Umbilical Vein and Aortic Endothelial Cells by De Hert, Emilie, Bracke, An, Pintelon, Isabel, Janssens, Eline, Lambeir, Anne-Marie, Van Der Veken, Pieter, De Meester, Ingrid

“…The aim of this study was to investigate the C-terminal cleavage of (pyr)-apelin-13 in human endothelial cells with respect to the role and subcellular…”
Get full text

DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury by Glorie, Lorenzo L F, Verhulst, Anja, Matheeussen, Veerle, Baerts, Lesley, Magielse, Joanna, Hermans, Nina, D'Haese, Patrick C, De Meester, Ingrid, De Beuf, Annelies

“…Dipeptidyl peptidase 4 (DPP4) is an exopeptidase which modulates the function of its substrates, among which are insulin-releasing incretins. DPP4 inhibitors…”
Get more information

Optimal Evaluation of Programmed Death Ligand-1 on Tumor Cells Versus Immune Cells Requires Different Detection Methods by Schats, Kelly A, Van Vré, Emily A, Boeckx, Carolien, De Bie, Martine, Schrijvers, Dorien M, Neyns, Bart, De Meester, Ingrid, Kockx, Mark M

“…- The benefit of programmed death ligand-1 (PD-L1) immunohistochemistry (IHC) as a method to select patients who may benefit from programmed death receptor-1…”
Get full text

Dysregulated activities of proline-specific enzymes in septic shock patients (sepsis-2) by Vliegen, Gwendolyn, Kehoe, Kaat, Bracke, An, De Hert, Emilie, Verkerk, Robert, Fransen, Erik, Jongers, Bart 's, Peters, Esther, Lambeir, Anne-Marie, Kumar-Singh, Samir, Pickkers, Peter, Jorens, Philippe G, De Meester, Ingrid

“…The proline-specific enzymes dipeptidyl peptidase 4 (DPP4), prolylcarboxypeptidase (PRCP), fibroblast activation protein α (FAP) and prolyl oligopeptidase…”
Get full text

CD26 costimulatory blockade improves lung allograft rejection and is associated with enhanced interleukin-10 expression by Yamada, Yoshito, MD, PhD, Jang, Jae-Hwi, PhD, De Meester, Ingrid, PhD, Baerts, Lesley, PhD, Vliegen, Gwendolyn, MSc, Inci, Ilhan, MD, Yoshino, Ichiro, MD, PhD, Weder, Walter, MD, Jungraithmayr, Wolfgang, MD, PhD

“…Background The ectoenzyme CD26/dipeptidyl peptidase 4 (DPP4) has costimulatory activity that contributes to T cell activation and proliferation. Here, we aimed…”
Get full text

Proteolytic Cleavage of Bioactive Peptides and Protease-Activated Receptors in Acute and Post-Colitis by De bruyn, Michelle, Ceuleers, Hannah, Hanning, Nikita, Berg, Maya, De Man, Joris G., Hulpiau, Paco, Hermans, Cedric, Stenman, Ulf-Håkan, Koistinen, Hannu, Lambeir, Anne-Marie, De Winter, Benedicte Y., De Meester, Ingrid

“…The protease activity in inflammatory bowel disease (IBD) and irritable bowel syndrome has been studied extensively using synthetic fluorogenic substrates…”
Get full text