Search Results - "DE BENEDICTIS, G"

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly by Rose, G, Dato, S, Altomare, K, Bellizzi, D, Garasto, S, Greco, V, Passarino, G, Feraco, E, Mari, V, Barbi, C, BonaFe, M, Franceschi, C, Tan, Q, Boiko, S, Yashin, A.I, De Benedictis, G

“…The human sirtuin 3 ( SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of…”
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S100B induces the release of pro-inflammatory cytokines in alveolar type I-like cells by Piazza, O, Leggiero, E, De Benedictis, G, Pastore, L, Salvatore, F, Tufano, R, De Robertis, E

“…S100B, a 21kDa cytosolic calcium-binding protein of the EF-hand type, present in high abundance in the brain, stimulates inflammatory responses in different…”
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Two-dimensional, M-mode and Doppler-derived echocardiographic parameters in sedated healthy growing female sheep by Poser, H, Semplicini, L, Benedictis, GM De, Gerardi, G, Contiero, B, Maschietto, N, Valerio, E, Milanesi, O, Semplicini, A, Bernardini, D

“…Despite the fact that sheep are a widely used animal model in cardiovascular research, reference values for transthoracic echocardiography in normal growing…”
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Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep by Bortolami, E., della Rocca, G., Di Salvo, A., Giorgi, M., Kim, T.W., Isola, M., De Benedictis, G.M.

“…•Six sheep were administered 4 and 6 mg/kg tramadol and saline intravenously.•Pharmacokinetic analysis and mechanical nociceptive threshold test were…”
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The effects of APOE and tau gene variability on risk of frontotemporal dementia by Bernardi, L., Maletta, R.G., Tomaino, C., Smirne, N., Di Natale, M., Perri, M., Longo, T., Colao, R., Curcio, S.A.M., Puccio, G., Mirabelli, M., Kawarai, T., Rogaeva, E., St. George Hyslop, P.H., Passarino, G., De Benedictis, G., Bruni, A.C.

“…Frontotemporal dementia (FTD) is a complex dementing syndrome whose genetic/non genetic risk factors are mostly unknown. Aim of the present work was to…”
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Do men and women follow different trajectories to reach extreme longevity? by Franceschi, C., Motta, L., Valensin, S., Rapisarda, R., Franzone, A., Berardelli, M., Motta, M., Monti, D., Bonafè, M., Ferrucci, L., Deiana, L., Pes, G. M., Carru, C., Desole, M. S., Barbi, C., Sartoni, G., Gemelli, C., Lescai, F., Olivieri, F., Marchegiani, F., Cardelli, M., Cavallone, L., Gueresi, P., Cossarizza, A., Troiano, L., Pini, G., Sansoni, P., Passeri, G., Lisa, R., Spazzafumo, L., Amadio, L., Giunta, S., Stecconi, R., Morresi, R., Viticchi, C., Mattace, R., De Benedictis, G., Baggio, G.

“…Gender accounts for important differences in the incidence and prevalence of a variety of age-related diseases. Considering people of far advanced age,…”
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Genes, Demography, and Life Span: The Contribution of Demographic Data in Genetic Studies on Aging and Longevity by Yashin, A.I., De Benedictis, G., Vaupel, J.W., Tan, Q., Andreev, K.F., Iachine, I.A., Bonafe, M., DeLuca, M., Valensin, S., Carotenuto, L., Franceschi, C.

“…In population studies on aging, the data on genetic markers are often collected for individuals from different age groups. The purpose of such studies is to…”
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Duration of efficacy and effect of implant location in adult queens treated with a 9.4 mg deslorelin subcutaneous implant by Baldan, A., Pereira, M., Pedrotti, V., Ferro, S., Gelli, D., Milani, C., A, Mollo, Fontaine, C., De Benedictis, G.M., Stelletta, C., Romagnoli, S.

“…Deslorelin is a GnRH-agonist used off-label for contraception in female cats. Little is known about duration and safety of the 9.4 mg subcutaneous implant in…”
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Pain alleviation during castration of piglets: a comparative study of different farm options by Gottardo, F, Scollo, A, Contiero, B, Ravagnani, A, Tavella, G, Bernardini, D, De Benedictis, G M, Edwards, S A

“…Pain alleviation associated with castration of piglets is an important welfare issue. The present study compares the effect of different approaches and…”
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A cluster analysis to define human aging phenotypes by PASSARINO, G, MONTESANTO, A, DE RANGO, F, GARASTO, S, BERARDELLI, M, DOMMA, F, MARI, V, FERACO, E, FRANCESCHI, C, DE BENEDICTIS, G

“…The definition of a precise and consistent aging phenotype that allows to measure the physical and cognitive decline, as well as the increase of mortality…”
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Genes and longevity: lessons from studies of centenarians by Yashin, A I, De Benedictis, G, Vaupel, J W, Tan, Q, Andreev, K F, Iachine, I A, Bonafe, M, Valensin, S, De Luca, M, Carotenuto, L, Franceschi, C

“…In population studies of aging, the data on genetic markers are often collected for individuals from different age groups. The idea of such studies is to…”
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Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype by Franceschi, C, Valensin, S, Lescai, F, Olivieri, F, Licastro, F, Grimaldi, L M, Monti, D, De Benedictis, G, Bonafè, M

“…The role of interleukin 1 (IL-1) and interleukin 6 (IL-6) in the pathogenesis of Alzheimer's disease (AD) is reviewed within the framework of "inflamm-aging",…”
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The Genetic Legacy of Paleolithic Homo sapiens sapiens in Extant Europeans: A Y Chromosome Perspective by Semino, Ornella, Passarino, Giuseppe, Oefner, Peter J., Lin, Alice A., Arbuzova, Svetlana, Beckman, Lars E., de Benedictis, Giovanna, Francalacci, Paolo, Kouvatsi, Anastasia, Limborska, Svetlana, Marcikiæ, Mladen, Mika, Anna, Mika, Barbara, Primorac, Dragan, Santachiara-Benerecetti, A. Silvana, Cavalli-Sforza, L. Luca, Underhill, Peter A.

“…A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of…”
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Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13 by Bellizzi, D., Dato, S., Cavalcante, P., Covello, G., Di Cianni, F., Passarino, G., Rose, G., De Benedictis, G.

“…The human SIRT3 gene contains an intronic VNTR enhancer whose variability is correlated with life span. The SIRT3 5′ flanking region encompasses the PSMD13…”
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The network and the remodeling theories of aging: historical background and new perspectives by Franceschi, C, Valensin, S, Bonafè, M, Paolisso, G, Yashin, A.I, Monti, D, De Benedictis, G

“…Two general theories, i.e. “the network theory of aging” (1989) and “the remodeling theory of aging” (1995), as well as their implications, new developments,…”
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Mitochondrial DNA Variability Modulates mRNA and Intra-Mitochondrial Protein Levels of HSP60 and HSP75: Experimental Evidence from Cybrid Lines by Bellizzi, D., Taverna, D., D'Aquila, P., De Blasi, S., De Benedictis, G.

“…To explore possible relationships between mitochondrial DNA (mtDNA) polymorphism and the expression levels of stress-responder nuclear genes we assembled five…”
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Genes, ageing and longevity in humans: problems, advantages and perspectives by Salvioli, S, Olivieri, F, Marchegiani, F, Cardelli, M, Santoro, A, Bellavista, E, Mishto, M, Invidia, L, Capri, M, Valensin, S, Sevini, F, Cevenini, E, Celani, L, Lescai, F, Gonos, E, Caruso, C, Paolisso, G, De Benedictis, G, Monti, D, Franceschi, C

“…Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible…”
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Spatial Analysis and Surname Analysis: Complementary Tools for Shedding Light on Human Longevity Patterns by Montesanto, A., Passarino, G., Senatore, A., Carotenuto, L., De Benedictis, G.

“…Summary Starting from the observation that human longevity patterns show regional variations, we applied Spatial Analysis (using the Geographic Information…”
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DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus by DE BENEDICTIS, G, FALCONE, E, MORELLINI, M, SANSONI, P, FRANCESCHI, C, ROSE, G, RUFFOLO, R, SPADAFORA, P, BAGGIO, G, BERTOLINI, S, MARI, D, MATTACE, R, MONTI, D

“…To identify possible genetic factors affecting human longevity we compared allele pools at two candidate loci for longevity between a sample of 143…”
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No evidence of association between frontotemporal dementia and major European mtDNA haplogroups by Rose, G., Longo, T., Maletta, R., Passarino, G., Bruni, A. C., De Benedictis, G.

“…Background and purpose:  Mitochondrial DNA (mtDNA) inherited variability (haplogroup/sub‐haplogroup) is currently emerging as not being neutral with respect to…”
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