Search Results - "DE MEDICIS, R"

Monosodium urate crystals promote neutrophil adhesion via a CD18-independent and selectin-independent mechanism by Reinhardt, P H, Naccache, P H, Poubelle, P E, de Médicis, R, Kehrli, Jr, M E, Kubes, P

“…The primary objective of this study was to determine whether monosodium urate (MSU) crystals induced neutrophil adhesion to cellular substrata and, if so, then…”
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Acute apatite podagra with negative birefringent spherulites in the synovial fluid by Beaudet, F, de Médicis, R, Magny, P, Lussier, A

“…We describe a young male patient who presented with acute podagra after jogging activity. He had no underlying pathology. Polarized light microscopy of the…”
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Reducing property of some slow acting antirheumatic drugs by Huck, F, de Médicis, R, Lussier, A, Dupuis, G, Federlin, P

“…Many slow acting antirheumatic drugs and several other drugs without antirheumatic activity possess a potential thiol function, i.e., a free SH group or one…”
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Acute polyarthritis associated with birefringent lipid microspherules occurring in a patient with longstanding rheumatoid arthritis by Rivest, C, Hazeltine, M, Gariepy, G, de Medicis, R

“…We describe a 52-year-old patient with longstanding rheumatoid arthritis (RA) who developed an acute polyarthritis of her hands and wrists. Synovial fluid…”
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Crystal-induced neutrophil activation. IV: Specific inhibition of tyrosine phosphorylation by colchicine by ROBERGE, C. J, GAUDRY, M, DE MEDICIS, R, LUSSIER, A, POUBELLE, P. E, NACCACHE, P. H

“…We recently demonstrated that pathologically relevant inflammatory microcrystals, namely triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate…”
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Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils by Ryckman, Carle, Gilbert, Caroline, Médicis, Rinaldo, Lussier, André, Vandal, Karen, Tessier, Philippe A.

“…The neutrophil cytoplasmic protein S100A8/A9 (along with S100A8 and S100A9) is chemotactic and stimulates neutrophil adhesion by activating the β2‐integrin…”
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Crystal-induced neutrophil activation. III: Inflammatory microcrystals induce a distinct pattern of tyrosine phosphorylation in human neutrophils by GAUDRY, M, ROBERGE, C. J, DE MEDICIS, R, LUSSIER, A, POUBELLE, P. E, NACCACHE, P. H

“…The activation of human neutrophils by monosodium urate and calcium pyrophosphate dihydrate crystals is believed to play a critical role in the pathogenesis of…”
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Adjuvant arthritis: influence of the adjuvant volume and composition on the established arthritis by Lussier, A, De Médicis, R, Tétreault, L

“…Adjuvant arthritis remains an interesting model for the evaluation of therapeutic agents and for the study of inflammatory mechanisms. The severity and time…”
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Phagocytosis of sodium urate and calcium pyrophosphate crystals by leukocytes of gouty, pseudogouty and health donors by de Médicis, R, Lussier, A, Kahan, A, Tétreault, L

“…The initial rates of oxygen consumption and of glucose oxidation via the hexose monophosphate shunt were measured during the phagocytosis of sodium urate and…”
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Correlation between ossification and inflammation using a rat experimental model by Lussier, A, de Medicis, R

“…In seronegative spondylarthropathies both inflammation and ossification can be demonstrated. Inflammation is a hallmark of diseases associated with antigen…”
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Inflammatory Microcrystals Alter the Functional Phenotype of Human Osteoblast-Like Cells In Vitro: Synergism with IL-1 to Overexpress Cyclooxygenase-2 by Bouchard, Line, de Medicis, Rinaldo, Lussier, Andre, Naccache, Paul H, Poubelle, Patrice E

“…Chronic crystal-associated arthropathies such as gout and pseudogout can lead to local bone destruction. Because osteoblasts, which orchestrate bone remodeling…”
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Inhibition of adjuvant arthritis in the rat by an oxonate diet: sequential studies by Lussier, A, de Medicis, R

“…To study the mechanism by which oxonate-induced hyperuricemia inhibits the development of adjuvant arthritis in the rat, we initiated blocking or releasing…”
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Monosodium urate and calcium pyrophosphate crystals differentially activate the excitation-response coupling sequence of human neutrophils by Poubelle, P E, De Medicis, R, Naccache, P H

“…The activation patterns of human neutrophils elicited by unopsonized monosodium urate and calcium pyrophosphate dihydrate crystals were investigated. The…”
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Adjuvant arthritis: influence of the adjuvant volume and composition on the non-specific inflammation by Lussier, A, de Médicis, R, Tétreault, L

“…Adjuvant-induced arthritis is an animal model of chronic inflammatory disease widely used in anti-inflammatory and immunosuppressive drugs testing. When the…”
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Slow onset anti-rheumatic drugs in rheumatoid arthritis: could the presence of antinuclear antibody influence the therapeutic results? by Menard, H A, Mathieu, J P, de Medicis, R, Lussier, A

“…The therapeutic value of sodium aurothiomalate, D-penicillamine and levamisole was evaluated in three comparable groups of 20 rheumatoid arthritis (RA)…”
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Paradoxical effects of colchicine on the activation of human neutrophils by chemotactic factors and inflammatory microcrystals by Roberge, C. J., Gaudry, M., Gilbert, C., Malawista, S. E., Médicis, R., Lussier, A., Poubelle, P. E., Naccache, P. H.

“…Neutrophil activation by chemotactic factors and by inflammatory microcrystals is accompanied by increases in protein tyrosine phosphorylation and by the…”
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Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins by Getting, S J, Flower, R J, Parente, L, de Medicis, R, Lussier, A, Woliztky, B A, Martins, M A, Perretti, M

“…Injection of monosodium urate (MSU) crystals, the etiological cause of gouty arthritis, into murine peritoneal cavities produced an intense recruitment of…”
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Crystal-induced neutrophil activation. II. Evidence for the activation of a phosphatidylcholine-specific phospholipase D by Naccache, P H, Bourgoin, S, Plante, E, Roberge, C J, de Medicis, R, Lussier, A, Poubelle, P E

“…To investigate the involvement of phospholipase D in the signaling pathways activated by 2 pathologically relevant inflammatory microcrystals, monosodium urate…”
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Inhibition of adjuvant-induced arthritis in the hyperuricemic rat by Lussier, A, de Medicis, R, Marquis, L, Menard, H

“…In man, there is a strong negative correlation between gout and rheumatoid arthritis. To investigate this apparent mutual exclusion, we studied the influence…”
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The use of a 51Cr technique to detect gastrointestinal microbleeding associated with nonsteroidal antiinflammatory drugs by Lussier, A, Arsenault, A, Varady, J, de Médicis, R, Lussier, Y, LeBel, E

“…Of techniques used to evaluate gastrointestinal (GI) bleeding, use of radiochromium (51Cr)-tagged erythrocytes is the most quantitative and scientifically…”
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