Search Results - "DE JONG, Joan H"

Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry by Trinh, Anne, Trumpi, Kari, De Sousa E Melo, Felipe, Wang, Xin, de Jong, Joan H, Fessler, Evelyn, Kuppen, Peter J K, Reimers, Marlies S, Swets, Marloes, Koopman, Miriam, Nagtegaal, Iris D, Jansen, Marnix, Hooijer, Gerrit K J, Offerhaus, George J A, Kranenburg, Onno, Punt, Cornelis J, Medema, Jan Paul, Markowetz, Florian, Vermeulen, Louis

“…Recent transcriptomic analyses have identified four distinct molecular subtypes of colorectal cancer with evident clinical relevance. However, the requirement…”
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Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients by de Sousa E Melo, Felipe, Colak, Selcuk, Buikhuisen, Joyce, Koster, Jan, Cameron, Kate, de Jong, Joan H., Tuynman, Jurriaan B., Prasetyanti, Pramudita R., Fessler, Evelyn, van den Bergh, Saskia P., Rodermond, Hans, Dekker, Evelien, van der Loos, Chris M., Pals, Steven T., van de Vijver, Marc J., Versteeg, Rogier, Richel, Dick J., Vermeulen, Louis, Medema, Jan Paul

“…Gene signatures derived from cancer stem cells (CSCs) predict tumor recurrence for many forms of cancer. Here, we derived a gene signature for colorectal CSCs…”
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Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions by De Sousa E Melo, Felipe, Wang, Xin, Jansen, Marnix, Fessler, Evelyn, Trinh, Anne, de Rooij, Laura P M H, de Jong, Joan H, de Boer, Onno J, van Leersum, Ronald, Bijlsma, Maarten F, Rodermond, Hans, van der Heijden, Maartje, van Noesel, Carel J M, Tuynman, Jurriaan B, Dekker, Evelien, Markowetz, Florian, Medema, Jan Paul, Vermeulen, Louis

“…Analysis of gene-expression profiles led to the identification of three molecularly distinct subtypes of colon cancer. One of these subtypes is new, and its…”
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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment by Merz, Christian, Medema, Jan Paul, Rodermond, Hans, Borovski, Tijana, Sprick, Martin R, Richel, Dick J, de Jong, Joan H, Todaro, Matilde, Cameron, Kate, De Sousa E Melo, Felipe, van der Heijden, Maartje, Vermeulen, Louis, Tuynman, Jurriaan B, Kemper, Kristel, Stassi, Giorgio

“…Cancer stem cell activity may not merely be an intrinsic characteristic of a subset of cancer cells and could be regulated by environmental cues. High Wnt…”
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High‐grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF‐1 by Steins, Anne, van Mackelenbergh, Madelaine G, van der Zalm, Amber P, Klaassen, Remy, Serrels, Bryan, Goris, Sandrine G, Kocher, Hemant M, Waasdorp, Cynthia, de Jong, Joan H, Tekin, Cansu, Besselink, Marc G, Busch, Olivier R, van de Vijver, Marc J, Verheij, Joanne, Dijk, Frederike, van Tienhoven, Geertjan, Wilmink, Johanna W, Medema, Jan Paul, van Laarhoven, Hanneke WM, Bijlsma, Maarten F

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundance of stroma. Multiple molecular classification efforts have identified a mesenchymal…”
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Mutations in the Ras-Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer by KEMPER, Kristel, VERSLOOT, Miranda, MEDEMA, Jan Paul, CAMERON, Katherine, COLAK, Selçuk, DE SOUSA E MELO, Felipe, DE JONG, Joan H, BLEACKLEY, Joanne, VERMEULEN, Louis, VERSTEEG, Rogier, KOSTER, Jan

“…High expression of cancer stem cell (CSC) marker CD133 has been used as a predictor for prognosis in colorectal cancer (CRC), suggesting that enumeration of…”
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Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer by Buikhuisen, Joyce Y, Gomez Barila, Patricia M, Cameron, Kate, Suijkerbuijk, Saskia J E, Lieftink, Cor, di Franco, Simone, Krotenberg Garcia, Ana, Uceda Castro, Rebeca, Lenos, Kristiaan J, Nijman, Lisanne E, Torang, Arezo, Longobardi, Ciro, de Jong, Joan H, Dekker, Daniëlle, Stassi, Giorgio, Vermeulen, Louis, Beijersbergen, Roderick L, van Rheenen, Jacco, Huveneers, Stephan, Medema, Jan Paul

“…Colorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is associated with…”
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Capturing colorectal cancer inter‐tumor heterogeneity in patient‐derived xenograft (PDX) models by Prasetyanti, Pramudita R., Hooff, Sander R., Herwaarden, Tessa, Vries, Nathalie, Kalloe, Kieshen, Rodermond, Hans, Leersum, Ronald, Jong, Joan H., Franitza, Marek, Nürnberg, Peter, Todaro, Matilde, Stassi, Giorgio, Medema, Jan Paul

“…Patient‐derived xenograft (PDX) models have become an important asset in translational cancer research. However, to provide a robust preclinical platform, PDXs…”
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AKT3 Expression in Mesenchymal Colorectal Cancer Cells Drives Growth and Is Associated with Epithelial-Mesenchymal Transition by Buikhuisen, Joyce Y, Gomez Barila, Patricia M, Torang, Arezo, Dekker, Daniëlle, de Jong, Joan H, Cameron, Kate, Vitale, Sara, Stassi, Giorgio, van Hooff, Sander R, Castro, Mauro A A, Vermeulen, Louis, Medema, Jan Paul

“…Colorectal cancer (CRC) is a heterogeneous disease that can currently be subdivided into four distinct consensus molecular subtypes (CMS) based on gene…”
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Abstract 3193: Development of a colon cancer model system reveals epithelial contribution to poor-prognosis gene signatures by Prasetyanti, Pramudita R., van Hooff, Sander R., Rodermond, Hans M., van Herwaarden, Tessa, Kalloe, Kieshen, de Vries, Nathalie R., van Leersum, Ronals, de jong, Joan H., Fessler, Evelyn, Baldi, Nicolo, Stassi, Giorgio, Medema, Jan Paul

“…Abstract Background: Recent consensus on molecular classification categorizes colorectal cancer (CRC) into 4 robust subtypes: CMS1 (epithelial-MSI), CMS2…”
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Pre-Operative Decitabine in Colon Cancer Patients: Analyses on WNT Target Methylation and Expression by Linnekamp, Janneke F., Kandimalla, Raju, Fessler, Evelyn, de Jong, Joan H., Rodermond, Hans M., van Bochove, Gregor G. W., The, Frans O., Punt, Cornelis J. A., Bemelman, Willem A., van de Ven, Anthony W. H., Tanis, Pieter J., Kemper, Elles M., Koens, Lianne, Dekker, Evelien, Vermeulen, Louis, van Laarhoven, Hanneke W. M., Medema, Jan Paul

“…DNA hypermethylation is common in colon cancer. Previously, we have shown that methylation of WNT target genes predicts poor prognosis in stage II colon…”
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Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis by de Jong, Joan H., Rodermond, Hans M., Zimberlin, Cheryl D., Lascano, Valeria, De Sousa E Melo, Felipe, Richel, Dick J., Medema, Jan Paul, Vermeulen, Louis

“…The epithelial lining of the intestine is characterized by an immense cellular turn-over ascertaining an extensive regenerative capacity. Multiple reports…”
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Abstract LB-108: Automated immunohistochemistry-based identification of molecular subtypes in colorectal cancer by Trinh, Anne, De Sousa E Melo, Filipe, Wang, Xin, de Jong, Joan H, Fessler, Evelyn, Jansen, Marnix, Hooijer, Gerrit KJ, Medema, Jan Paul, Markowetz, Florian, Vermeulen, Louis

“…Abstract BACKGROUND Recent molecular profiling of colorectal cancer has identified three distinct subtypes: two good-prognosis subtypes characterised by…”
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Durable Remission of Renal Cell Carcinoma After Donor Lymphocyte Infusion Is Unavoidably Linked with Graft Versus Host Disease As Illustrated by the Detection of Allo Reactive T Cells Recognizing a Novel Minor Histocompatibility Antigen Encoded by the FUCA2 Gene by van Bergen, Cornelis A.M., Verdegaal, Elizabeth M.E., Hoogstraten, Conny, van Steijn, A.Q.M. Jeanne, de Quartel, Linda, de Jong, Joan H., Meyering, Maaike, Griffioen, Marieke, Falkenburg, J.H.Frederik, Osanto, Susanne

“…Abstract 4467 Allogeneic stem cell transplantation (allo SCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to…”
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Immunotherapy of cancer by peptide-based vaccines for the induction of tumor-specific T cell immunity by Ressing, Maaike E, Offringa, Rienk, Toes, RenéE.M, Ossendorp, Ferry, de Jong, Joan H, Brandt, Remco M.P, Kast, W.Martin, Melief, Cornelis J.M

“…Recent progress in defining the molecular nature of antigens and in finding ways to manipulate T cell-mediated immune responses may provide new modalities for…”
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Detection of T helper responses, but not of Human papillomavirus-specific cytotoxic T lymphocyte responses, after peptide vaccination of patients with cervical carcinoma by RESSING, M. E, VAN DRIEL, W. J, CELIS, E, GREY, H, TRIMBOS, B. J, KAST, W. M, MELIEF, C. J. M, BRANDT, R. M. P, KENTER, T. G, DE JONG, J. H, BAUKNECHT, T, FLEUREN, G.-J, HOOGERHOUT, P, OFFRINGA, R, SETTE, A

“…Human papillomavirus type 16 (HPV16)-encoded E7 oncoprotein is constitutively expressed in cervical carcinoma cells and is required for cellular transformation…”
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Differential binding of viral peptides to HLA‐A2 alleles. Implications for human papillomavirus type 16 E7 peptide‐based vaccination against cervical carcinoma by Ressing, Maaike E., de Jong, Joan H., Brandt, Remco M. P., Drijfhout, Jan Wouter, Benckhuijsen, Willemien E., Schreuder, Geziena M. T., Offringa, Rienk, Kast, W. Martin, Melief, Cornelis J. M.

“…Several cancer immune intervention protocols aim at inducing T cell immunity against antigens presented by HLA‐A2, the most common human MHC class I molecule…”
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