Search Results - "DE FALCO, Valentina"

Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology by Frett, Brendan, Carlomagno, Francesca, Moccia, Maria Luisa, Brescia, Annalisa, Federico, Giorgia, De Falco, Valentina, Admire, Brittany, Chen, Zhongzhu, Qi, Wenqing, Santoro, Massimo, Li, Hong-yu

“…Oncogenic conversion of the RET (rearranged during transfection) tyrosine kinase is associated with several cancers. A fragment‐based chemical screen led to…”
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N‐Acetyl‐L‐Cysteine (NAC) Blunts Axitinib‐Related Adverse Effects in Preclinical Models of Glioblastoma by Formato, Alessia, Salbini, Maria, Orecchini, Elisa, Pellegrini, Manuela, Buccarelli, Mariachiara, Vitiani, Lucia Ricci, Giannetti, Stefano, Pallini, Roberto, D'Alessandris, Quintino Giorgio, Lauretti, Liverana, Martini, Maurizio, De Falco, Valentina, Levi, Andrea, Falchetti, Maria Laura, Mongiardi, Maria Patrizia

“…ABSTRACT Objective Axitinib is a tyrosine kinase inhibitor characterized by a strong affinity for Vascular Endothelial Growth Factor Receptors (VEGFRs). It was…”
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Effects of combined administration of rapamycin, tolvaptan, and AEZ-131 on the progression of polycystic disease in PCK rats by Sabbatini, Massimo, Russo, Luigi, Cappellaio, Francesco, Troncone, Giancarlo, Bellevicine, Claudio, De Falco, Valentina, Buonocore, Preziosa, Riccio, Eleonora, Bisesti, Vincenzo, Federico, Stefano, Pisani, Antonio

“…Both experimental and clinical studies have suggested that any potential treatment of polycystic kidney disease (PKD) should start early and last for a long…”
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Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics by Anand, Uttpal, Dey, Abhijit, Chandel, Arvind K. Singh, Sanyal, Rupa, Mishra, Amarnath, Pandey, Devendra Kumar, De Falco, Valentina, Upadhyay, Arun, Kandimalla, Ramesh, Chaudhary, Anupama, Dhanjal, Jaspreet Kaur, Dewanjee, Saikat, Vallamkondu, Jayalakshmi, Pérez de la Lastra, José M.

“…Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every…”
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Functional expression of the CXCR4 chemokine receptor is induced by RET PTC oncogenes and is a common event in human papillary thyroid carcinomas by CASTELLONE, Maria D, GUARINO, Valentina, FUSCO, Alfredo, SANTORO, Massimo, MELILLO, Rosa Marina, DE FALCO, Valentina, CARLOMAGNO, Francesca, BASOLO, Fulvio, FAVIANA, Pinuccia, KRUHOFFER, Mogens, ORNTOFT, Torben, RUSSELL, John P, ROTHSTEIN, Jay L

“…To identify genes involved in the transformation of thyroid follicular cells, we explored, using DNA oligonucleotide microarrays, the transcriptional response…”
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The Role of Nutrients in Prevention, Treatment and Post-Coronavirus Disease-2019 (COVID-19) by Motti, Maria Letizia, Tafuri, Domenico, Donini, Lorenzo, Masucci, Maria Teresa, De Falco, Valentina, Mazzeo, Filomena

“…SARS-CoV-2 virus, infecting human cells via its spike protein, causes Coronavirus disease 2019 (COVID-19). COVID-19 is characterized by shortness of breath,…”
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The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells by Melillo, Rosa Marina, Castellone, Maria Domenica, Guarino, Valentina, De Falco, Valentina, Cirafici, Anna Maria, Salvatore, Giuliana, Caiazzo, Fiorina, Basolo, Fulvio, Giannini, Riccardo, Kruhoffer, Mogens, Orntoft, Torben, Fusco, Alfredo, Santoro, Massimo

“…In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and activating mutations in the BRAF or RAS oncogenes are mutually…”
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Targeting the p90RSK/MDM2/p53 Pathway Is Effective in Blocking Tumors with Oncogenic Up-Regulation of the MAPK Pathway Such as Melanoma and Lung Cancer by Maietta, Immacolata, Viscusi, Eleonora, Laudati, Stefano, Iannaci, Giuseppe, D'Antonio, Antonio, Melillo, Rosa Marina, Motti, Maria Letizia, De Falco, Valentina

“…In most human tumors, the MAPK pathway is constitutively activated. Since p90RSK is downstream of MAPK, it is often hyperactive and capable of phosphorylating…”
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Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets by Cerrato, Aniello, De Falco, Valentina, Santoro, Massimo

“…Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the…”
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CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells by DE FALCO, Valentina, TAMBURRINO, Anna, VENTRE, Simona, CASTELLONE, Maria Domenica, MALEK, Mouhannad, MANIE, Serge N, SANTORO, Massimo

“…CD44 is a marker of cancer stem-like cells and epithelial-mesenchymal transition that is overexpressed in many cancer types, including thyroid carcinoma. At…”
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XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt by Shiozaki, Atsushi, Shen-Tu, Grace, Bai, Xiaohui, Iitaka, Daisuke, De Falco, Valentina, Santoro, Massimo, Keshavjee, Shaf, Liu, Mingyao

“…XB130, a novel adaptor protein, mediates RET/PTC chromosome rearrangement-related thyroid cancer cell proliferation and survival through…”
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Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene by Mendes Oliveira, Duarte, Grillone, Katia, Mignogna, Chiara, De Falco, Valentina, Laudanna, Carmelo, Biamonte, Flavia, Locane, Rosa, Corcione, Francesco, Fabozzi, Massimiliano, Sacco, Rosario, Viglietto, Giuseppe, Malanga, Donatella, Rizzuto, Antonia

“…Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to…”
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Corrigendum to ‘Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics’ [Genes & Diseases 10 (2023) 1367–1401] by Anand, Uttpal, Dey, Abhijit, Singh Chandel, Arvind K., Sanyal, Rupa, Mishra, Amarnath, Pandey, Devendra Kumar, De Falco, Valentina, Upadhyay, Arun, Kandimalla, Ramesh, Chaudhary, Anupama, Dhanjal, Jaspreet Kaur, Dewanjee, Saikat, Vallamkondu, Jayalakshmi, Pérez de la Lastra, José M.

“…[This corrects the article DOI: 10.1016/j.gendis.2022.02.007.]…”
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BRAF Is a Therapeutic Target in Aggressive Thyroid Carcinoma by SALVATORE, Giuliana, DE FALCO, Valentina, SALERNO, Paolo, NAPPI, Tito Claudio, PEPE, Stefano, TRONCONE, Giancarlo, CARLOMAGNO, Francesca, MELILLO, Rosa Marina, WILHELM, Scott M, SANTORO, Massimo

“…Purpose: Oncogenic conversion of BRAF occurs in ∼44% of papillary thyroid carcinomas and 24% of anaplastic thyroid carcinomas. In papillary thyroid carcinomas,…”
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Biological Role and Potential Therapeutic Targeting of the Chemokine Receptor CXCR4 in Undifferentiated Thyroid Cancer by DE FALCO, Valentina, GUARINO, Valentina, AVILLA, Elvira, DOMENICA CASTELLONE, Maria, SALERNO, Paolo, SALVATORE, Giuliana, FAVIANA, Pinuccia, BASOLO, Fulvio, SANTORO, Massimo, MARINA MELILLO, Rosa

“…Anaplastic thyroid carcinoma (ATC) is a rare thyroid cancer type with an extremely poor prognosis. Despite appropriate treatment, which includes surgery,…”
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Correction to: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene by Oliveira, Duarte Mendes, Grillone, Katia, Mignogna, Chiara, De Falco, Valentina, Laudanna, Carmelo, Biamonte, Flavia, Locane, Rosa, Corcione, Francesco, Fabozzi, Massimiliano, Sacco, Rosario, Viglietto, Giuseppe, Malanga, Donatella, Rizzuto, Antonia

“…In the publication of this article [1], there is an error in Fig. 7. The minus and plus signals are inverted which impairs understanding of the results…”
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The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells by Vitagliano, Donata, De Falco, Valentina, Tamburrino, Anna, Coluzzi, Sabrina, Troncone, Giancarlo, Chiappetta, Gennaro, Ciardiello, Fortunato, Tortora, Giampaolo, Fagin, James A, Ryan, Anderson J, Carlomagno, Francesca, Santoro, Massimo

“…Oncogenic conversion of the RET tyrosine kinase is a frequent feature of medullary thyroid carcinoma (MTC). ZD6474 (vandetanib) is an ATP-competitive inhibitor…”
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Functional Characterization of the Novel T599I-VKSRdel BRAF Mutation in a Follicular Variant Papillary Thyroid Carcinoma by De Falco, Valentina, Giannini, Riccardo, Tamburrino, Anna, Ugolini, Clara, Lupi, Cristiana, Puxeddu, Efisio, Santoro, Massimo, Basolo, Fulvio

“…Context: Mutations in BRAF are rare in the follicular variant of papillary thyroid carcinoma (FV-PTC). Objective: We identified and functionally characterized…”
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RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase by DE FALCO, Valentina, CASTELLONE, Maria Domenica, DE VITA, Gabriella, CIRAFICI, Anna Maria, HERSHMAN, Jerome M, GUERRERO, Carmen, FUSCO, Alfredo, MELILLO, Rosa Marina, SANTORO, Massimo

“…RET/papillary thyroid carcinoma (PTC) oncoproteins result from the in-frame fusion of the RET receptor tyrosine kinase with protein dimerization motifs encoded…”
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The Ca2+–calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC by Rusciano, Maria Rosaria, Salzano, Marcella, Monaco, Sara, Sapio, Maria Rosaria, Illario, Maddalena, De Falco, Valentina, Santoro, Massimo, Campiglia, Pietro, Pastore, Lucio, Fenzi, Gianfranco, Rossi, Guido, Vitale, Mario

“…RET/papillary thyroid carcinoma (PTC), TRK-T, or activating mutations of Ras and BRaf are frequent genetic alterations in PTC, all leading to the activation of…”
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