Search Results - "DE LORENZO, Mariana S"

Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration by Umemura, Masanari, Baljinnyam, Erdene, Feske, Stefan, De Lorenzo, Mariana S, Xie, Lai-Hua, Feng, Xianfeng, Oda, Kayoko, Makino, Ayako, Fujita, Takayuki, Yokoyama, Utako, Iwatsubo, Mizuka, Chen, Suzie, Goydos, James S, Ishikawa, Yoshihiro, Iwatsubo, Kousaku

“…Store-operated Ca(2+) entry (SOCE) is a major mechanism of Ca(2) (+) import from extracellular to intracellular space, involving detection of Ca(2+) store…”
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Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence by Tivari, Samir, Lu, Haiyan, Dasgupta, Tanya, De Lorenzo, Mariana S, Wieder, Robert

“…Dormant estrogen receptor positive (ER+) breast cancer micrometastases in the bone marrow survive adjuvant chemotherapy and recur stochastically for more than…”
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Gβγ subunits inhibit Epac-induced melanoma cell migration by Baljinnyam, Erdene, Umemura, Masanari, De Lorenzo, Mariana S, Xie, Lai-Hua, Nowycky, Martha, Iwatsubo, Mizuka, Chen, Suzie, Goydos, James S, Iwatsubo, Kousaku

“…Recently we reported that activation of Epac1, an exchange protein activated by cAMP, increases melanoma cell migration via Ca 2+ release from the endoplasmic…”
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Regulation of Mertk Surface Expression via ADAM17 and γ-Secretase Proteolytic Processing by Lahey, Kevin C, Varsanyi, Christopher, Wang, Ziren, Aquib, Ahmed, Gadiyar, Varsha, Rodrigues, Alcina A, Pulica, Rachael, Desind, Samuel, Davra, Viralkumar, Calianese, David C, Liu, Dongfang, Cho, Jong-Hyun, Kotenko, Sergei V, De Lorenzo, Mariana S, Birge, Raymond B

“…Mertk, a type I receptor tyrosine kinase and member of the TAM family of receptors, has important functions in promoting efferocytosis and resolving…”
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Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer by Kumar, Sushil, Davra, Viralkumar, E. Obr, Alison, Geng, Ke, L. Wood, Teresa, De Lorenzo, Mariana S., Birge, Raymond B.

“…The tumor infiltration of immune cells in solid cancers can profoundly influence host antitumor responses. In recent years, immunotherapeutic regimens, that…”
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Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism by BALJINNYAM, Erdene, DE LORENZO, Mariana S, XIE, Lai-Hua, IWATSUBO, Mizuka, CHEN, Suzie, GOYDOS, James S, NOWYCKY, Martha C, IWATSUBO, Kousaku

“…Melanoma has a poor prognosis due to its strong metastatic ability. Although Ca(2+) plays a major role in cell migration, little is known about the role of…”
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Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling by Baljinnyam, Erdene, Umemura, Masanari, Chuang, Christine, De Lorenzo, Mariana S., Iwatsubo, Mizuka, Chen, Suzie, Goydos, James S., Ishikawa, Yoshihiro, Whitelock, John M., Iwatsubo, Kousaku

“…Summary Fibroblast growth factor (FGF2) regulates endothelial and melanoma cell migration. The binding of FGF2 to its receptor requires N‐sulfated heparan…”
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Epac1 promotes melanoma metastasis via modification of heparan sulfate by Baljinnyam, Erdene, Umemura, Masanari, De Lorenzo, Mariana S., Iwatsubo, Mizuka, Chen, Suzie, Goydos, James S., Iwatsubo, Kousaku

“…Summary Our previous report suggested the potential role of the exchange protein directly activated by cyclic AMP (Epac) in melanoma metastasis via heparan…”
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Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity by Yan, Lin, Park, Ji Yeon, Dillinger, Jean‐Guillaume, De Lorenzo, Mariana S., Yuan, Chujun, Lai, Lo, Wang, Chunbo, Ho, David, Tian, Bin, Stanley, William C., Auwerx, Johan, Vatner, Dorothy E., Vatner, Stephen F.

“…Summary Adenylyl cyclase type 5 knockout mice (AC5 KO) live longer and are stress resistant, similar to calorie restriction (CR). AC5 KO mice eat more, but…”
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Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: Evidence for the role of epidermal growth factor receptor and its ligands by MORAITIS, Dimitrios, BAOHENG DU, DANNENBERG, Andrew J, DE LORENZO, Mariana S, BOYLE, Jay O, WEKSLER, Babette B, COHEN, Erik G, CAREW, John F, ALTORKI, Nasser K, KOPELOVICH, Levy, SUBBARAMAIAH, Kotha

“…Cyclooxygenase-2 (COX-2) is a promising pharmacologic target for preventing aerodigestive malignancies. In this study, we investigated the effects of tobacco…”
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Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer by Kasikara, Canan, Davra, Viralkumar, Calianese, David, Geng, Ke, Spires, Thomas E, Quigley, Michael, Wichroski, Michael, Sriram, Ganapathy, Suarez-Lopez, Lucia, Yaffe, Michael B, Kotenko, Sergei V, De Lorenzo, Mariana S, Birge, Raymond B

“…Tyro3, Axl, and Mertk (TAM) represent a family of homologous tyrosine kinase receptors known for their functional role in phosphatidylserine (PS)-dependent…”
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Axl and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Antitumor Immunity by Davra, Viralkumar, Kumar, Sushil, Geng, Ke, Calianese, David, Mehta, Dhriti, Gadiyar, Varsha, Kasikara, Canan, Lahey, Kevin C, Chang, Yun-Juan, Wichroski, Michael, Gao, Chan, De Lorenzo, Mariana S, Kotenko, Sergei V, Bergsbaken, Tessa, Mishra, Pankaj K, Gause, William C, Quigley, Michael, Spires, Thomas E, Birge, Raymond B

“…Despite the promising clinical benefit of targeted and immune checkpoint blocking therapeutics, current strategies have limited success in breast cancer,…”
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Caloric restriction reduces growth of mammary tumors and metastases by De Lorenzo, Mariana S, Baljinnyam, Erdene, Vatner, Dorothy E, Abarzúa, Patricio, Vatner, Stephen F, Rabson, Arnold B

“…We investigated the effects of caloric restriction (CR) on growth of tumors and metastases in the 4T1 mammary tumor model and found that CR, compared with…”
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Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis by ALONSO, D. F, FARINA, H. G, SKILTON, G, GABRI, M. R, DE LORENZO, M. S, GOMEZ, D. E

“…Lovastatin, a fungal antibiotic used in the treatment of hypercholesterolemia, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the key…”
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Calorie restriction can reverse, as well as prevent, aging cardiomyopathy by Yan, Lin, Gao, Shumin, Ho, David, Park, Misun, Ge, Hui, Wang, Chunbo, Tian, Yimin, Lai, Lo, De Lorenzo, Mariana S., Vatner, Dorothy E., Vatner, Stephen F.

“…Calorie restriction (CR) is the most widely studied intervention protecting from the adverse effects of aging. Almost all prior studies have examined the…”
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Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase by Kimani, Stanley G, Kumar, Sushil, Davra, Viralkumar, Chang, Yun-Juan, Kasikara, Canan, Geng, Ke, Tsou, Wen-I, Wang, Shenyan, Hoque, Mainul, Boháč, Andrej, Lewis-Antes, Anita, De Lorenzo, Mariana S, Kotenko, Sergei V, Birge, Raymond B

“…Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when…”
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Sexual dimorphism in cardiac triacylglyceride dynamics in mice on long term caloric restriction by Banke, Natasha H, Yan, Lin, Pound, Kayla M, Dhar, Sunil, Reinhardt, Heather, De Lorenzo, Mariana S, Vatner, Stephen F, Lewandowski, E. Douglas

“…Abstract Human studies indicate augmented myocardial lipid metabolism in females, and that sex and obesity interact to predict myocardial fatty acid oxidation…”
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Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption by De Lorenzo, Mariana S., Chen, Wen, Baljinnyam, Erdene, Carlini, María J., La Perle, Krista, Bishop, Sanford P., Wagner, Thomas E., Rabson, Arnold B., Vatner, Dorothy E., Puricelli, Lydia I., Vatner, Stephen F.

“…Summary Disruption of adenylyl cyclase type 5 (AC5) knockout (KO) is a novel model for longevity. Because malignancy is a major cause of death and reduced…”
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Role of Protein Kinase C-dependent Signaling Pathways in the Antiangiogenic Properties of Nafoxidine by DE LORENZO, Mariana S, FARINA, Hernan G, ALONSO, Daniel F, GOMEZ, Daniel E

“…We analyzed the effect of nafoxidine on the earlier biological processes of angiogenesis and explored the role of different signaling pathways involved in the…”
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Caloric restriction reduces growth of mammary tumors and metastases by DE LORENZO, Mariana S, BALJINNYAM, Erdene, VATNER, Dorothy E, ABARZUA, Patricio, VATNER, Stephen F, RABSON, Arnold B

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