Search Results - "DE GAST, Gijsbert"

Immunogenicity, Including Vitiligo, and Feasibility of Vaccination With Autologous GM-CSF–Transduced Tumor Cells in Metastatic Melanoma Patients by LUITEN, Rosalie M, KUETER, Esther W. M, SEIN, Johan, VAN DEN BERK, Paul C. M, NIEWEG, Omgo E, BERNS, Anton M, SPITS, Hereen, DE GAST, Giisbert C, MOOI, Walter, GALLEE, Maarten P. W, RANKIN, Elaine M, GERRITSEN, Winald R, CLIFT, Shirley M, NOOIJEN, Willem J, WEDER, Pauline, VAN DE KASTEELE, Willeke F

“…To determine the feasibility, toxicity, and immunologic effects of vaccination with autologous tumor cells retrovirally transduced with the GM-CSF gene, we…”
Get full text

Sunitinib for Treatment of Advanced Renal Cell Cancer: Primary Tumor Response by VAN DER VELDT, Astrid A. M, MEIJERINK, Martijn R, VAN DEN EERTWEGH, Alfons J. M, BEX, Axel, DE GAST, Gijsbert, HAANEN, John B. A. G, BOVEN, Epie

“…Purpose: Nephrectomy before immunotherapy in patients with metastatic renal cell cancer (RCC) will improve patient outcome. In addition, the primary tumor is…”
Get full text

Long-term persistence of T cell memory to HBsAg after hepatitis B vaccination by Wang, Ru-Xiang, Boland, Greet J, van Hattum, Jan, de Gast, Gijsbert C

“…AIM:To determine if the T cell memory to HBsAg can persist for a long time after hepatitis B (HB) vaccination.METHODS: Thirty one vaccine recipients who…”
Get full text

A phase-II study of pegylated interferon alfa-2b for patients with metastatic renal cell carcinoma and removal of the primary tumor by BEX, Axel, MALLO, Henk, KERST, Martijn, HAANEN, John, HORENBLAS, Simon, DE GAST, Gijsbert C

“…Twenty-two patients with metastatic renal cell carcinoma and removal of the primary tumor were treated with subcutaneous pegylated interferon alfa-2b…”
Get full text

Radio frequency ablation combined with interleukin-2 induces an antitumor immune response to renal cell carcinoma in a murine model by Kroeze, Stephanie G C, Daenen, Laura G M, Nijkamp, Maarten W, Roodhart, Jeanine M L, de Gast, Gijsbert C, Bosch, J L H Ruud, Jans, Judith J M

“…Immune based therapy has gained renewed interest in the search for treatment strategies for metastasized renal cell carcinoma. We determined whether radio…”
Get more information

The Timing of Immunotherapy and Nephrectomy in Multimodality Treatment of Metastatic Renal Cell Carcinoma by Bex, Axel, Horenblas, Simon, de Gast, Gijsbert C.

“…Multimodality treatment of metastatic renal cell carcinoma with immunotherapy and cytoreductive surgery is controversial. Especially the benefit of removing…”
Get full text

Temozolomide in advanced malignant melanoma with small brain metastases : Can we withhold cranial irradiation? by BOOGERD, Willem, DE GAST, Gijsbert C, DALESIO, Otilia

“…The efficacy of radiotherapy (RT) in patients who have brain metastases from melanoma is limited. In this study, the authors evaluated the efficacy of…”
Get full text

On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients by VAN OIJEN, Monique, BINS, Adriaan, HAANEN, John, ELIAS, Sjoerd, SEIN, Johan, WEDER, Pauline, DE GAST, Gijsbert, MALLO, Henk, GALLEE, Maarten, VAN TINTEREN, Harm, SCHUMACHER, Ton

“…Cytotoxic T-cell immunity directed against melanosomal differentiation antigens is arguably the best-studied and most prevalent form of tumor-specific T-cell…”
Get full text

Comparison of CHOP Chemotherapy with Autologous Bone Marrow Transplantation for Slowly Responding Patients with Aggressive Non-Hodgkin's Lymphoma by Verdonck, Leo F, van Putten, Wim L.J, Hagenbeek, Anton, Schouten, Harry C, Sonneveld, Pieter, van Imhoff, Gustaaf W, Kluin-Nelemans, Hanneke C, Raemaekers, John M.M, van Oers, Rien H.J, Haak, Hans L, Schots, Rik, Dekker, Adriaan W, de Gast, Gijsbert C, Löwenberg, Bob

“…Combination chemotherapy can cure about 45 percent of patients with disseminated intermediate-grade or high-grade non-Hodgkin's lymphoma. 1 Several…”
Get full text

Cytokine therapy response as a selection criterion for cytoreductive nephrectomy in metastatic renal clear-cell carcinoma of intermediate prognosis. Results and conclusions from a combined analysis by Bex, Axel, Haanen, John B A G, Vyth-Dreese, Florry A, Horenblas, Simon, de Gast, Gijsbert C

“…To assess the strategy of using an absence of progression at metastatic sites following initial cytokine therapy outcome as a selection criterion for…”
Get more information

Lack of elevation of serum S100B in patients with metastatic melanoma as a predictor of outcome after induction with an autologous vaccine of proliferating tumor cells and dendritic cells by Schiltz, Patric M, Dillman, Robert O, Korse, Catharina M, Cubellis, James M, Lee, Gregory J, De Gast, Gijsbert C

“…Serum levels of S100B and/or lactate dehydrogenase (LDH) are putative tumor markers in melanoma. Early changes in such markers may correlate with a positive…”
Get more information

Phase I/II study of sequential chemoimmunotherapy (SCIT) for metastatic melanoma: outpatient treatment with dacarbazine, granulocyte-macrophage colony-stimulating factor, low-dose interleukin-2, and interferon-alpha by GROENEWEGEN, Gerard, BLOEM, Andries, DE GAST, Gijsbert C

“…A regimen of sequential chemoimmunotherapy (SCIT) was studied in a phase I/II study to analyze toxicity, anti-tumor and immunomodulatory effects in patients…”
Get full text

Normal values of serum S-100B predict prolonged survival for stage IV melanoma patients by Smit, Léonie H.M., Korse, Catharina M., Hart, Augustinus A.M., Bonfrer, Johannes M.G., Haanen, John B.A.G., Kerst, J. Martijn, Nieweg, Omgo E., de Gast, Gijsbert C.

“…The value of normal S-100B levels to predict survival was evaluated in 145 patients with stage IV melanoma. Treatment consisted of temozolomide given alone or…”
Get full text

Preclinical evaluation of anti-CD86 immunotoxin in rhesus monkeys: analysis of systemic toxicity, pharmacokinetics, and effect on primary T-cell responses by OTTEN, Henderikus G, DE GAST, Gijsbert C, VOOIJS, Wim C, VAN DER GOUW, Alexander P, DE BOER, Mark, OSSEVOORT, Mirjam A, JONKER, Margreet

“…CD86 and CD80 costimulatory antigens are highly overexpressed on Hodgkin/Reed-Sternberg cells in patients with Hodgkin's disease (HD) and are candidate target…”
Get full text

Is a low dose of hepatitis B vaccine enough for a rapid vaccination scheme? by Wang, Ru-Xiang, Boland, Greet, Guo, Ying, Lei, Shao-Ping, Yang, Chang-Hong, Chen, Juan, Tian, Jie, Wen, Jin-Ying, Du, Ke-Hong, van Hattum, Jan, de Gast, Gijsbert C

“…To determine whether or not a low dose of HB vaccine can be effectively used in the rapid vaccination. Rapid vaccination (0, 1, 2 months) with low dose (5…”
Get full text

Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A0201-positive melanoma patients by BINS, Adriaan, MALLO, Henk, SEIN, Johan, VAN DEN BOGAARD, Colette, NOOIJEN, Willem, VYTH-DREESE, Florry, NUIJEN, Bastiaan, DE GAST, Gijsbert C, HAANEN, John B. A. G

“…Successful induction of functional tumor-specific T cells by peptide vaccination in animal models has resulted in many clinical trials to test this approach in…”
Get full text

Phase I Trial of Combined Immunotherapy with Subcutaneous Granulocyte Macrophage Colony-stimulating Factor, Low-Dose Interleukin 2, and Interferon α in Progressive Metastatic Melanoma and Renal Cell Carcinoma by de Gast, G C, Klümpen, H J, Vyth-Dreese, F A, Kersten, M J, Verra, N C, Sein, J, Batchelor, D, Nooijen, W J, Schornagel, J H

“…The purpose of our study was to determine the maximally tolerated dose (MTD) and DLT of combined administration of granulocyte macrophage colony-stimulating…”
Get full text

Primary human keratinocytes as targets in predicting acute graft‐versus‐host disease following HLA‐identical bone marrow transplantation by van Dijk, Astrid M. C., Kessler, Floortje L., Verdonck, Leo F., Stadhouders‐Keet, Simone A. E., van Lier, Rene A. W., de Gast, Gijsbert C., Otten, Henny G.

“…Graft‐versus‐host‐disease (GVHD) remains a major problem following allogeneic bone marrow transplantation (BMT) and manifests itself mainly by damage to…”
Get full text

Determination of helper T‐cell precursor frequencies against non‐haemopoietic cells: comparison of co‐stimulation provided by anti‐CD28 antibody versus the cellular ligand B7‐1 by Van Dijk, Astrid M. C., De Gast, Gijsbert C., Kessler, Floortje L., Stadhouders‐Keet, Simone A. E., Van Lier, Rene A. W., Verdonck, Leo F., Otten, Henny G.

“…Helper T‐cell precursor frequency assays (HTLp‐assays) are commonly used in transplantation to examine the frequency of T cells reactive against donor or host…”
Get full text

Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells by van Lochem, Ellen, van der Keur, Maarten, Mommaas, A Mieke, de Gast, Gijsbert C, Goulmy, Els

“…Adequate presentation and cell surface expression of foreign minor histocompatibility antigens (mHag) to allogeneic T cells can lead to graft-versus-host…”
Get full text