Search Results - "DE JONGE, Robert"

A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells by Polman, J Annelies E, Welten, Jennifer E, Bosch, Danny S, de Jonge, Robert T, Balog, Judit, van der Maarel, Silvère M, de Kloet, E Ronald, Datson, Nicole A

“…Glucocorticoids, secreted by the adrenals in response to stress, profoundly affect structure and plasticity of neurons. Glucocorticoid action in neurons is…”
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Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages by Muller, Ittai B, Lin, Marry, Jonge, Robert de, Will, Nico, López-Navarro, Baltasar, Laken, Conny van der, Struys, Eduard A, Oudejans, Cees B M, Assaraf, Yehuda G, Cloos, Jacqueline, Puig-Kröger, Amaya, Jansen, Gerrit

“…Macrophages constitute important immune cell targets of the antifolate methotrexate (MTX) in autoimmune diseases, including rheumatoid arthritis. Regulation of…”
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A higher incidence of chondral injuries on the medial femoral condyle in concomitant ACL ruptures, no significant difference in treatment: A systematic review by Hanlon, Jack, Máté, Miklós, de Jonge, Róbert, Bäcker, Henrik C, Panics, Gergely

“…The associated damage to articular cartilage in anterior cruciate ligament (ACL) injured patients is a well-recognized phenomenon; however, there is a relative…”
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Design of fork-join networks of First-In-First-Out and infinite-server queues applied to clinical chemistry laboratories by Tsai, Eline R., Demirtas, Derya, Tintu, Andrei N., de Jonge, Robert, de Rijke, Yolanda B., Boucherie, Richard J.

“…•Accurate queueing network capturing performance of real-world laboratory systems.•Centralized decision maker that optimizes static routes minimizing mean…”
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Computational comparison of common event-based differential splicing tools: practical considerations for laboratory researchers by Muller, Ittai B, Meijers, Stijn, Kampstra, Peter, van Dijk, Steven, van Elswijk, Michel, Lin, Marry, Wojtuszkiewicz, Anna M, Jansen, Gerrit, de Jonge, Robert, Cloos, Jacqueline

“…Abstract Background Computational tools analyzing RNA-sequencing data have boosted alternative splicing research by identifying and assessing differentially…”
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Validation of the body fluid module on the new Sysmex XN-1000 for counting blood cells in cerebrospinal fluid and other body fluids by Fleming, Chérina, Brouwer, Rob, Lindemans, Jan, de Jonge, Robert

“…We evaluated the body fluid (BF) module on the new Sysmex XN-1000 for counting blood cells. One hundred and eighty-seven BF samples [73 cerebrospinal fluid…”
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Development and validation of a prognostic multivariable model to predict insufficient clinical response to methotrexate in rheumatoid arthritis by de Rotte, Maurits C F J, Pluijm, Saskia M F, de Jong, Pascal H P, Bulatović Ćalasan, Maja, Wulffraat, Nico M, Weel, Angelique E A M, Lindemans, Jan, Hazes, J M W, de Jonge, Robert

“…The objective was to predict insufficient response to 3 months methotrexate (MTX) in DMARD naïve rheumatoid arthritis patients. A Multivariable logistic…”
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Faecal Volatile Organic Compound Analysis in De Novo Paediatric Inflammatory Bowel Disease by Gas Chromatography-Ion Mobility Spectrometry: A Case-Control Study by Vermeer, Eva, Jagt, Jasmijn Z, Stewart, Trenton K, Covington, James A, Struys, Eduard A, de Jonge, Robert, de Boer, Nanne K H, de Meij, Tim G J

“…The gut microbiota and its related metabolites differ between inflammatory bowel disease (IBD) patients and healthy controls. In this study, we compared faecal…”
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Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients by Gosselt, Helen R, Vallerga, Costanza L, Mandaviya, Pooja R, Lubberts, Erik, Hazes, Johanna M W, de Jonge, Robert, Heil, Sandra G

“…To identify differentially methylated positions (DMPs) and regions (DMRs) that predict response to Methotrexate (MTX) in early rheumatoid arthritis (RA)…”
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The When, What & How of Measuring Vitamin D Metabolism in Clinical Medicine by Dirks, Niek F, Ackermans, Mariëtte T, Lips, Paul, de Jongh, Renate T, Vervloet, Marc G, de Jonge, Robert, Heijboer, Annemieke C

“…We now have the ability to measure a number of different vitamin D metabolites with very accurate methods. The most abundant vitamin D metabolite,…”
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Global DNA (hydroxy)methylation is stable over time under several storage conditions and temperatures by Gosselt, Helen R., Griffioen, Pieter H., van Zelst, Bertrand D., Oosterom, Natanja, de Jonge, Robert, Heil, Sandra G.

“…Background: Epigenetic markers are often quantified and related to disease in stored samples. While, effects of storage on stability of these markers have not…”
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Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients by Gosselt, Helen R, van Zelst, Bertrand D, de Rotte, Maurits C F J, Hazes, Johanna M W, de Jonge, Robert, Heil, Sandra G

“…Low-dose methotrexate (MTX) is the first-line therapy in early rheumatoid arthritis (eRA). Up to 40% of eRA patients do not benefit from MTX therapy. MTX has…”
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Effect of antiretroviral therapy on bone turnover and bone mineral density in men with primary HIV-1 infection by Vlot, Mariska C, Grijsen, Marlous L, Prins, Jan M, de Jongh, Renate T, de Jonge, Robert, den Heijer, Martin, Heijboer, Annemieke C

“…Previous studies indicate that human immunodeficiency virus (HIV)-infection and combination antiretroviral therapy (cART) can affect bone turnover…”
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Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia by Oosterom, Natanja, de Jonge, Robert, Smith, Desiree E C, Pieters, Rob, Tissing, Wim J E, Fiocco, Marta, van Zelst, Bertrand D, van den Heuvel-Eibrink, Marry M, Heil, Sandra G

“…Methotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment. Folinic acid rescue therapy (Leucovorin) is…”
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Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia by Oosterom, Natanja, Griffioen, Pieter H, den Hoed, Marissa A H, Pieters, Rob, de Jonge, Robert, Tissing, Wim J E, van den Heuvel-Eibrink, Marry M, Heil, Sandra G

“…Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that…”
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Second-tier Testing for 21-Hydroxylase Deficiency in the Netherlands: A Newborn Screening Pilot Study by Stroek, Kevin, Ruiter, An, van der Linde, Annelieke, Ackermans, Mariette, Bouva, Marelle J, Engel, Henk, Jakobs, Bernadette, Kemper, Evelien A, van den Akker, Erica L T, van Albada, Mirjam E, Bocca, Gianni, Finken, Martijn J J, Hannema, Sabine E, Mieke Houdijk, E C A, van der Kamp, Hetty J, van Tellingen, Vera, Paul van Trotsenburg, A S, Zwaveling-Soonawala, Nitash, Bosch, Annet M, de Jonge, Robert, Heijboer, Annemieke C, Claahsen-van der Grinten, Hedi L, Boelen, Anita

“…Abstract Context Newborn screening (NBS) for classic congenital adrenal hyperplasia (CAH) consists of 17-hydroxyprogesterone (17-OHP) measurement with…”
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Diagnostic stewardship for blood cultures in the emergency department: A multicenter validation and prospective evaluation of a machine learning prediction tool by Schinkel, Michiel, Boerman, Anneroos W., Bennis, Frank C., Minderhoud, Tanca C., Lie, Mei, Peters-Sengers, Hessel, Holleman, Frits, Schade, Rogier P., de Jonge, Robert, Wiersinga, W. Joost, Nanayakkara, Prabath W.B.

“…Overuse of blood cultures (BCs) in emergency departments (EDs) leads to low yields and high numbers of contaminated cultures, accompanied by increased…”
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Appropriate use of blood cultures in the emergency department through machine learning (ABC): study protocol for a randomised controlled non-inferiority trial by van der Zaag, Anuschka Y, Bhagirath, Sheena C, Boerman, Anneroos W, Schinkel, Michiel, Paranjape, Ketan, Azijli, Kaoutar, Ridderikhof, Milan L, Lie, Mei, Lissenberg-Witte, Birgit, Schade, Rogier, Wiersinga, Joost, de Jonge, Robert, Nanayakkara, Prabath W B

“…IntroductionThe liberal use of blood cultures in emergency departments (EDs) leads to low yields and high numbers of false-positive results. False-positive,…”
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Micronutrient Status of Critically Ill Patients with COVID-19 Pneumonia by Rozemeijer, Sander, Hamer, Henrike M, Heijboer, Annemieke C, de Jonge, Robert, Jimenez, Connie R, Juffermans, Nicole P, Dujardin, Romein W G, Girbes, Armand R J, de Man, Angélique M E

“…Micronutrient deficiencies can develop in critically ill patients, arising from factors such as decreased intake, increased losses, drug interactions, and…”
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Critical evaluation of the newborn screening for congenital hypothyroidism in the Netherlands by Stroek, Kevin, Heijboer, Annemieke C, Bouva, Marelle J, van der Ploeg, Catharina P B, Heijnen, Marie-Louise A, Weijman, Gert, Bosch, Annet M, de Jonge, Robert, Schielen, Peter C J I, van Trotsenburg, A S Paul, Boelen, Anita

“…Objective: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency at birth due to disorders of the thyroid gland (thyroidal CH, CH-T), or the…”
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