Profile of Trypanosoma cruzi Reactivity in a Population at High Risk for Endemic Pemphigus Foliaceus (Fogo Selvagem)

Fogo selvagem (FS) is an autoimmune bullous disease with pathogenic IgG autoantibodies recognizing desmoglein 1 (Dsg1), a desmosomal glycoprotein. In certain settlements of Brazil, a high prevalence of FS (3%) is reported, suggesting environmental factors as triggers of the autoimmune response. Heal...

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Bibliographic Details
Published in:	The American journal of tropical medicine and hygiene Vol. 87; no. 4; pp. 675 - 680
Main Authors:	SOUSA, Joaquim X, DIAZ, Luis A, UMEZAWA, Eufrosina S, RIVITTI, Evandro A, AOKI, Valeria, EATON, Donald P, HANS-FILHO, Günter, DE FREITAS, Elder Lanzani, DELGADO, Livia, ICHIMURA, Ligia Maria F, CRISTALDI, Flávia, ORLANDI, Renata, KESPER, Norival
Format:	Journal Article
Language:	English
Published:	Deerfield, IL American Society of Tropical Medecine and Hygiene 01-10-2012 The American Society of Tropical Medicine and Hygiene
Subjects:	Adolescent Adult Aged Antibodies, Protozoan - blood Autoantibodies - blood Autoantibodies - immunology Biological and medical sciences Brazil - epidemiology Bullous diseases of the skin Chagas Disease - diagnosis Chagas Disease - epidemiology Chagas Disease - ethnology Chagas Disease - immunology Child Dermatology Desmoglein 1 - immunology Endemic Diseases Enzyme-Linked Immunosorbent Assay Female Humans Indians, South American Infectious diseases Male Medical sciences Middle Aged Pemphigus - epidemiology Pemphigus - ethnology Pemphigus - immunology Risk Factors Trypanosoma cruzi Trypanosoma cruzi - immunology Young Adult Brazil Bullous dermatosis Kinetoplastida Immunopathology Protozoa Skin disease Pemphigus foliaceous Autoimmune disease Tropical medicine Trypanosoma cruzi
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Summary:	Fogo selvagem (FS) is an autoimmune bullous disease with pathogenic IgG autoantibodies recognizing desmoglein 1 (Dsg1), a desmosomal glycoprotein. In certain settlements of Brazil, a high prevalence of FS (3%) is reported, suggesting environmental factors as triggers of the autoimmune response. Healthy individuals from endemic areas recognize nonpathogenic epitopes of Dsg1, and exposure to hematophagous insects is a risk factor for FS. Fogo selvagem and Chagas disease share some geographic sites, and anti-Dsg1 has been detected in Chagas patients. Indeterminate Chagas disease was identified in a Brazilian Amerindian population of high risk for FS. In counterpart, none of the FS patients living in the same geographic region showed reactivity against Trypanosoma cruzi. The profile of anti-Dsg1 antibodies showed positive results in 15 of 40 FS sera and in 33 of 150 sera from healthy individuals from endemic FS sites, and no cross-reactivity between Chagas disease and FS was observed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9637 1476-1645
DOI:	10.4269/ajtmh.2012.12-0206