Search Results - "DAWSON, T. M"

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 by Galluzzi, L, Vitale, I, Abrams, J M, Alnemri, E S, Baehrecke, E H, Blagosklonny, M V, Dawson, T M, Dawson, V L, El-Deiry, W S, Fulda, S, Gottlieb, E, Green, D R, Hengartner, M O, Kepp, O, Knight, R A, Kumar, S, Lipton, S A, Lu, X, Madeo, F, Malorni, W, Mehlen, P, Nuñez, G, Peter, M E, Piacentini, M, Rubinsztein, D C, Shi, Y, Simon, H-U, Vandenabeele, P, White, E, Yuan, J, Zhivotovsky, B, Melino, G, Kroemer, G

“…In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the…”
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β-Variational autoencoders and transformers for reduced-order modelling of fluid flows by Solera-Rico, Alberto, Sanmiguel Vila, Carlos, Gómez-López, Miguel, Wang, Yuning, Almashjary, Abdulrahman, Dawson, Scott T. M., Vinuesa, Ricardo

“…Variational autoencoder architectures have the potential to develop reduced-order models for chaotic fluid flows. We propose a method for learning compact and…”
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MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway by Xiao, J, Li, Y, Prandovszky, E, Karuppagounder, S.S, Talbot, C.C, Dawson, V.L, Dawson, T.M, Yolken, R.H

“…Highlights • We examine changes of over 1000 miRNAs in human neural cells by Toxoplasma infection. • MiR-132 is highly upregulated by all three prototype…”
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Identification through high‐throughput screening of 4'‐methoxyflavone and 3',4'‐dimethoxyflavone as novel neuroprotective inhibitors of parthanatos by Fatokun, A A, Liu, J O, Dawson, V L, Dawson, T M

“…Background and Purpose The current lack of disease‐modifying therapeutics to manage neurological and neurodegenerative conditions justifies the development of…”
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Psychiatric comorbidities in patients with Parkinson disease and psychosis by MARSH, L, WILLIAMS, J. R, ROCCO, M, GRILL, S, MUNRO, C, DAWSON, T. M

“…To determine the prevalence and impact of comorbid psychiatric disturbances in Parkinson disease (PD) patients with psychosis. Subject data were derived from a…”
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Data-Driven Pulsatile Blood Flow Physics with Dynamic Mode Decomposition by Habibi, Milad, Dawson, Scott T. M., Arzani, Amirhossein

“…Dynamic mode decomposition (DMD) is a purely data-driven and equation-free technique for reduced-order modeling of dynamical systems and fluid flow. DMD finds…”
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Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity by Nucifora, Frederick C., Sasaki, Masayuki, Peters, Matthew F., Huang, Hui, Cooper, Jillian K., Yamada, Mitsunori, Takahashi, Hitoshi, Tsuji, Shoji, Troncoso, Juan, Dawson, Valina L., Dawson, Ted M., Ross, Christopher A.

“…Expanded polyglutamine repeats have been proposed to cause neuronal degeneration in Huntington's disease (HD) and related disorders, through abnormal…”
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Myoclonus-dystonia and Silver-Russell syndrome resulting from maternal uniparental disomy of chromosome 7 by Sheridan, MB, Bytyci Telegrafi, A, Stinnett, V, Umeh, CC, Mari, Z, Dawson, TM, Bodurtha, J, Batista, DAS

“…Myoclonus‐dystonia (M‐D) is a movement disorder that is often associated with mutations in epsilon‐sarcoglycan (SGCE), a maternally imprinted gene at 7q21.3…”
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Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment by Ravina, B M, Fagan, S C, Hart, R G, Hovinga, C A, Murphy, D D, Dawson, T M, Marler, J R

“…Current therapies for PD ameliorate symptoms in the early phases of disease but become less effective over time, as the underlying disease progresses…”
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Nitric oxide in neurodegeneration by Dawson, V L, Dawson, T M

“…Nitric oxide (NO) is a unique biological messenger molecule which mediates diverse physiologic roles. NO mediates blood vessel relaxation by endothelium,…”
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The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders by Chung, Kenny K.K, Dawson, Valina L, Dawson, Ted M

“…A unifying feature of neurodegenerative diseases is the abnormal accumulation and processing of mutant or damaged intra- and extracellular proteins; this leads…”
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Parkin and defective ubiquitination in Parkinson's disease by Dawson, T M

“…Parkinson's Disease (PD) is a common neurodegenerative disorder that is characterized by the progressive loss of dopamine (DA) neurons. Accompanying the loss…”
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Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures by Dawson, VL, Dawson, TM, Bartley, DA, Uhl, GR, Snyder, SH

“…In addition to mediating several physiological functions, nitric oxide (NO) has been implicated in the cytotoxicities observed following activation of…”
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Targeted disruption of the neuronal nitric oxide synthase gene by Huang, P L, Dawson, T M, Bredt, D S, Snyder, S H, Fishman, M C

“…By homologous recombination, we have generated mice that lack the neuronal nitric oxide synthase (NOS) gene. Neuronal NOS expression and NADPH-diaphorase (NDP)…”
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Nitric Oxide Mediates Glutamate Neurotoxicity in Primary Cortical Cultures by Dawson, Valina L., Dawson, Ted M., London, Edythe D., Bredt, David S., Snyder, Solomon H.

“…Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels, cytotoxicity of activated macrophages, and formation of cGMP by…”
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Nitric oxide synthase in models of focal ischemia by SAMDANI, A. F, DAWSON, T. M, DAWSON, V. L

“…Cessation of blood flow to the brain, for even a few minutes, sets in motion a potential reversible cascade of events resulting in neuronal cell death. Oxygen…”
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Cortical Interneurons Become Activated by Deafferentation and Instruct the Apoptosis of Pyramidal Neurons by Koliatsos, V. E., Dawson, T. M., Kecojevic, A., Zhou, Yueping, Wang, Yi-Feei, K.-X. Huang, Snyder, Solomon H.

“…Unlike peripheral nervous system neurons and certain groups of nerve cells in the CNS, cortical projection neurons are tolerant of axonal lesions. This…”
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Nitric Oxide Synthase and Neuronal NADPH Diaphorase are Identical in Brain and Peripheral Tissues by DAWSON, T. M, BREDT, D. S, FOTUHI, M, HWANG, P. M, SNYDER, S. H

“…NADPH diaphorase staining neurons, uniquely resistant to toxic insults and neurodegenerative disorders, have been colocalized with neurons in the brain and…”
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Role of Neuronal Nitric Oxide in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Dopaminergic Neurotoxicity by Przedborski, Serge, Jackson-Lewis, Vernice, Yokoyama, Rina, Shibata, Toshihiro, Dawson, Valina L., Dawson, Ted M.

“…1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes nigrostriatal dopaminergic pathway damage similar to that observed in Parkinson disease (PD). To…”
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Poly(ADP-ribosyl)ation regulation of life and death in the nervous system by Koh, D W, Dawson, T M, Dawson, V L

“…Poly(ADP-ribosyl)ation is required by multicellular eukaryotes to ensure genomic integrity under conditions of mild to moderate genotoxic stress. However,…”
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