Search Results - "DAVIS, Lea K"

Weldon, Bateson, and the origins of genetics: Reflections on the unraveling and rebuilding of a scientific community by Davis, Lea K

“…“Science, like most forms of human activity, is occasionally liable to lose sight of its ultimate ends under a flood of controversy, the strugglings of…”
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Sex modifies the effect of genetic risk scores for polycystic ovary syndrome on metabolic phenotypes by Actkins, Ky'Era V, Jean-Pierre, Genevieve, Aldrich, Melinda C, Velez Edwards, Digna R, Davis, Lea K

“…Females with polycystic ovary syndrome (PCOS), the most common endocrine disorder in women, have an increased risk of developing cardiometabolic disorders such…”
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Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization by Pathak, Gita A., Singh, Kritika, Miller-Fleming, Tyne W., Wendt, Frank R., Ehsan, Nava, Hou, Kangcheng, Johnson, Ruth, Lu, Zeyun, Gopalan, Shyamalika, Yengo, Loic, Mohammadi, Pejman, Pasaniuc, Bogdan, Polimanti, Renato, Davis, Lea K., Mancuso, Nicholas

“…Despite rapid progress in characterizing the role of host genetics in SARS-Cov-2 infection, there is limited understanding of genes and pathways that…”
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Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation by Gao, Jianjun, Davis, Lea K, Hart, Amy B, Sanchez-Roige, Sandra, Han, Lide, Cacioppo, John T, Palmer, Abraham A

“…Loneliness is a complex biological trait that has been associated with numerous negative health outcomes. The measurement and environmental determinants of…”
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A genome-wide association study of polycystic ovary syndrome identified from electronic health records by Zhang, Yanfei, Ho, Kevin, Keaton, Jacob M., Hartzel, Dustin N., Day, Felix, Justice, Anne E., Josyula, Navya S., Pendergrass, Sarah A., Actkins, Ky'Era, Davis, Lea K., Velez Edwards, Digna R., Holohan, Brody, Ramirez, Andrea, Stanaway, Ian B., Crosslin, David R., Jarvik, Gail P., Sleiman, Patrick, Hakonarson, Hakon, Williams, Marc S., Lee, Ming Ta Michael

“…Polycystic ovary syndrome is the most common endocrine disorder affecting women of reproductive age. A number of criteria have been developed for clinical…”
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Examination of the shared genetic basis of anorexia nervosa and obsessive–compulsive disorder by Yilmaz, Zeynep, Halvorsen, Matthew, Bryois, Julien, Yu, Dongmei, Thornton, Laura M., Zerwas, Stephanie, Micali, Nadia, Moessner, Rainald, Burton, Christie L., Zai, Gwyneth, Erdman, Lauren, Kas, Martien J., Arnold, Paul D., Davis, Lea K., Knowles, James A., Breen, Gerome, Scharf, Jeremiah M., Nestadt, Gerald, Mathews, Carol A., Bulik, Cynthia M., Mattheisen, Manuel, Crowley, James J.

“…Anorexia nervosa (AN) and obsessive–compulsive disorder (OCD) are often comorbid and likely to share genetic risk factors. Hence, we examine their shared…”
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Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting by Mack, Taralynn, Sanchez-Roige, Sandra, Davis, Lea K.

“…Anorexia nervosa (AN) is a psychiatric disorder defined by anthropometric symptoms, such as low body weight, and cognitive-behavioral symptoms, such as…”
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Contextualizing genetic risk score for disease screening and rare variant discovery by Zhou, Dan, Yu, Dongmei, Scharf, Jeremiah M., Mathews, Carol A., McGrath, Lauren, Cook, Edwin, Lee, S. Hong, Davis, Lea K., Gamazon, Eric R.

“…Studies of the genetic basis of complex traits have demonstrated a substantial role for common, small-effect variant polygenic burden (PB) as well as…”
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The physical and psychiatric health conditions related to autism genetic scores, across genetic ancestries, sexes and age-groups in electronic health records by Niarchou, Maria, Miller-Fleming, Tyne, Malow, Beth A, Davis, Lea K

“…Although polygenic scores (PGS) for autism have been related to various psychiatric and medical conditions, most studies to date have been conducted in…”
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Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records by Niarchou, Maria, Sanchez-Roige, Sandra, Reddy, India A., Reese, Thomas J., Marcovitz, David, Davis, Lea K.

“…Despite the benefits associated with longer buprenorphine treatment duration (i.e., >180 days) (BTD) for opioid use disorder (OUD), retention remains poor…”
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Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction by Braun, Alice, Shekhar, Sudhanshu, Levey, Daniel F., Straub, Peter, Kraft, Julia, Panagiotaropoulou, Georgia M., Heilbron, Karl, Awasthi, Swapnil, Meleka Hanna, Rafael, Hoffmann, Sarah, Stein, Maike, Lehnerer, Sophie, Mergenthaler, Philipp, Elnahas, Abdelrahman G., Topaloudi, Apostolia, Koromina, Maria, Palviainen, Teemu, Asbjornsdottir, Bergrun, Stefansson, Hreinn, Skuladóttir, Astros Th, Jónsdóttir, Ingileif, Stefansson, Kari, Reis, Kadri, Esko, Tõnu, Palotie, Aarno, Leypoldt, Frank, Stein, Murray B., Fontanillas, Pierre, Kaprio, Jaakko, Gelernter, Joel, Davis, Lea K., Paschou, Peristera, Tannemaat, Martijn R., Verschuuren, Jan J.G.M., Kuhlenbäumer, Gregor, Gregersen, Peter K., Huijbers, Maartje G., Stascheit, Frauke, Meisel, Andreas, Ripke, Stephan

“…Myasthenia gravis (MG) is a rare autoantibody-mediated disease affecting the neuromuscular junction. We performed a genome-wide association study of 5708 MG…”
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Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease by Dennis, Jessica K, Sealock, Julia M, Straub, Peter, Lee, Younga H, Hucks, Donald, Actkins, Ky'Era, Faucon, Annika, Feng, Yen-Chen Anne, Ge, Tian, Goleva, Slavina B, Niarchou, Maria, Singh, Kritika, Morley, Theodore, Smoller, Jordan W, Ruderfer, Douglas M, Mosley, Jonathan D, Chen, Guanhua, Davis, Lea K

“…Clinical laboratory (lab) tests are used in clinical practice to diagnose, treat, and monitor disease conditions. Test results are stored in electronic health…”
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Developing a phenotype risk score for tic disorders in a large, clinical biobank by Miller-Fleming, Tyne W., Allos, Annmarie, Gantz, Emily, Yu, Dongmei, Isaacs, David A., Mathews, Carol A., Scharf, Jeremiah M., Davis, Lea K.

“…Tics are a common feature of early-onset neurodevelopmental disorders, characterized by involuntary and repetitive movements or sounds. Despite affecting up to…”
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Dense phenotyping from electronic health records enables machine learning-based prediction of preterm birth by Abraham, Abin, Le, Brian, Kosti, Idit, Straub, Peter, Velez-Edwards, Digna R, Davis, Lea K, Newton, J M, Muglia, Louis J, Rokas, Antonis, Bejan, Cosmin A, Sirota, Marina, Capra, John A

“…Identifying pregnancies at risk for preterm birth, one of the leading causes of worldwide infant mortality, has the potential to improve prenatal care…”
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Structural Architecture of SNP Effects on Complex Traits by Gamazon, Eric R., Cox, Nancy J., Davis, Lea K.

“…Despite the discovery of copy-number variation (CNV) across the genome nearly 10 years ago, current SNP-based analysis methodologies continue to collapse the…”
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Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry by Burns, Kharis, Mullin, Benjamin H, Moolhuijsen, Loes M E, Laisk, Triin, Tyrmi, Jaakko S, Cui, Jinrui, Actkins, Ky'Era V, Louwers, Yvonne V, Davis, Lea K, Dudbridge, Frank, Azziz, Ricardo, Goodarzi, Mark O, Laivuori, Hannele, Mägi, Reedik, Visser, Jenny A, Laven, Joop S E, Wilson, Scott G, Day, Felix R, Stuckey, Bronwyn G A

“…Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder with a substantial genetic component. However, the clinical manifestations of PCOS are…”
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A dimensional perspective on the genetics of obsessive-compulsive disorder by Strom, Nora I., Soda, Takahiro, Mathews, Carol A., Davis, Lea K.

“…This review covers recent findings in the genomics of obsessive-compulsive disorder (OCD), obsessive-compulsive symptoms, and related traits from a dimensional…”
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Development and multi-site external validation of a generalizable risk prediction model for bipolar disorder by Walsh, Colin G., Ripperger, Michael A., Hu, Yirui, Sheu, Yi-han, Lee, Hyunjoon, Wilimitis, Drew, Zheutlin, Amanda B., Rocha, Daniel, Choi, Karmel W., Castro, Victor M., Kirchner, H. Lester, Chabris, Christopher F., Davis, Lea K., Smoller, Jordan W.

“…Bipolar disorder is a leading contributor to disability, premature mortality, and suicide. Early identification of risk for bipolar disorder using…”
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The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene by Bagheri, Minoo, Wang, Chuan, Shi, Mingjian, Manouchehri, Ali, Murray, Katherine T., Murphy, Matthew B., Shaffer, Christian M., Singh, Kritika, Davis, Lea K., Jarvik, Gail P., Stanaway, Ian B., Hebbring, Scott, Reilly, Muredach P., Gerszten, Robert E., Wang, Thomas J., Mosley, Jonathan D., Ferguson, Jane F.

“…Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the…”
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Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose by Bosma, Karin J, Rahim, Mohsin, Singh, Kritika, Goleva, Slavina B, Wall, Martha L, Xia, Jing, Syring, Kristen E, Oeser, James K, Poffenberger, Greg, McGuinness, Owen P, Means, Anna L, Powers, Alvin C, Li, Wen-hong, Davis, Lea K, Young, Jamey D, O’Brien, Richard M

“…The G6PC1, G6PC2 and G6PC3 genes encode distinct glucose-6-phosphatase catalytic subunit (G6PC) isoforms. In mice, germline deletion of G6pc2 lowers fasting…”
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