Search Results - "DAVIS, James G"

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity by LAMMING, Dudley W, LAN YE, GUERTIN, David A, SABATINI, David M, BAUR, Joseph A, KATAJISTO, Pekka, GONCALVES, Marcus D, SAITOH, Maki, STEVENS, Deanna M, DAVIS, James G, SALMON, Adam B, RICHARDSON, Arlan, AHIMA, Rexford S

“…Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends the life spans of yeast, flies, and mice. Calorie restriction, which…”
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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle by Frederick, David W., Loro, Emanuele, Liu, Ling, Davila, Antonio, Chellappa, Karthikeyani, Silverman, Ian M., Quinn, William J., Gosai, Sager J., Tichy, Elisia D., Davis, James G., Mourkioti, Foteini, Gregory, Brian D., Dellinger, Ryan W., Redpath, Philip, Migaud, Marie E., Nakamaru-Ogiso, Eiko, Rabinowitz, Joshua D., Khurana, Tejvir S., Baur, Joseph A.

“…NAD is an obligate co-factor for the catabolism of metabolic fuels in all cell types. However, the availability of NAD in several tissues can become limited…”
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Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration by Mukherjee, Sarmistha, Chellappa, Karthikeyani, Moffitt, Andrea, Ndungu, Joan, Dellinger, Ryan W., Davis, James G., Agarwal, Beamon, Baur, Joseph A.

“…The regenerative capacity of the liver is essential for recovery from surgical resection or injuries induced by trauma or toxins. During liver regeneration,…”
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SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function by Price, Nathan L., Gomes, Ana P., Ling, Alvin J.Y., Duarte, Filipe V., Martin-Montalvo, Alejandro, North, Brian J., Agarwal, Beamon, Ye, Lan, Ramadori, Giorgio, Teodoro, Joao S., Hubbard, Basil P., Varela, Ana T., Davis, James G., Varamini, Behzad, Hafner, Angela, Moaddel, Ruin, Rolo, Anabela P., Coppari, Roberto, Palmeira, Carlos M., de Cabo, Rafael, Baur, Joseph A., Sinclair, David A.

“…Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To…”
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Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons by Zhang, Jing, Zhu, Yan, Zhan, Guanxia, Fenik, Polina, Panossian, Lori, Wang, Maxime M, Reid, Shayla, Lai, David, Davis, James G, Baur, Joseph A, Veasey, Sigrid

“…Modern society enables a shortening of sleep times, yet long-term consequences of extended wakefulness on the brain are largely unknown. Essential for optimal…”
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Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue by Tran, Cassie M, Mukherjee, Sarmistha, Ye, Lan, Frederick, David W, Kissig, Megan, Davis, James G, Lamming, Dudley W, Seale, Patrick, Baur, Joseph A

“…Rapamycin extends life span in mice, yet paradoxically causes lipid dysregulation and glucose intolerance through mechanisms that remain incompletely…”
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Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress by Madaris, Travis R., Venkatesan, Manigandan, Maity, Soumya, Stein, Miriam C., Vishnu, Neelanjan, Venkateswaran, Mridula K., Davis, James G., Ramachandran, Karthik, Uthayabalan, Sukanthathulse, Allen, Cristel, Osidele, Ayodeji, Stanley, Kristen, Bigham, Nicholas P., Bakewell, Terry M., Narkunan, Melanie, Le, Amy, Karanam, Varsha, Li, Kang, Mhapankar, Aum, Norton, Luke, Ross, Jean, Aslam, M. Imran, Reeves, W. Brian, Singh, Brij B., Caplan, Jeffrey, Wilson, Justin J., Stathopulos, Peter B., Baur, Joseph A., Madesh, Muniswamy

“…The most abundant cellular divalent cations, Mg2+ (mM) and Ca2+ (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of…”
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Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism by Naidoo, Nirinjini, Davis, James G., Zhu, Jingxu, Yabumoto, Maya, Singletary, Kristan, Brown, Marishka, Galante, Raymond, Agarwal, Beamon, Baur, Joseph A.

“…Summary Sleep disruption has detrimental effects on glucose metabolism through pathways that remain poorly defined. Although numerous studies have examined the…”
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NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury by Doke, Tomohito, Mukherjee, Sarmistha, Mukhi, Dhanunjay, Dhillon, Poonam, Abedini, Amin, Davis, James G., Chellappa, Karthikeyani, Chen, Beishan, Baur, Joseph A., Susztak, Katalin

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Effects of Dietary Antioxidant Supplementation on the Development of Malignant Lymphoma and Other Neoplastic Lesions in Mice Exposed to Proton or Iron-Ion Radiation by Kennedy, Ann R., Davis, James G., Carlton, William, Ware, Jeffrey H.

“…Kennedy, A. R., Davis, J. G., Carlton, W. and Ware, J. H. Effects of Dietary Antioxidant Supplementation on the Development of Malignant Lymphoma and Other…”
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Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism by Frederick, David W., Davis, James G., Dávila, Antonio, Agarwal, Beamon, Michan, Shaday, Puchowicz, Michelle A., Nakamaru-Ogiso, Eiko, Baur, Joseph A.

“…The NAD biosynthetic precursors nicotinamide mononucleotide and nicotinamide riboside are reported to confer resistance to metabolic defects induced by high…”
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854-P: ENT-03, a Centrally Acting Endogenous Spermine Bile Acid with PTP1B Inhibitory Activity, Has Potent Effects on Metabolism and Weight in a Mouse Model of Diet-Induced Obesity (DIO) by BARBUT, DENISE, BAUR, JOSEPH A., TITCHENELL, PAUL M., DAVIS, JAMES G., ZEMEL, MICHAEL B., ALEXANDER FLEMING, G., MOSES, ALAN C., ZASLOFF, MICHAEL

“…Background: We have discovered ENT-03, a spermine-bile acid of unprecedented structure in the brain of neonatal mice. ENT-03 appears postnatally at a time when…”
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NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury by Doke, Tomohito, Mukherjee, Sarmistha, Mukhi, Dhanunjay, Dhillon, Poonam, Abedini, Amin, Davis, James G., Chellappa, Karthikeyani, Chen, Beishan, Baur, Joseph A., Susztak, Katalin

“…Our understanding of how global changes in cellular metabolism contribute to human kidney disease remains incompletely understood. Here we show that…”
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Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium by Agarwal, Beamon, Campen, Matthew J, Channell, Meghan M, Wherry, Sarah J, Varamini, Behzad, Davis, James G, Baur, Joseph A, Smoliga, James M

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Rapamycin maintains NAD + /NADH redox homeostasis in muscle cells by Zhang, Zhigang, Xu, He N, Li, Siyu, Jr, Antonio Davila, Chellappa, Karthikeyani, Davis, James G, Guan, Yuxia, Frederick, David W, Chu, Weiqing, Zhao, Huaqing, Li, Lin Z, Baur, Joseph A

“…Rapamycin delays multiple age-related conditions and extends lifespan in organisms ranging from yeast to mice. However, the mechanisms by which rapamycin…”
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Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes by Xiong, Mengneng, Zhu, Zhiping, Tian, Suwen, Zhu, Ruping, Bai, Shun, Fu, Kaiqiang, Davis, James G., Sun, Zheng, Baur, Joseph A., Zheng, Ke, Ye, Lan

“…ABSTRACT Rapamycin is a clinically important drug that is used in transplantation and cancer therapy but which causes a number of side effects, including male…”
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Optical Redox Imaging of Fixed Unstained Muscle Slides Reveals Useful Biological Information by Xu, He N., Zhao, Huaqing, Chellappa, Karthikeyani, Davis, James G., Nioka, Shoko, Baur, Joseph A., Li, Lin Z.

“…Purpose Optical redox imaging (ORI) technique images cellular autofluorescence of nicotinamide adenine dinucleotide (NADH) and oxidized flavoproteins (Fp…”
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Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance by Ye, Lan, Widlund, Anne L, Sims, Carrie A, Lamming, Dudley W, Guan, Yuxia, Davis, James G, Sabatini, David M, Harrison, David E, Vang, Ole, Baur, Joseph A

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Fish otolith contains a unique structural protein, otolin‐1 by Murayama, Emi, Takagi, Yasuaki, Ohira, Tsuyoshi, Davis, James G., Greene, Mark I., Nagasawa, Hiromichi

“…A collagen‐like protein was identified from the otoliths of the chum salmon, Oncorhynchus keta. The otolith, composed mainly of calcium carbonate with small…”
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Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia by BOHNEN, Nicolaas I, KAUFER, Daniel I, HENDRICKSON, Rick, IVANCO, Larry S, LOPRESTI, Brian J, CONSTANTINE, Gregory M, MATHIS, Chester A, DAVIS, James G, MOORE, Robert Y, DEKOSKY, Steven T

“…We recently reported findings that loss of cortical acetylcholinesterase (AChE) activity is greater in parkinsonian dementia than in Alzheimer's disease (AD)…”
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