Search Results - "DAZA, Anthony"

Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis by Ruan, Xianhui, Yan, Wei, Cao, Minghui, Daza, Ray Anthony M., Fong, Miranda Y., Yang, Kaifu, Wu, Jun, Liu, Xuxiang, Palomares, Melanie, Wu, Xiwei, Li, Arthur, Chen, Yuan, Jandial, Rahul, Spitzer, Nicholas C., Hevner, Robert F., Wang, Shizhen Emily

“…Breast cancer metastasis to the brain is a clinical challenge rising in prevalence. However, the underlying mechanisms, especially how cancer cells adapt a…”
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Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity by Frost, Jennifer M, Dart, Michael J, Tietje, Karin R, Garrison, Tiffany R, Grayson, George K, Daza, Anthony V, El-Kouhen, Odile F, Yao, Betty B, Hsieh, Gin C, Pai, Madhavi, Zhu, Chang Z, Chandran, Prasant, Meyer, Michael D

“…Several 3-acylindoles with high affinity for the CB2 cannabinoid receptor and selectivity over the CB1 receptor have been prepared. A variety of 3-acyl…”
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Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging by Yao, Betty B, Hsieh, Gin, Daza, Anthony V, Fan, Yihong, Grayson, George K, Garrison, Tiffany Runyan, El Kouhen, Odile, Hooker, Bradley A, Pai, Madhavi, Wensink, Erica J, Salyers, Anita K, Chandran, Prasant, Zhu, Chang Z, Zhong, Chengmin, Ryther, Keith, Gallagher, Megan E, Chin, Chih-Liang, Tovcimak, Ann E, Hradil, Vincent P, Fox, Gerard B, Dart, Michael J, Honore, Prisca, Meyer, Michael D

“…Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB(2) receptor activation have been largely derived from the use of…”
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Indol-3-yl-tetramethylcyclopropyl Ketones: Effects of Indole Ring Substitution on CB2 Cannabinoid Receptor Activity by Frost, Jennifer M, Dart, Michael J, Tietje, Karin R, Garrison, Tiffany R, Grayson, George K, Daza, Anthony V, El-Kouhen, Odile F, Miller, Loan N, Li, Lanlan, Yao, Betty B, Hsieh, Gin C, Pai, Madhavi, Zhu, Chang Z, Chandran, Prasant, Meyer, Michael D

“…A series of potent indol-3-yl-tetramethylcyclopropyl ketones have been prepared as CB2 cannabinoid receptor ligands. Two unsubstituted indoles (5, 32) were the…”
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Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators by Buckner, Steven A, Milicic, Ivan, Daza, Anthony V, Coghlan, Michael J, Gopalakrishnan, Murali

“…A hallmark for unstable bladder contractions is hyperexcitability and changes in the nature of spontaneous phasic activity of the bladder smooth muscle. In…”
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Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management by Nelson, Derek W., Frost, Jennifer M., Tietje, Karin R., Florjancic, Alan S., Ryther, Keith, Carroll, William A., Dart, Michael J., Daza, Anthony V., Hooker, Bradley A., Grayson, George K., Fan, Yihong, Garrison, Tiffany R., El-Kouhen, Odile F., Yao, Betty, Pai, Madhavi, Chandran, Prasant, Zhu, Chang, Hsieh, Gin C., Meyer, Michael D.

“…SAR studies on a series of thiophene amide derivatives provided CB2 receptor agonists. The activity of the compounds was characterized by radioligand binding…”
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Characterization of human cannabinoid CB2 receptor coupled to chimeric Gαqi5 and Gαqo5 proteins by MALYSZ, John, DAZA, Anthony V, KAGE, Karen, GRAYSON, George K, YAO, Betty B, MEYER, Michael D, GOPALAKRISHNAN, Murali

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Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener by Altenbach, Robert J, Brune, Michael E, Buckner, Steven A, Coghlan, Michael J, Daza, Anthony V, Fabiyi, Adebola, Gopalakrishnan, Murali, Henry, Rodger F, Khilevich, Albert, Kort, Michael E, Milicic, Ivan, Scott, Victoria E, Smith, Jamie C, Whiteaker, Kristi L, Carroll, William A

“…Structure−activity relationships were investigated on the tricyclic dihydropyridine (DHP) KATP openers…”
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Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle by Malysz, John, Buckner, Steven A, Daza, Anthony V, Milicic, Ivan, Perez-Medrano, Arturo, Gopalakrishnan, Murali

“…Calcium activated K(+) channels (K(Ca) channels) are found in a variety of smooth muscle tissues, the most characterized of which are the large conductance…”
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Synthesis and Structure−Activity Relationships of a Novel Series of Tricyclic Dihydropyridine-Based KATP Openers That Potently Inhibit Bladder Contractions in Vitro by Carroll, William A, Agrios, Konstantinos A, Altenbach, Robert J, Buckner, Steven A, Chen, Yiyuan, Coghlan, Michael J, Daza, Anthony V, Drizin, Irene, Gopalakrishnan, Murali, Henry, Rodger F, Kort, Michael E, Kym, Philip R, Milicic, Ivan, Smith, Jamie C, Tang, Rui, Turner, Sean C, Whiteaker, Kristi L, Zhang, Henry, Sullivan, James P

“…Structure−activity relationships were investigated on a novel series of tricyclic dihydropyridine-containing KATP openers. This diverse group of analogues,…”
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(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization by Gopalakrishnan, Murali, Buckner, Steven A, Whiteaker, Kristi L, Shieh, Char-Chang, Molinari, Eduardo J, Milicic, Ivan, Daza, Anthony V, Davis-Taber, Rachel, Scott, Victoria E, Sellers, Donna, Chess-Williams, Russ, Chapple, Christopher R, Liu, Yi, Liu, Dong, Brioni, Jorge D, Sullivan, James P, Williams, Michael, Carroll, William A, Coghlan, Michael J

“…Alterations in the myogenic activity of the bladder smooth muscle are thought to serve as a basis for the involuntary detrusor contractions associated with the…”
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Pharmacological and molecular analysis of ATP-sensitive K + channels in the pig and human detrusor by Buckner, Steven A, Milicic, Ivan, Daza, Anthony, Davis-Taber, Rachel, Scott, Victoria E.S, Sullivan, James P, Brioni, Jorge D

“…The pharmacological and molecular properties of ATP-sensitive K + channels present in pig detrusor smooth muscle were investigated. In isolated pig detrusor…”
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ABT-866, a novel α1A-adrenoceptor agonist with antagonist properties at the α1B- and α1D-adrenoceptor subtypes by Buckner, Steven A, Milicic, Ivan, Daza, Anthony V, Meyer, Michael D, Altenbach, Robert J, Williams, Michael, Sullivan, James P, Brioni, Jorge D

“…N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide, maleate (ABT-866) is a novel α1-adrenoceptor agent with mixed pharmacological properties in vitro…”
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Synthesis and Structure−Activity Studies on N-[5-(1H-Imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an Imidazole-Containing α1A-Adrenoceptor Agonist by Altenbach, Robert J, Khilevich, Albert, Kolasa, Teodozyj, Rohde, Jeffrey J, Bhatia, Pramila A, Patel, Meena V, Searle, Xenia B, Yang, Fan, Bunnelle, William H, Tietje, Karin, Bayburt, Erol K, Carroll, William A, Meyer, Michael D, Henry, Rodger, Buckner, Steven A, Kuk, Jane, Daza, Anthony V, Milicic, Ivan V, Cain, John C, Kang, Chae H, Ireland, Lynne M, Carr, Tracy L, Miller, Thomas R, Hancock, Arthur A, Nakane, Masaki, Esbenshade, Timothy A, Brune, Michael E, O'Neill, Alyssa B, Gauvin, Donna M, Katwala, Sweta P, Holladay, Mark W, Brioni, Jorge D, Sullivan, James P

“…Structure−activity studies were performed on the α1A-adrenoceptor (AR) selective agonist…”
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In vitro and in vivo characterization of a novel naphthylamide ATP‐sensitive K+ channel opener, A‐151892 by Gopalakrishnan, Murali, Buckner, Steven A, Shieh, Char‐Chang, Fey, Thomas, Fabiyi, Adebola, Whiteaker, Kristi L, Davis‐Taber, Rachel, Milicic, Ivan, Daza, Anthony V, Scott, Victoria E S, Castle, Neil A, Printzenhoff, David, London, Brecht, Turner, Sean C, Carroll, William A, Sullivan, James P, Coghlan, Michael J, Brune, Michael E

“…Openers of ATP‐sensitive K+ channels are of interest in several therapeutic indications including overactive bladder and other lower urinary tract disorders…”
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N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1), a Novel α1-Adrenoceptor Ligand with an Enhanced in Vitro and in Vivo Profile Relative to Phenylpropanolamine and Midodrine by Altenbach, Robert J, Khilevich, Albert, Meyer, Michael D, Buckner, Steven A, Milicic, Ivan, Daza, Anthony V, Brune, Michael E, O'Neill, Alyssa B, Gauvin, Donna M, Cain, John C, Nakane, Masaki, Holladay, Mark W, Williams, Michael, Brioni, Jorge D, Sullivan, James P

“…N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1) is a novel α1 agent having the unique profile of α1A (rabbit urethra, EC50 = 0.60 μM)…”
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Structure–activity relationship of a novel class of naphthyl amide KATP channel openers by Turner, Sean C, Carroll, William A, White, Tammie K, Brune, Michael E, Buckner, Steven A, Gopalakrishnan, Murali, Fabiyi, Adebola, Coghlan, Michael J, Scott, Victoria E, Castle, Neil A, Daza, Anthony V, Milicic, Ivan, Sullivan, James P

“…We have discovered a novel series of N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl] amides that are potent openers of K ATP channels…”
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Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide KATP Channel Openers:  Discovery of (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637), a Potent KATP Opener That Selectively Inhibits Spontaneous Bladder Contractions by Carroll, William A, Altenbach, Robert J, Bai, Hao, Brioni, Jorge D, Brune, Michael E, Buckner, Steven A, Cassidy, Christopher, Chen, Yiyuan, Coghlan, Michael J, Daza, Anthony V, Drizin, Irene, Fey, Thomas A, Fitzgerald, Michael, Gopalakrishnan, Murali, Gregg, Robert J, Henry, Rodger F, Holladay, Mark W, King, Linda L, Kort, Michael E, Kym, Philip R, Milicic, Ivan, Tang, Rui, Turner, Sean C, Whiteaker, Kristi L, Yi, Lin, Zhang, Henry, Sullivan, James P

“…Structure−activity relationships were investigated on a novel series of sulfonyldihydropyridine-containing KATP openers. Ring sizes, absolute stereochemistry,…”
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Species comparison and pharmacological characterization of rat and human CB 2 cannabinoid receptors by Mukherjee, Sutapa, Adams, Monique, Whiteaker, Kristi, Daza, Anthony, Kage, Karen, Cassar, Steven, Meyer, Michael, Yao, Betty Bei

“…Pharmacological effects of cannabinoid ligands are thought to be mediated through cannabinoid CB 1 and CB 2 receptor subtypes. Sequence analysis revealed that…”
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Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors by MUKHERJEE, Sutapa, ADAMS, Monique, WHITEAKER, Kristi, DAZA, Anthony, KAGE, Karen, CASSAR, Steven, MEYER, Michael, YAO, Betty Bei

“…Pharmacological effects of cannabinoid ligands are thought to be mediated through cannabinoid CB1 and CB2 receptor subtypes. Sequence analysis revealed that…”
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