Search Results - "DAVIS, Elaine C"

Unraveling the mechanism of elastic fiber assembly: The roles of short fibulins by Yanagisawa, Hiromi, Davis, Elaine C.

“…Evolution of elastic fibers is associated with establishment of the closed circulation system. Primary roles of elastic fibers are to provide elasticity and…”
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Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma by Gerber, Elizabeth E., Gallo, Elena M., Fontana, Stefani C., Davis, Elaine C., Wigley, Fredrick M., Huso, David L., Dietz, Harry C.

“…Failure of integrin-mediated cell-matrix attachment is sufficient to initiate dermal fibrosis and autoimmunity in mouse models of scleroderma;…”
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Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans by Yamashiro, Yoshito, Thang, Bui Quoc, Shin, Seung Jae, Lino, Caroline Antunes, Nakamura, Tomoyuki, Kim, Jungsil, Sugiyama, Kaori, Tokunaga, Chiho, Sakamoto, Hiroaki, Osaka, Motoo, Davis, Elaine C, Wagenseil, Jessica E, Hiramatsu, Yuji, Yanagisawa, Hiromi

“…RATIONALE:Abnormal mechanosensing of smooth muscle cells (SMCs) resulting from the defective elastin-contractile units has been suggested to drive the…”
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Elastin Haploinsufficiency Impedes the Progression of Arterial Calcification in MGP‐Deficient Mice by Khavandgar, Zohreh, Roman, Hassem, Li, Jingjing, Lee, Sara, Vali, Hojatollah, Brinckmann, Juergen, Davis, Elaine C, Murshed, Monzur

“…ABSTRACT Matrix gla protein (MGP) is a potent inhibitor of extracellular matrix (ECM) mineralization. MGP‐deficiency in humans leads to Keutel syndrome, a rare…”
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Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation by van der Pluijm, Ingrid, Burger, Joyce, van Heijningen, Paula M, IJpma, Arne, van Vliet, Nicole, Milanese, Chiara, Schoonderwoerd, Kees, Sluiter, Willem, Ringuette, Lea-Jeanne, Dekkers, Dirk H W, Que, Ivo, Kaijzel, Erik L, te Riet, Luuk, MacFarlane, Elena G, Das, Devashish, van der Linden, Reinier, Vermeij, Marcel, Demmers, Jeroen A, Mastroberardino, Pier G, Davis, Elaine C, Yanagisawa, Hiromi, Dietz, Harry C, Kanaar, Roland, Essers, Jeroen

“…Abstract Aim Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To discover novel robust biomarkers, we aimed to better…”
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Autophagy and skeletal muscles in sepsis by Mofarrahi, Mahroo, Sigala, Ioanna, Guo, Yeting, Godin, Richard, Davis, Elaine C, Petrof, Basil, Sandri, Marco, Burelle, Yan, Hussain, Sabah N A

“…Mitochondrial injury develops in skeletal muscles during the course of severe sepsis. Autophagy is a protein and organelle recycling pathway which functions to…”
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Mutations in the Gene Encoding the RER Protein FKBP65 Cause Autosomal-Recessive Osteogenesis Imperfecta by Alanay, Yasemin, Avaygan, Hrispima, Camacho, Natalia, Utine, G. Eda, Boduroglu, Koray, Aktas, Dilek, Alikasifoglu, Mehmet, Tuncbilek, Ergul, Orhan, Diclehan, Bakar, Filiz Tiker, Zabel, Bernard, Superti-Furga, Andrea, Bruckner-Tuderman, Leena, Curry, Cindy J.R., Pyott, Shawna, Byers, Peter H., Eyre, David R., Baldridge, Dustin, Lee, Brendan, Merrill, Amy E., Davis, Elaine C., Cohn, Daniel H., Akarsu, Nurten, Krakow, Deborah

“…Osteogenesis imperfecta is a clinically and genetically heterogeneous brittle bone disorder that results from defects in the synthesis, structure, or…”
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Effect of glucose on the biomechanical function of arterial elastin by Wang, Yunjie, Zeinali-Davarani, Shahrokh, Davis, Elaine C., Zhang, Yanhang

“…Elastin is essential to provide elastic support for blood vessels. As a remarkably long-lived protein, elastin can suffer from cumulative effects of exposure…”
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Angiopoietin-1 enhances skeletal muscle regeneration in mice by Mofarrahi, Mahroo, McClung, Joseph M, Kontos, Christopher D, Davis, Elaine C, Tappuni, Bassman, Moroz, Nicolay, Pickett, Amy E, Huck, Laurent, Harel, Sharon, Danialou, Gawiyou, Hussain, Sabah N A

“…Activation of muscle progenitor cell myogenesis and endothelial cell angiogenesis is critical for the recovery of skeletal muscle from injury. Angiopoietin-1…”
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Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice by Yamashiro, Yoshito, Papke, Christina L, Kim, Jungsil, Ringuette, Lea-Jeanne, Zhang, Qing-Jun, Liu, Zhi-Ping, Mirzaei, Hamid, Wagenseil, Jessica E, Davis, Elaine C, Yanagisawa, Hiromi

“…Smooth muscle cells (SMCs) and the extracellular matrix (ECM) are intimately associated in the aortic wall. Fbln4(SMKO) mice with an SMC-specific deletion of…”
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Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells by Chan, Wilson, Ismail, Hodan, Mayaki, Dominique, Sanchez, Veronica, Tiedemann, Kerstin, Davis, Elaine C, Hussain, Sabah N A

“…Fibulin-5 is an extracellular matrix glycoprotein that plays critical roles in vasculogenesis and embryonic development. Deletion of Fibulin-5 in mice results…”
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Mutations in LTBP4 Cause a Syndrome of Impaired Pulmonary, Gastrointestinal, Genitourinary, Musculoskeletal, and Dermal Development by Urban, Zsolt, Hucthagowder, Vishwanathan, Schürmann, Nura, Todorovic, Vesna, Zilberberg, Lior, Choi, Jiwon, Sens, Carla, Brown, Chester W., Clark, Robin D., Holland, Kristen E., Marble, Michael, Sakai, Lynn Y., Dabovic, Branka, Rifkin, Daniel B., Davis, Elaine C.

“…We report recessive mutations in the gene for the latent transforming growth factor-β binding protein 4 (LTBP4) in four unrelated patients with a human…”
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Autophagic flux and oxidative capacity of skeletal muscles during acute starvation by Mofarrahi, Mahroo, Guo, Yeting, Haspel, Jeffrey A, Choi, Augustine MK, Davis, Elaine C, Gouspillou, Gilles, Hepple, Russell T, Godin, Richard, Burelle, Yan, Hussain, Sabah NA

“…Autophagy is an important proteolytic pathway in skeletal muscles. The roles of muscle fiber type composition and oxidative capacity remain unknown in relation…”
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Discrete Contributions of Elastic Fiber Components to Arterial Development and Mechanical Compliance by Carta, Luca, Wagenseil, Jessica E, Knutsen, Russell H, Mariko, Boubacar, Faury, Gilles, Davis, Elaine C, Starcher, Barry, Mecham, Robert P, Ramirez, Francesco

“…OBJECTIVE—Even though elastin and fibrillin-1 are the major structural components of elastic fibers, mutations in elastin and fibrillin-1 lead to narrowing of…”
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Fibulin-2 and Fibulin-5 Cooperatively Function to Form the Internal Elastic Lamina and Protect From Vascular Injury by Chapman, Shelby L, Sicot, F -X, Davis, Elaine C, Huang, Jianbin, Sasaki, Takako, Chu, Mon-Li, Yanagisawa, Hiromi

“…OBJECTIVE—Recent findings on the role of fibulin-5 (Fbln5) have provided substantial progress in understanding the molecular mechanism of elastic fiber…”
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Fibrillin-1 Interactions with Fibulins Depend on the First Hybrid Domain and Provide an Adaptor Function to Tropoelastin by El-Hallous, Ehab, Sasaki, Takako, Hubmacher, Dirk, Getie, Melkamu, Tiedemann, Kerstin, Brinckmann, Jürgen, Bätge, Boris, Davis, Elaine C., Reinhardt, Dieter P.

“…Fibrillin-containing microfibrils in elastic and nonelastic extracellular matrices play important structural and functional roles in various tissues, including…”
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Failure of Pelvic Organ Support in Mice Deficient In Fibulin-3 by Rahn, David D, Acevedo, Jesús F, Roshanravan, Shayzreen, Keller, Patrick W, Davis, Elaine C, Marmorstein, Lihua Y, Word, R. Ann

“…Fibulin-5 is crucial for normal elastic fiber synthesis in the vaginal wall; more than 90% of fibulin-5-knockout mice develop pelvic organ prolapse by 20 weeks…”
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Fibrillins, Fibulins, and Matrix-Associated Glycoprotein Modulate the Kinetics and Morphology of in Vitro Self-Assembly of a Recombinant Elastin-like Polypeptide by Cirulis, Judith T, Bellingham, Catherine M, Davis, Elaine C, Hubmacher, Dirk, Reinhardt, Dieter P, Mecham, Robert P, Keeley, Fred W

“…Elastin is the polymeric protein responsible for the properties of extensibility and elastic recoil of the extracellular matrix in a variety of tissues…”
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Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters by Kozel, Beth A., Rongish, Brenda J., Czirok, Andras, Zach, Julia, Little, Charles D., Davis, Elaine C., Knutsen, Russell H., Wagenseil, Jessica E., Levy, Marilyn A., Mecham, Robert P.

“…To study the dynamics of elastic fiber assembly, mammalian cells were transfected with a cDNA construct encoding bovine tropoelastin in frame with the Timer…”
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Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly by Choi, Jiwon, Bergdahl, Andreas, Zheng, Qian, Starcher, Barry, Yanagisawa, Hiromi, Davis, Elaine C.

“…Fibulin-5 is a 66 kDa modular, extracellular matrix protein that localizes to elastic fibers. Although in vitro protein–protein binding studies have shown that…”
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