Molecular mechanisms of early lung specification and branching morphogenesis

Molecular mechanisms of early lung specification and branching morphogenesis

The "hard wiring" encoded within the genome that determines the emergence of the laryngotracheal groove and subsequently early lung branching morphogenesis is mediated by finely regulated, interactive growth factor signaling mechanisms that determine the automaticity of branching, interbra...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric research Vol. 57; no. 5; pp. 26 - 37
Main Authors: WARBURTON, David, BELLUSCI, Saverio, DE LANGHE, Stun, DEL MORAL, Pierre-Marie, FLEURY, Vincent, MAILLEUX, Arnaud, TEFFT, Denise, UNBEKANDT, Mathieu, WANG, Kasper, WEI SHI
Format: Journal Article
Language:English
Published: Hagerstown, MD Lippincott Williams & Wilkins 01-05-2005
Subjects:
Animals
Biological and medical sciences
Cell Lineage
Drosophila
Epithelium - metabolism
Esophagus - pathology
Fibroblast Growth Factors - biosynthesis
Gene Expression Regulation, Developmental
General aspects
Hedgehog Proteins
Humans
Intercellular Signaling Peptides and Proteins - biosynthesis
Larynx - metabolism
Ligands
Lung - embryology
Lung - metabolism
Lung - pathology
Medical sciences
Models, Biological
Mutation
Neovascularization, Physiologic
Peptides - chemistry
Protein Isoforms
Signal Transduction
Trachea - metabolism
Trachea - pathology
Trans-Activators - biosynthesis
Transforming Growth Factor beta - biosynthesis
Vascular Endothelial Growth Factor A - biosynthesis
Wnt Proteins
Morphogenesis
Branching
Pediatrics
Lung
Early
Specification
Molecular biology
Respiratory system
Mechanism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The "hard wiring" encoded within the genome that determines the emergence of the laryngotracheal groove and subsequently early lung branching morphogenesis is mediated by finely regulated, interactive growth factor signaling mechanisms that determine the automaticity of branching, interbranch length, stereotypy of branching, left-right asymmetry, and finally gas diffusion surface area. The extracellular matrix is an important regulator as well as a target for growth factor signaling in lung branching morphogenesis and alveolarization. Coordination not only of epithelial but also endothelial branching morphogenesis determines bronchial branching and the eventual alveolar-capillary interface. Improved prospects for lung protection, repair, regeneration, and engineering will depend on more detailed understanding of these processes. Herein, we concisely review the functionally integrated morphogenetic signaling network comprising the critical bone morphogenetic protein, fibroblast growth factor, Sonic hedgehog, transforming growth factor-beta, vascular endothelial growth factor, and Wnt signaling pathways that specify and drive early embryonic lung morphogenesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0031-3998
1530-0447
DOI:10.1203/01.pdr.0000159570.01327.ed