Search Results - "DAVIS, DARRYL"

Cardiac stem cells in the post-Anversa era by Davis, Darryl R

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Cell therapy for patients with Duchenne muscular dystrophy by Davis, Darryl R

“…For unclear reasons, the myopathy associated with Duchenne muscular dystrophy begins in the proximal lower limbs before spreading to affect the upper…”
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RNA and the emerging potential of bio-inspired molecules in cardiovascular disease therapies by Ahmed, Noreen, Davis, Darryl R

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State‐of‐play for cellular therapies in cardiac repair and regeneration by Vaka, Ramana, Davis, Darryl R.

“…Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease…”
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Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction by Cheng, Ke, Li, Tao-Sheng, Malliaras, Konstantinos, Davis, Darryl R, Zhang, Yiqiang, Marbán, Eduardo

“…RATIONALE:The success of cardiac stem cell therapies is limited by low cell retention, due at least in part to washout via coronary veins. OBJECTIVE:We sought…”
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Systematic review of pre-clinical therapies for post-operative atrial fibrillation by Seo, Chanhee, Michie, Connor, Hibbert, Benjamin, Davis, Darryl R

“…Post-operative atrial fibrillation (POAF) is a frequent cardiothoracic surgery complication that increases hospital stay, mortality and costs. Despite decades…”
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Concise Review: Heart‐Derived Cell Therapy 2.0: Paracrine Strategies to Increase Therapeutic Repair of Injured Myocardium by Rafatian, Ghazaleh, Davis, Darryl R.

“…Despite progress in cardiovascular medicine, the incidence of heart failure is rising and represents a growing challenge. To address this, ex vivo proliferated…”
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Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue by Davis, Darryl R, Zhang, Yiqiang, Smith, Rachel R, Cheng, Ke, Terrovitis, John, Malliaras, Konstantinos, Li, Tao-Sheng, White, Anthony, Makkar, Raj, Marbán, Eduardo

“…At least four laboratories have shown that endogenous cardiac progenitor cells (CPCs) can be grown directly from adult heart tissue in primary culture, as…”
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Paracrine Heart Repair Comes of Age by Davis, Darryl R.

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Nanoengineered Electroconductive Collagen-Based Cardiac Patch for Infarcted Myocardium Repair by Hosoyama, Katsuhiro, Ahumada, Manuel, McTiernan, Christopher D, Davis, Darryl R, Variola, Fabio, Ruel, Marc, Liang, Wenbin, Suuronen, Erik J, Alarcon, Emilio I

“…We have prepared and tested in vivo a novel nanoengineered hybrid electroconductive cardiac patch for treating the infarcted myocardium. Of the prepared and…”
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Cellular mechanisms underlying cardiac engraftment of stem cells by Kanda, Pushpinder, Davis, Darryl R

“…Over the past decade, it has become clear that long-term engraftment of any ex vivo expanded cell product transplanted into injured myocardium is modest and…”
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DMP_MI: An Effective Diabetes Mellitus Classification Algorithm on Imbalanced Data With Missing Values by Wang, Qian, Cao, Weijia, Guo, Jiawei, Ren, Jiadong, Cheng, Yongqiang, Davis, Darryl N.

“…As a widely known chronic disease, diabetes mellitus is called a silent killer. It makes the body produce less insulin and causes increased blood sugar, which…”
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Combinatorial Effect of Biomaterials and Extracellular Vesicle Therapy for Heart Failure with Reduced Ejection Fraction: A Systematic Review of Preclinical Studies by Malhotra, Kamal, Van Remortel, Sophie, Ly, Valentina, Davis, Darryl R.

“…Heart failure, a pervasive global health burden, necessitates innovative therapeutic strategies. Extracellular vesicles (EVs) have emerged as promising…”
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Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection by Vigneault, Patrick, Parent, Sandrine, Kanda, Pushpinder, Michie, Connor, Davis, Darryl R., Nattel, Stanley

“…We have shown that calcium-activated potassium (KCa)-channels regulate fundamental progenitor-cell functions, including proliferation, but their contribution…”
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Calcium‐dependent potassium channels control proliferation of cardiac progenitor cells and bone marrow‐derived mesenchymal stem cells by Vigneault, Patrick, Naud, Patrice, Qi, Xiaoyan, Xiao, Jiening, Villeneuve, Louis, Davis, Darryl R., Nattel, Stanley

“…Key points Ex vivo proliferated c‐Kit+ endogenous cardiac progenitor cells (eCPCs) obtained from mouse and human cardiac tissues have been reported to express…”
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Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice by McLaughlin, Sarah, Sedlakova, Veronika, Zhang, Qingzhou, McNeill, Brian, Smyth, David, Seymour, Richard, Davis, Darryl R., Ruel, Marc, Brand, Marjorie, Alarcon, Emilio I., Suuronen, Erik J.

“…Methylglyoxal (MG) production after myocardial infarction (MI) leads to advanced glycation end‐product formation, adverse remodeling, and loss of cardiac…”
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Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways by Vaka, Ramana, Parent, Sandrine, Risha, Yousef, Khan, Saad, Courtman, David, Stewart, Duncan J., Davis, Darryl R.

“…The cell origin-specific payloads within extracellular vesicles (EVs) mediate therapeutic bioactivity for a wide variety of stem cell types. In this study, we…”
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Electrical effects of stem cell transplantation for ischaemic cardiomyopathy: friend or foe? by Mount, Seth, Davis, Darryl R.

“…Despite advances in other realms of cardiac care, the mortality attributable to ischaemic cardiomyopathy has only marginally decreased over the last 10 years…”
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Systematic review of biological therapies for atrial fibrillation by McRae, Callum, Kapoor, Anshul, Kanda, Pushpinder, Hibbert, Benjamin, Davis, Darryl R.

“…Biological therapies that increase or suppress the expression of transcripts underlying atrial fibrillation (AF) progression are increasingly being explored to…”
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Mechanisms of Cardiac Repair in Cell Therapy by Collet, Bérénice C, Davis, Darryl R

“…Heart failure is an important cause of morbidity and mortality. More than 20 years ago, special interest was drawn to cell therapy as a means of restoring…”
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