Search Results - "DE KLOET, E. R"

Brain-Derived Neurotrophic Factor and Antidepressive Effect of Electroconvulsive Therapy: Systematic Review and Meta-Analyses of the Preclinical and Clinical Literature by Polyakova, M, Schroeter, M L, Elzinga, B M, Holiga, S, Schoenknecht, P, de Kloet, E R, Molendijk, M L

“…Emerging data suggest that Electro-Convulsive Treatment (ECT) may reduce depressive symptoms by increasing the expression of Brain-Derived Neurotrophic Factor…”
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Do Corticosteroids Damage the Brain? by Herbert, J., Goodyer, I. M., Grossman, A. B., Hastings, M. H., De Kloet, E. R., Lightman, S. L., Lupien, S. J., Roozendaal, B., Seckl, J. R.

“…Corticosteroids are an essential component of the body's homeostatic system. In common with other such systems, this implies that corticosteroid levels in…”
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Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour by Harris, A.P, Holmes, M.C, de Kloet, E.R, Chapman, K.E, Seckl, J.R

“…Summary An imbalance between central glucocorticoid (GR) and mineralocorticoid (MR) receptors is proposed to underlie the HPA axis dysregulation that…”
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Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism by de Kloet, E. R., Molendijk, M. L.

“…In the forced swim test (FST) rodents progressively show increased episodes of immobility if immersed in a beaker with water from where escape is not possible…”
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Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior by Fitzsimons, C P, van Hooijdonk, L W A, Schouten, M, Zalachoras, I, Brinks, V, Zheng, T, Schouten, T G, Saaltink, D J, Dijkmans, T, Steindler, D A, Verhaagen, J, Verbeek, F J, Lucassen, P J, de Kloet, E R, Meijer, O C, Karst, H, Joels, M, Oitzl, M S, Vreugdenhil, E

“…Glucocorticoids (GCs) secreted after stress reduce adult hippocampal neurogenesis, a process that has been implicated in cognitive aspects of psychopathology,…”
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Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors by Olijslagers, J. E., De Kloet, E. R., Elgersma, Y., Van Woerden, G. M., Joëls, M., Karst, H.

“…Corticosterone (100 nm) rapidly increases the frequency of miniature excitatory postsynaptic currents in mouse CA1 pyramidal neurons via membrane‐located…”
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Nuclear Receptor Coregulators Differentially Modulate Induction and Glucocorticoid Receptor-Mediated Repression of the Corticotropin-Releasing Hormone Gene by van der Laan, S, Lachize, S. B, Vreugdenhil, E, de Kloet, E. R, Meijer, O. C

“…Nuclear receptor coregulators are proteins that modulate the transcriptional activity of steroid receptors and may explain cell-specific effects of…”
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Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor by de Kloet, E. R., Otte, C., Kumsta, R., Kok, L., Hillegers, M. H. J., Hasselmann, H., Kliegel, D., Joëls, M.

“…Cortisol and corticosterone act on the appraisal process, which comprises the selection of an appropriate coping style and the encoding of the experience for…”
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Hypothalamic-Pituitary-Adrenal Axis Activity of Newborn Mice Rapidly Desensitizes to Repeated Maternal Absence but Becomes Highly Responsive to Novelty by Enthoven, L, Oitzl, M. S, Koning, N, van der Mark, M, de Kloet, E. R

“…In CD1 mice we investigated the hypothalamic-pituitary-adrenal (HPA) axis response to maternal separation for 8 h daily from postnatal d 3 to 5. At d 3 a slow…”
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Steroid Receptor Coactivator-1 Splice Variants Differentially Affect Corticosteroid Receptor Signaling by Meijer, O. C, Kalkhoven, E, van der Laan, S, Steenbergen, P. J, Houtman, S. H, Dijkmans, T. F, Pearce, D, de Kloet, E. R

“…The mechanisms of receptor- and cell-specific effects of the adrenal corticosteroid hormones via mineralo- (MRs) and glucocorticoid receptors (GRs) are still…”
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Relevance of Stress and Female Sex Hormones for Emotion and Cognition by ter Horst, J. P., de Kloet, E. R., Schächinger, H., Oitzl, M. S.

“…There are clear sex differences in incidence and onset of stress-related and other psychiatric disorders in humans. Yet, rodent models for psychiatric…”
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Glucocorticoid signaling and stress-related limbic susceptibility pathway: About receptors, transcription machinery and microRNA by de Kloet, E.R, Fitzsimons, C.P, Datson, N.A, Meijer, O.C, Vreugdenhil, E

“…Abstract Background. Stress is essential for health, but if coping with stress fails, the action of the stress hormones cortisol and corticosterone (CORT)…”
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Glucocorticoid pulsatility and rapid corticosteroid actions in the central stress response by Sarabdjitsingh, R.A, Joëls, M, de Kloet, E.R

“…Abstract Glucocorticoid hormones are secreted from the adrenal gland in hourly pulses, on top of which a surge can take place after stress. The current review…”
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Low Doses of Dexamethasone Can Produce a Hypocorticosteroid State in the Brain by Karssen, A. M, Meijer, O. C, Berry, A, Sanjuan Piñol, R, de Kloet, E. R

“…The synthetic glucocorticoid dexamethasone (dex) blocks stress-induced hypothalamic-pituitary-adrenal (HPA) activation primarily at the level of the anterior…”
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Acute Activation of Hippocampal Glucocorticoid Receptors Results in Different Waves of Gene Expression Throughout Time by Morsink, M. C., Steenbergen, P. J., Vos, J. B., Karst, H., Joëls, M., De Kloet, E. R., Datson, N. A.

“…Several aspects of hippocampal cell function are influenced by adrenal‐secreted glucocorticoids in a delayed, genomic fashion. Previously, we used Serial…”
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A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis by R H Derijk, M J Schaaf, G Turner, N A Datson, E Vreugdenhil, J Cidlowski, E R de Kloet, P Emery, E M Sternberg, S D Detera-Wadleigh

“…OBJECTIVE: To study the occurrence and function of polymorphism in the human glucocorticoid receptor (hGR) gene in rheumatoid arthritis (RA) and systemic lupus…”
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Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers by Joëls, M, Karst, H, Karten, Y. J. G, Reichardt, H. M, de Kloet, E. R, Schütz, G

“…Glucocorticoids are secreted from the adrenal gland in very high amounts after stress. In the brain, these stress hormones potently modulate ionic currents,…”
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Glucocorticoid Receptor Blockade Disinhibits Pituitary-Adrenal Activity during the Stress Hyporesponsive Period of the Mouse by Schmidt, M, Levine, S, Oitzl, M. S, van der Mark, M, Müller, M. B, Holsboer, F, de Kloet, E. R

“…During postnatal development, mice undergo a period of reduced responsiveness of the pituitary-adrenal axis, the stress hyporesponsive period (SHRP), which is…”
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About Stress Hormones and Resilience to Psychopathology by De Kloet, E. R.

“…Neuroendocrinology links experience and behaviour to the action of hormones. This review focusses on the corticosteroids, released in hourly pulses and after…”
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Stress or no stress: Mineralocorticoid receptors in the forebrain regulate behavioral adaptation by ter Horst, J.P., van der Mark, M.H., Arp, M., Berger, S., de Kloet, E.R., Oitzl, M.S.

“…► This study demonstrates the relevance of MR for adaptive behavior. ► MR forebrain deficient mice (MRCaMKCre) need more time to learn a spatial task. ► Stress…”
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