Anticancer Potential of Palladium(II) Complexes With Schiff Bases Derived from 4-Aminoacetophenone Against Melanoma In Vitro

Melanoma represents a big challenge for clinical treatment. Besides being the most aggressive and the deadliest form of skin cancer, it is often refractory to commonly used anticancer drugs. Hence, developing new anti-cancer agents is crucial to improve refractory melanoma treatment. Studies using p...

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Bibliographic Details
Published in:	Anticancer research Vol. 39; no. 12; pp. 6693 - 6699
Main Authors:	Sarto, Luís Eduardo, DE Gois, Elba Pereira, DE Andrade, Gabriela Gomes, DE Almeida, Mateus Silveira, Freitas, Jennifer Tavares Jacon, DE Souza Reis Júnior, Antônio, Franco, Lilian Pereira, Torres, Claúdia, DE Almeida, Eduardo Tonon, Gouvêa, Cibele Marli Cação Paiva
Format:	Journal Article
Language:	English
Published:	Greece International Institute of Anticancer Research 01-12-2019
Subjects:	Acetophenones - chemistry Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - therapeutic use Antineoplastic drugs Antitumor activity Antitumor agents Biotechnology Cell Death Cell Line, Tumor Cell Survival - drug effects Cell viability Coordination compounds Cytology Cytotoxicity Drug Screening Assays, Antitumor Humans Imines In Vitro Techniques Ligands Melanoma Melanoma - drug therapy Morphology Organometallic Compounds - chemical synthesis Organometallic Compounds - therapeutic use Palladium Palladium - chemistry Palladium - therapeutic use Rhodamines Schiff Bases - chemistry Schiff Bases - therapeutic use Skin cancer Skin Neoplasms - drug therapy Synthesis metal complexes skin cancer cell viability cell death Antitumor effect
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Summary:	Melanoma represents a big challenge for clinical treatment. Besides being the most aggressive and the deadliest form of skin cancer, it is often refractory to commonly used anticancer drugs. Hence, developing new anti-cancer agents is crucial to improve refractory melanoma treatment. Studies using palladium(II) complexes have reported antitumor effects on cancer cells. In this study, we aimed to determine the cytotoxic effect of three novel synthesized Pd(II) complexes with Schiff bases derived from 4-aminoacetophenone on the MDA-MB-435 melanoma cell line. Cells were treated with ligand and Pd(II) complexes. Cell viability, morphology and death induction upon treatment were examined. Novel synthesized Pd(II) complexes led to decreased viability of cells. They also induced morphological alterations and cell death, mainly in the C3 complex. The novel synthesized complexes have a significant cytotoxic effect on cell line MDA-MB-435, especially C3 and can be considered as an antitumor agent for further studies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0250-7005 1791-7530
DOI:	10.21873/anticanres.13884