Search Results - "DAVIES, Carwyn"

Histopathological and Immunological Findings in the Common Marmoset Following Exposure to Aerosolized SARS-CoV-2 by Ireland, Rachel E., Davies, Carwyn D., Keyser, Emma, Findlay, James S. F., Eastaugh, Lin, Laws, Thomas R., Salguero, Francisco J., Hunter, Laura, Nelson, Michelle

“…There is an enduring requirement to develop animal models of COVID-19 to assess the efficacy of vaccines and therapeutics that can be used to treat the disease…”
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Efficacy of finafloxacin in a murine model of inhalational glanders by Barnes, Kay B, Bayliss, Marc, Davies, Carwyn, Richards, Mark I, Laws, Thomas R, Vente, Andreas, Harding, Sarah V

“…, the causative agent of glanders, is principally a disease of equines, although it can also infect humans and is categorized by the U.S. Centers for Disease…”
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An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia by Wren, Brendan W., Prior, Joann L., Atkins, Timothy P., Denman, Carmen, Moule, Madeleine G., Jenner, Dominic C., Whelan, Adam O., Davies, Carwyn H., Nelson, M., Marshall, Laura E., Cuccui, Jon

“…There is a requirement for an efficacious vaccine to protect people against infection from Francisella tularensis, the etiological agent of tularemia. The…”
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Aerosol infection of Balb/c mice with eastern equine encephalitis virus; susceptibility and lethality by Phelps, Amanda L, O'Brien, Lyn M, Eastaugh, Lin S, Davies, Carwyn, Lever, Mark S, Ennis, Jane, Zeitlin, Larry, Nunez, Alejandro, Ulaeto, David O

“…Eastern equine encephalitis virus is an alphavirus that naturally cycles between mosquitoes and birds or rodents in Eastern States of the US. Equine infection…”
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Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics by Fernandez-Mercado, Marta, Yip, Bon Ham, Pellagatti, Andrea, Davies, Carwyn, Larrayoz, María José, Kondo, Toshinori, Pérez, Cristina, Killick, Sally, McDonald, Emma-Jane, Odero, María Dolores, Agirre, Xabier, Prósper, Felipe, Calasanz, María José, Wainscoat, James S, Boultwood, Jacqueline

“…Acute myeloid leukemia patients with normal cytogenetics (CN-AML) account for almost half of AML cases. We aimed to study the frequency and relationship of a…”
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Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition by Bachmann, Petra S., Piazza, Rocco G., Janes, Mary E., Wong, Nicholas C., Davies, Carwyn, Mogavero, Angela, Bhadri, Vivek A., Szymanska, Barbara, Geninson, Greta, Magistroni, Vera, Cazzaniga, Giovanni, Biondi, Andrea, Miranda-Saavedra, Diego, Göttgens, Berthold, Saffery, Richard, Craig, Jeffrey M., Marshall, Glenn M., Gambacorti-Passerini, Carlo, Pimanda, John E., Lock, Richard B.

“…Glucocorticoids play a critical role in the therapy of lymphoid malignancies, including pediatric acute lymphoblastic leukemia (ALL), although the mechanisms…”
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The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei by Nelson, Michelle, Barnes, Kay B, Davies, Carwyn H, Cote, Christopher K, Meinig, J Matthew, Biryukov, Sergei S, Dyer, David N, Frick, Ondraya, Heine, Henry, Pfefferle, Denise A, Horstman-Smith, Amanda, Barbaras, Julie, Harding, Sarah V

“…, the causative agent of the disease melioidosis, has been isolated from the environment in 45 countries. The treatment of melioidosis is complex, requiring…”
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Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34+ progenitor cells by Davies, Carwyn, Yip, Bon Ham, Fernandez‐Mercado, Marta, Woll, Petter S., Agirre, Xabier, Prosper, Felipe, Jacobsen, Sten E., Wainscoat, James S., Pellagatti, Andrea, Boultwood, Jacqueline

“…Summary The ASXL1 gene encodes a chromatin‐binding protein involved in epigenetic regulation in haematopoietic cells. Loss‐of‐function ASXL1 mutations occur in…”
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Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders by Barnes, Kay B, Steward, Jackie, Thwaite, Joanne E, Lever, M. Stephen, Davies, Carwyn H, Armstrong, Stuart J, Laws, Thomas R, Roughley, Neil, Harding, Sarah V, Atkins, Timothy P, Simpson, Andrew J.H, Atkins, Helen S

“…Abstract Burkholderia pseudomallei is the causative agent of the disease melioidosis, which is prevalent in tropical countries and is intractable to a number…”
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Development and Characterization of Mouse Models of Infection with Aerosolized Brucella melitensis and Brucella suis by Smither, Sophie J, Perkins, Stuart D, Davies, Carwyn, Stagg, Anthony J, Nelson, Michelle, Atkins, Helen S

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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ASSESSMENT OF ARGININE 97 AND LYSINE 72 AS DETERMINANTS OF SUBSTRATE SPECIFICITY IN CYTOCHROME P450 2C9 (CYP2C9) by DAVIES, Carwyn, WITHAM, Katey, SCOTT, Justin R, PEARSON, Andrew, DEVOSS, James J, GRAHAM, Sandra E, GILLAM, Elizabeth M. J

“…CYP2C9 is distinguished by a preference for substrates bearing a negative charge at physiological pH. Previous studies have suggested that CYP2C9 residues R97…”
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The UK biological-warfare program: dual-use contributions to the field of aerobiology by Beedham, Richard J., Davies, Carwyn H.

“…Between 1940 and the late 1950s, the United Kingdom had a limited biological program to provide a retaliatory capability should UK forces be attacked using…”
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Comparison of Experimental Middle East Respiratory Syndrome Coronavirus Infection Acquired by Three Individual Routes of Infection in the Common Marmoset by Nelson, Michelle, O'Brien, Lyn M, Davies, Carwyn, Keyser, Emma, Butcher, Wendy, Smither, Sophie J, Nunez, Alejandro, Salguero, F Javier, Lever, M Stephen

“…Two strains of Middle East respiratory syndrome coronavirus (MERS-CoV), England 1 and Erasmus Medical Centre/2012 (EMC/2012), were used to challenge common…”
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p21 WAF1 modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia by Davies, Carwyn, Hogarth, Linda A, Mackenzie, Karen L, Hall, Andrew G, Lock, Richard B

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Comparison of the Pharmacokinetics of RIPK1 Inhibitor GSK2982772 in Healthy Western and Japanese Subjects by Tompson, Debra J., Davies, Carwyn, Scott, Nicola E., Cannons, Edward P., Kostapanos, Michalis, Gross, Annette S., Powell, Marcy, Ino, Hiroko, Shimamura, Ryutaro, Ogura, Hirofumi, Nagakubo, Takashi, Igarashi, Harue, Nakano, Atsushi

“…Background and Objectives GSK2982772 is an oral small-molecule RIPK1 inhibitor with potential therapeutic efficacy in immune-mediated inflammatory diseases…”
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Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague by Hamblin, Karleigh A, Armstrong, Stuart J, Barnes, Kay B, Davies, Carwyn, Laws, Thomas, Blanchard, James D, Harding, Sarah V, Atkins, Helen S

“…Inhalation of can lead to pneumonic plague, which without treatment is inevitably fatal. Two novel formulations of liposome-encapsulated ciprofloxacin,…”
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p21WAF1 modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia by Davies, Carwyn, Hogarth, Linda A, Mackenzie, Karen L, Hall, Andrew G, Lock, Richard B

“…p21 WAF1 is a well-characterized mediator of cell cycle arrest and may also modulate chemotherapy-induced cell death. The role of p21 WAF1 in drug-induced cell…”
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p53-independent Epigenetic Repression of the p21WAF1 Gene in T-cell Acute Lymphoblastic Leukemia by Davies, Carwyn, Hogarth, Linda A., Dietrich, Philipp A., Bachmann, Petra S., Mackenzie, Karen L., Hall, Andrew G., Lock, Richard B.

“…The p53 protein is a primary mediator of cellular apoptosis and growth arrest after exposure to DNA-damaging agents. Previous work has shown that the majority…”
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The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized IBurkholderia pseudomallei/I by Nelson, Michelle, Barnes, Kay B, Davies, Carwyn H, Cote, Christopher K, Meinig, J. Matthew, Biryukov, Sergei S, Dyer, David N, Frick, Ondraya, Heine, Henry, Pfefferle, Denise A, Horstman-Smith, Amanda, Barbaras, Julie, Harding, Sarah V

“…Burkholderia pseudomallei, the causative agent of the disease melioidosis, has been isolated from the environment in 45 countries. The treatment of melioidosis…”
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Liposome Encapsulation of Ciprofloxacin Improves Protection against Highly Virulent Francisella tularensis Strain Schu S4 by HAMBLIN, Karleigh A, ARMSTRONG, Stuart J, BARNES, Kay B, DAVIES, Carwyn, WONG, Jonathan P, BLANCHARD, James D, HARDING, Sarah V, SIMPSON, Andrew J. H, ATKINS, Helen S

“…Liposome-encapsulated ciprofloxacin for inhalation (CFI) was investigated as a putative postexposure therapeutic for two strains of Francisella tularensis. The…”
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