Search Results - "DAVIDSON, JAMES P."

First Enantiospecific Total Synthesis of the Antitubercular Marine Natural Product Pseudopteroxazole. Revision of Assigned Stereochemistry by Davidson, James P, Corey, E. J

“…A concise, enantiospecific synthesis of pseudopteroxazole (3), which had originally been assigned structure 1, has been accomplished starting from…”
Get full text

Calorimetric and Structural Studies of 1,2,3-Trisubstituted Cyclopropanes as Conformationally Constrained Peptide Inhibitors of Src SH2 Domain Binding by Davidson, James P, Lubman, Olga, Rose, Thierry, Waksman, Gabriel, Martin, Stephen F

“…Isothermal titration calorimetry and X-ray crystallography have been used to determine the structural and thermodynamic consequences associated with…”
Get full text

Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties by Sweeney, Zachary K., Kennedy-Smith, Joshua J., Wu, Jeffrey, Arora, Nidhi, Billedeau, J. Roland, Davidson, James P., Fretland, Jennifer, Hang, Julie Q., Heilek, Gabrielle M., Harris, Seth F., Hirschfeld, Donald, Inbar, Petra, Javanbakht, Hassan, Jernelius, Jesper A., Jin, Qingwu, Li, Yu, Liang, Weiling, Roetz, Ralf, Sarma, Keshab, Smith, Mark, Stefanidis, Dimitrio, Su, Guoping, Suh, Judy M., Villaseñor, Armando G., Welch, Michael, Zhang, Fang-Jie, Klumpp, Klaus

“…Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) are part of the preferred treatment regimens for individuals infected with HIV. These NNRTI‐based…”
Get full text

An Evaluation of the Pharmacodynamics, Safety, and Tolerability of the Potassium Binder RDX7675 by Pitt, Bertram, Zann, Vanessa, Roe, Chris, Jacobs, Jeffrey W., Davidson, James P., Dowd, Christine, Kumaraswamy, Padmapriya, Lin, Fangling, Korner, Paul, Blanks, Robert C., Rosenbaum, David P.

“…Hyperkalemia is common in patients with heart failure or chronic kidney disease, particularly those taking renin‐angiotensin‐aldosterone system inhibitors, and…”
Get full text

Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice by Davidson, James P, King, Andrew J, Kumaraswamy, Padmapriya, Caldwell, Jeremy S, Korner, Paul, Blanks, Robert C, Jacobs, Jeffrey W

“…Hyperkalemia is a common complication in patients with heart failure or chronic kidney disease, particularly those who are taking inhibitors of the…”
Get more information

Development of a Scalable Synthesis of a Bruton’s Tyrosine Kinase Inhibitor via C–N and C–C Bond Couplings as an End Game Strategy by Hong, Jun-Bae, Davidson, James P, Jin, Qingwu, Lee, Gary R, Matchett, Michael, O’Brien, Erin, Welch, Michael, Bingenheimer, Bill, Sarma, Keshab

“…A scalable and convergent synthesis of a BTK (Bruton’s tyrosine kinase) inhibitor has been developed. Synthetic routes to key intermediates were explored for…”
Get full text

Design of Annulated Pyrazoles as Inhibitors of HIV-1 Reverse Transcriptase by Sweeney, Zachary K, Harris, Seth F, Arora, Nidhi, Javanbakht, Hassan, Li, Yu, Fretland, Jennifer, Davidson, James P, Billedeau, J. Roland, Gleason, Shelley K, Hirschfeld, Donald, Kennedy-Smith, Joshua J, Mirzadegan, Taraneh, Roetz, Ralf, Smith, Mark, Sperry, Sarah, Suh, Judy M, Wu, Jeffrey, Tsing, Stan, Villaseñor, Armando G, Paul, Amber, Su, Guoping, Heilek, Gabrielle, Hang, Julie Q, Zhou, Amy S, Jernelius, Jesper A, Zhang, Fang-Jie, Klumpp, Klaus

“…Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are recommended components of preferred combination antiretroviral therapies used for the treatment of…”
Get full text

Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate by Zann, Vanessa, McDermott, John, Jacobs, Jeffrey W, Davidson, James P, Lin, Fangling, Korner, Paul, Blanks, Robert C, Rosenbaum, David P

“…Hyperkalemia is a potentially life-threatening condition that patients with heart failure or chronic kidney disease, especially those taking…”
Get full text

Facile Unmasking of Dicobalt Hexacarbonyl Complexes of 1-Cyclodecene-3,9-diynes (Enediynes) by Jones, Graham B, Wright, Justin M, Rush, Teresa M, Plourde, Gary W, Kelton, Thomas F, Mathews, Jude E, Huber, Robert S, Davidson, James P

Get full text

A Synthesis of 3,5-Disubstituted Phenols by Davidson, James P, Sarma, Keshab, Fishlock, Dan, Welch, Michael H, Sukhtankar, Sunil, Lee, Gary M, Martin, Michael, Cooper, Gary F

“…Robust and scalable syntheses of some synthetically useful 3,5-disubstituted phenols are presented. The process involves the selective displacement of a…”
Get full text

Abstract 14911: RDX227675, the Calcium Salt of a Novel Polystyrene Sulfonate-Based Resin, Reduces Potassium Absorption in Healthy Volunteers by Zann, Vanessa, Roe, Chris, Jacobs, Jeffrey W, Davidson, James P, Blanks, Robert C, Rosenbaum, David P

“…IntroductionPatients with heart failure or chronic kidney disease, especially those taking RAAS inhibitors, are at high risk of developing hyperkalemia, which…”
Get full text

Cyclopropane-Derived Peptidomimetics. Design, Synthesis, and Evaluation of Novel Ras Farnesyltransferase Inhibitors by Hillier, Michael C., Davidson, James P., Martin, Stephen F.

“…Trisubstituted cyclopropanes have previously been established as rigid replacements of dipeptide arrays in several biological systems. Toward further…”
Get full text

Use of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide mimics in SH2 antagonists by Davidson, James P, Martin, Stephen F

“…Novel conformationally constrained phosphotyrosine pseudopeptide derivatives of the tetrapeptide pY-E-E-I were prepared and evaluated as SH2 binding…”
Get full text

Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties (ChemMedChem 1/2009) by Sweeney, Zachary K, Kennedy-Smith, Joshua J, Wu, Jeffrey, Arora, Nidhi, Billedeau, J Roland, Davidson, James P, Fretland, Jennifer, Hang, Julie Q, Heilek, Gabrielle M, Harris, Seth F, Hirschfeld, Donald, Inbar, Petra, Javanbakht, Hassan, Jernelius, Jesper A, Jin, Qingwu, Li, Yu, Liang, Weiling, Roetz, Ralf, Sarma, Keshab, Smith, Mark, Stefanidis, Dimitrio, Su, Guoping, Suh, Judy M, Villasenor, Armando G, Welch, Michael, Zhang, Fang-Jie, Klumpp, Klaus

“…The cover picture shows a cut-away view of a diaryl ether non-nucleoside reverse transcriptase inhibitor (cyan) bound to HIV reverse transcriptase. The cartoon…”
Get full text

Cover Picture: Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties (ChemMedChem 1/2009) by Sweeney, Zachary K., Kennedy-Smith, Joshua J., Wu, Jeffrey, Arora, Nidhi, Billedeau, J. Roland, Davidson, James P., Fretland, Jennifer, Hang, Julie Q., Heilek, Gabrielle M., Harris, Seth F., Hirschfeld, Donald, Inbar, Petra, Javanbakht, Hassan, Jernelius, Jesper A., Jin, Qingwu, Li, Yu, Liang, Weiling, Roetz, Ralf, Sarma, Keshab, Smith, Mark, Stefanidis, Dimitrio, Su, Guoping, Suh, Judy M., Villaseñor, Armando G., Welch, Michael, Zhang, Fang-Jie, Klumpp, Klaus

Get full text

Synthesis of simplified analogues of eleutherobin via a Claisen rearrangement/RCM strategy by Frankie Mak, S.Y., Chiang, Gary C.H., Davidson, James E.P., Davies, John E., Ayscough, Andrew, Pain, Gilles, Burton, Jonathan W., Holmes, Andrew B.

Get full text

Cyclopropane-Derived Peptidomimetics. Design, Synthesis, and Evaluation of Novel Ras Farnesyltransferase Inhibitors by HILLIER, Michael C., DAVIDSON, James P., MARTIN, Stephen F.

Get full text

HEART FAILURE ASSOCIATED WITH UNUSUAL HEPATIC INCLUSIONS IN A DECKERT'S RAT SNAKE1 by JACOBSON, ELLIOTT R., SEELY, JOHN C., NOVILLA, MELITON N., DAVIDSON, JAMES P.

“…A juvenile Deckert's rat snake, Elaphe obsoleta deckerti, was presented with a circumferential enlargement of the body in the region of the heart. The heart…”
Get full text

METASTATIC, PAPILLARY CYSTADENOCARCINOMA OF THE MAMMARY GLAND IN A BLACK-FOOTED FERRET by CARPENTER, JAMES W., DAVIDSON, JAMES P., NOVILLA, MELITON N., HUANG, JIMMY C. M.

“…A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, and spleen was observed…”
Get full text

Heart failure associated with unusual hepatic inclusions in a Deckert's rat snake by Jacobson, ER, Seely, JC, Novilla, MN, Davidson, JP

“…A juvenile Deckert's rat snake, Elaphe obsoleta deckerti, was presented with a circumferential enlargement of the body in the region of the heart. The heart…”
Get full text