Search Results - "DE CASTRO, Ignacio Pérez"

Control of cell proliferation pathways by microRNAs by Bueno, María José, de Castro, Ignacio Pérez, Malumbres, Marcos

“…microRNAs (miRNAs) are small non-coding RNAs that regulate a large variety of cellular processes including differentiation, apoptosis and proliferation…”
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Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development by Fernández-Miranda, Gonzalo, Trakala, Marianna, Martín, Javier, Escobar, Beatriz, González, Alejandra, Ghyselinck, Norbert B, Ortega, Sagrario, Cañamero, Marta, Pérez de Castro, Ignacio, Malumbres, Marcos

“…Mitosis is controlled by multiple kinases that drive cell cycle progression and prevent chromosome mis-segregation. Aurora kinase B interacts with survivin,…”
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Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease by Gómez-Mariano, Gema, Matamala, Nerea, Martínez, Selene, Justo, Iago, Marcacuzco, Alberto, Jimenez, Carlos, Monzón, Sara, Cuesta, Isabel, Garfia, Cristina, Martínez, María Teresa, Huch, Meritxell, Pérez de Castro, Ignacio, Posada, Manuel, Janciauskiene, Sabina, Martínez-Delgado, Beatriz

“…Background and aims Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1…”
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Aurora A drives early signalling and vesicle dynamics during T-cell activation by Blas-Rus, Noelia, Bustos-Morán, Eugenio, Pérez de Castro, Ignacio, de Cárcer, Guillermo, Borroto, Aldo, Camafeita, Emilio, Jorge, Inmaculada, Vázquez, Jesús, Alarcón, Balbino, Malumbres, Marcos, Martín-Cófreces, Noa B., Sánchez-Madrid, Francisco

“…Aurora A is a serine/threonine kinase that contributes to the progression of mitosis by inducing microtubule nucleation. Here we have identified an unexpected…”
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Targeting cell cycle kinases for cancer therapy by de Cárcer, Guillermo, Pérez de Castro, Ignacio, Malumbres, Marcos

“…Many tumor-associated mutations result in the abnormal regulation of protein kinases involved in the progression throughout the cell division cycle. The…”
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SUMOylation modulates the function of Aurora-B kinase by Fernández-Miranda, Gonzalo, de Castro, Ignacio Pérez, Carmena, Mar, Aguirre-Portolés, Cristina, Ruchaud, Sandrine, Fant, Xavier, Montoya, Guillermo, Earnshaw, William C, Malumbres, Marcos

“…Aurora kinases are central regulators of mitotic-spindle assembly, chromosome segregation and cytokinesis. Aurora B is a member of the chromosomal passenger…”
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Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway by Bueno, María J., Gómez de Cedrón, Marta, Gómez-López, Gonzalo, Pérez de Castro, Ignacio, Di Lisio, Lorena, Montes-Moreno, Santiago, Martínez, Nerea, Guerrero, Manuel, Sánchez-Martínez, Ruth, Santos, Javier, Pisano, David G., Piris, Miguel Angel, Fernández-Piqueras, José, Malumbres, Marcos

“…Many mammalian transcripts contain target sites for multiple miRNAs, although it is not clear to what extent miRNAs may coordinately regulate single genes. We…”
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Consequences of Lmna Exon 4 Mutations in Myoblast Function by Gómez-Domínguez, Déborah, Epifano, Carolina, Miguel, Fernando de, Castaño, Albert García, Vilaplana-Martí, Borja, Martín, Alberto, Amarilla-Quintana, Sandra, Bertrand, Anne T, Bonne, Gisèle, Ramón-Azcón, Javier, Rodríguez-Milla, Miguel A, Pérez de Castro, Ignacio

“…Laminopathies are causally associated with mutations on the Lamin A/C gene ( ). To date, more than 400 mutations in have been reported in patients. These…”
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Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression by Bueno, María J., Pérez de Castro, Ignacio, Gómez de Cedrón, Marta, Santos, Javier, Calin, George A., Cigudosa, Juan C., Croce, Carlo M., Fernández-Piqueras, José, Malumbres, Marcos

“…The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal…”
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Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1) by Trakala, Marianna, Fernández-Miranda, Gonzalo, Pérez de Castro, Ignacio, Heeschen, Christopher, Malumbres, Marcos

“…Aurora kinase B is a critical component of the chromosomal passenger complex, which is involved in the regulation of microtubule-kinetochore attachments and…”
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Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals by DE CASTRO, Ignacio Pérez, AGUIRRE-PORTOLES, Cristina, FERNANDEZ-MIRANDA, Gonzalo, CANAMERO, Marta, COWLEY, Dale O, VAN DYKE, Terry, MALUMBRES, Marcos

“…Aurora-A is a kinase involved in the formation and maturation of the mitotic spindle and chromosome segregation. This kinase is frequently overexpressed in…”
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The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas by Segura-Collar, Berta, Gargini, Ricardo, Tovar-Ambel, Elena, Hernández-SanMiguel, Esther, Epifano, Carolina, Pérez de Castro, Ignacio, Hernández-Laín, Aurelio, Casas-Tintó, Sergio, Sánchez-Gómez, Pilar

“…Despite the high frequency of and genetic alterations in gliomas, little is known about their crosstalk during tumor progression. Here, we described a mutually…”
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Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression by Bueno, María J., Pérez de Castro, Ignacio, Gómez de Cedrón, Marta, Santos, Javier, Calin, George A., Cigudosa, Juan C., Croce, Carlo M., Fernández-Piqueras, José, Malumbres, Marcos

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Tpx2 Controls Spindle Integrity, Genome Stability, and Tumor Development by AGUIRRE-PORTOLES, Cristina, BIRD, Alexander W, HYMAN, Anthony, CANAMERO, Marta, DE CASTRO, Ignacio Pérez, MALUMBRES, Marcos

“…Tpx2 is a microtubule-associated protein that activates the cell-cycle kinase Aurora A and regulates the mitotic spindle. Overexpression of Tpx2 is associated…”
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Emerging cancer therapeutic opportunities by inhibiting mitotic kinases by Pérez de Castro, Ignacio, de Cárcer, Guillermo, Montoya, Guillermo, Malumbres, Marcos

“…Among cellular kinases, several cell cycle protein kinases play critical roles in mitotic entry and chromosome segregation. Inhibition of these proteins…”
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The Rgr oncogene induces tumorigenesis in transgenic mice by JIMENEZ, Maria, PEREZ DE CASTRO, Ignacio, BENET, Marta, GARCIA, Juan F, INGHIRAMI, Giorgio, PELLICER, Angel

“…To study the oncogenic potential of Rgr in vivo, we have generated several transgenic Rgr mouse lines, which express the oncogene under the control of…”
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Aurora kinase A inhibitors: promising agents in antitumoral therapy by Malumbres, Marcos, Pérez de Castro, Ignacio

“…Aurora proteins are serine/threonine kinases with critical functions during mitosis. Aurora A, one of the members of this family, participates in crucial…”
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Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers by Martín, Alberto, Epifano, Carolina, Vilaplana-Marti, Borja, Hernández, Iván, Macías, Rocío I. R., Martínez-Ramírez, Ángel, Cerezo, Ana, Cabezas-Sainz, Pablo, Garranzo-Asensio, Maria, Amarilla-Quintana, Sandra, Gómez-Domínguez, Déborah, Caleiras, Eduardo, Camps, Jordi, Gómez-López, Gonzalo, Gómez de Cedrón, Marta, Ramírez de Molina, Ana, Barderas, Rodrigo, Sánchez, Laura, Velasco-Miguel, Susana, Pérez de Castro, Ignacio

“…Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its immediate consequence, aneuploidy, trigger adverse effects on cellular…”
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A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy by Pérez de Castro, Ignacio, de Cárcer, Guillermo, Malumbres, Marcos

“…Tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key regulators of the cell cycle. Most known oncogenes and tumor…”
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PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis by Bivona, Trever G, Quatela, Steven E, Bodemann, Brian O, Ahearn, Ian M, Soskis, Michael J, Mor, Adam, Miura, John, Wiener, Heidi H, Wright, Latasha, Saba, Shahryar G, Yim, Duke, Fein, Adam, Pérez de Castro, Ignacio, Li, Chi, Thompson, Craig B, Cox, Adrienne D, Philips, Mark R

“…K-Ras associates with the plasma membrane (PM) through farnesylation that functions in conjunction with an adjacent polybasic sequence. We show that…”
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