Search Results - "DAVIES, Nicholas J"

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks by Higgs, Martin R., Reynolds, John J., Winczura, Alicja, Blackford, Andrew N., Borel, Valérie, Miller, Edward S., Zlatanou, Anastasia, Nieminuszczy, Jadwiga, Ryan, Ellis L., Davies, Nicholas J., Stankovic, Tatjana, Boulton, Simon J., Niedzwiedz, Wojciech, Stewart, Grant S.

“…Recognition and repair of damaged replication forks are essential to maintain genome stability and are coordinated by the combined action of the Fanconi anemia…”
Get full text

TGFβ1 priming enhances CXCR3‐mediated mesenchymal stromal cell engraftment to the liver and enhances anti‐inflammatory efficacy by Garg, Abhilok, Khan, Sheeba, Luu, N., Nicholas, Davies J., Day, Victoria, King, Andrew L., Fear, Janine, Lalor, Patricia F., Newsome, Philip N.

“…The immunomodulatory characteristics of mesenchymal stromal cells (MSC) confers them with potential therapeutic value in the treatment of…”
Get full text

Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts by Davies, Nicholas J, Kwok, Marwan, Gould, Clive, Oldreive, Ceri E, Mao, Jingwen, Parry, Helen, Smith, Edward, Agathanggelou, Angelo, Pratt, Guy, Taylor, Alexander Malcolm R, Moss, Paul, Griffiths, Mike, Stankovic, Tatjana

“…Subclonal heterogeneity and clonal selection influences disease progression in chronic lymphocytic leukemia (CLL). It is therefore important that therapeutic…”
Get full text

Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia by Khanim, Farhat L, Hayden, Rachel E, Birtwistle, Jane, Lodi, Alessia, Tiziani, Stefano, Davies, Nicholas J, Ride, Jon P, Viant, Mark R, Gunther, Ulrich L, Mountford, Joanne C, Schrewe, Heinrich, Green, Richard M, Murray, Jim A, Drayson, Mark T, Bunce, Chris M

“…The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also…”
Get full text

Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

“…Over recent years, enzymes of the aldo-keto reductase (AKR) 1C subfamily have been implicated in the progression of prostate, breast, endometrial and leukemic…”
Get full text

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants by Agathanggelou, Angelo, Weston, Victoria J, Perry, Tracey, Davies, Nicholas J, Skowronska, Anna, Payne, Daniel T, Fossey, John S, Oldreive, Ceri E, Wei, Wenbin, Pratt, Guy, Parry, Helen, Oscier, David, Coles, Steve J, Hole, Paul S, Darley, Richard L, McMahon, Michael, Hayes, John D, Moss, Paul, Stewart, Grant S, Taylor, A Malcolm R, Stankovic, Tatjana

“…Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses…”
Get full text

T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice by Oldreive, Ceri E, Skowronska, Anna, Davies, Nicholas J, Parry, Helen, Agathanggelou, Angelo, Krysov, Sergey, Packham, Graham, Rudzki, Zbigniew, Cronin, Laura, Vrzalikova, Katerina, Murray, Paul, Odintsova, Elena, Pratt, Guy, Taylor, A Malcolm R, Moss, Paul, Stankovic, Tatjana

“…Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised…”
Get full text

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status by Agathanggelou, Angelo, Smith, Edward, Davies, Nicholas J., Kwok, Marwan, Zlatanou, Anastasia, Oldreive, Ceri E., Mao, Jingwen, Da Costa, David, Yadollahi, Sina, Perry, Tracey, Kearns, Pamela, Skowronska, Anna, Yates, Elliot, Parry, Helen, Hillmen, Peter, Reverdy, Celine, Delansorne, Remi, Paneesha, Shankara, Pratt, Guy, Moss, Paul, Taylor, A.Malcolm R., Stewart, Grant S., Stankovic, Tatjana

“…The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established…”
Get full text

TGFβ 1 priming enhances CXCR3-mediated mesenchymal stromal cell engraftment to the liver and enhances anti-inflammatory efficacy by Garg, Abhilok, Khan, Sheeba, Luu, N, Nicholas, Davies J, Day, Victoria, King, Andrew L, Fear, Janine, Lalor, Patricia F, Newsome, Philip N

“…The immunomodulatory characteristics of mesenchymal stromal cells (MSC) confers them with potential therapeutic value in the treatment of…”
Get full text

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL by Kwok, Marwan, Oldreive, Ceri, Rawstron, Andy C., Goel, Anshita, Papatzikas, Grigorios, Jones, Rhiannon E., Drennan, Samantha, Agathanggelou, Angelo, Sharma-Oates, Archana, Evans, Paul, Smith, Edward, Dalal, Surita, Mao, Jingwen, Hollows, Robert, Gordon, Naheema, Hamada, Mayumi, Davies, Nicholas J., Parry, Helen, Beggs, Andrew D., Munir, Talha, Moreton, Paul, Paneesha, Shankara, Pratt, Guy, Taylor, A. Malcolm R., Forconi, Francesco, Baird, Duncan M., Cazier, Jean-Baptiste, Moss, Paul, Hillmen, Peter, Stankovic, Tatjana

“…Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed…”
Get full text

AKR1C Isoforms Represent a Novel Cellular Target for Jasmonates alongside Their Mitochondrial-Mediated Effects by DAVIES, Nicholas J, HAYDEN, Rachel E, SIMPSON, Paul J, BIRTWISTLE, Jane, MAYER, Katarina, RIDE, Jonathan P, BUNCE, Chris M

“…Members of the aldo-keto reductase (AKR) superfamily, particularly the AKR1C subfamily, are emerging as important mediators of the pathology of cancer. Agents…”
Get full text

Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein by Marsh, Elizabeth K, Delury, Craig P, Davies, Nicholas J, Weston, Christopher J, Miah, Mohammed A L, Banks, Lawrence, Parish, Joanna L, Higgs, Martin R, Roberts, Sally

“…The function of a conserved PDS95/DLG1/ZO1 (PDZ) binding motif (E6 PBM) at the C-termini of E6 oncoproteins of high-risk human papillomavirus (HPV) types…”
Get full text

Developing Recreational Trails: Motivations for Recreational Walking by Davies, Nicholas J., Lumsdon, Leslie M., Weston, Richard

“…This paper seeks to explore the motivations and preferences of recreational walkers in near-urban areas and the implications for trail development. A…”
Get full text

The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis by Birtwistle, Jane, Hayden, Rachel E, Khanim, Farhat L, Green, Richard M, Pearce, Claire, Davies, Nicholas J, Wake, Naomi, Schrewe, Heiner, Ride, Jonathan P, Chipman, James K, Bunce, Chris M

“…The aldo-keto reductase AKR1C3, has been shown to regulate myelopoiesis via its ability to metabolise prostaglandin D2 (PGD2). Other studies have demonstrated…”
Get more information

Erratum to: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

Get full text

Correction: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

Get full text

Making sense of molecular signatures in the immune system by Davies, Nicholas J, Tadesse, Mahlet G T, Vannucci, Marina, Kikuchi, Hugh, Trevino, Victor, Sarti, Donatella, Dragoni, Ilaria, Contestabile, Andrea, Zanders, Edward, Falciani, Francesco

“…The development of Functional Genomics technologies has opened new avenues to investigate the complexity of the immune system. Microarray technology has been…”
Get more information

A New Murine Model for B Cell Malignancies on ATM-Deficient Background Reveals Involvement of Multiple Pathogenic Mechanisms by Francis, Tegan A, Davies, Nicholas J, Griffiths, Michael John, Agathanggelou, Angelo, Ibrahim, Maha, Murray, Paul G., Rudzki, Zbigniew, Stankovic, Tatjana, Taylor, Alexander M R

“…Inactivation of Ataxia Telangiectasia Mutated (ATM) gene, a principal regulator of DNA damage responses, is a frequent event in a wide range of sporadic B and…”
Get full text

Targeted Treatments: Pre-Clinical Evaluation Of Efficacy By Tracking Clonal Diversity In CLL Xenograft Models by Davies, Nicholas J, Oldreive, Ceri E, Agathanggelou, Angelo, Gould, Clive, Pratt, Guy, Griffiths, Mike, Stankovic, Tatjana

“…Progressive CLL with DNA damage response defects caused by ATM or TP53 inactivation is still a therapeutic problem. There is currently a growing appreciation…”
Get full text

London Weighting Allowance by Davies, Nicholas J. H.

Get full text