Search Results - "DAVIDSEN, K"

High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression by DAVIDSEN, Peter K, GALLAGHER, Iain J, HARTMAN, Joseph W, TARNOPOLSKY, Mark A, DELA, Flemming, HELGE, Jørn W, TIMMONS, James A, PHILLIPS, Stuart M

“…MicroRNAs (miRNA), small noncoding RNA molecules, may regulate protein synthesis, while resistance exercise training (RT) is an efficient strategy for…”
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Maternal prenatal stress and postnatal depressive symptoms: discrepancy between mother and teacher reports of toddler psychological problems by Wesselhoeft, R., Davidsen, K., Sibbersen, C., Kyhl, H., Talati, A., Andersen, M. S., Bilenberg, N.

“…Purpose Maternal prenatal stress and postnatal depression are reported to increase the risk for early offspring psychological problems. We examined whether…”
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eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription by Brina, Daniela, Miluzio, Annarita, Ricciardi, Sara, Clarke, Kim, Davidsen, Peter K., Viero, Gabriella, Tebaldi, Toma, Offenhäuser, Nina, Rozman, Jan, Rathkolb, Birgit, Neschen, Susanne, Klingenspor, Martin, Wolf, Eckhard, Gailus-Durner, Valerie, Fuchs, Helmut, Hrabe de Angelis, Martin, Quattrone, Alessandro, Falciani, Francesco, Biffo, Stefano

“…Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation…”
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Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training by Takeshita, Louise Y., Davidsen, Peter K., Herbert, John M., Antczak, Philipp, Hesselink, Matthijs K. C., Schrauwen, Patrick, Weisnagel, S. John, Robbins, Jeremy M., Gerszten, Robert E., Ghosh, Sujoy, Sarzynski, Mark A., Bouchard, Claude, Falciani, Francesco

“…Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity…”
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Role of Class I and Class II histone deacetylases in carcinoma cells using siRNA by Glaser, Keith B, Li, Junling, Staver, Michael J, Wei, Ru-Qi, Albert, Daniel H, Davidsen, Steven K

“…The role of the individual histone deacetylases (HDACs) in the regulation of cancer cell proliferation was investigated using siRNA-mediated protein knockdown…”
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The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks by Clarke, Kim, Ricciardi, Sara, Pearson, Tim, Bharudin, Izwan, Davidsen, Peter K., Bonomo, Michela, Brina, Daniela, Scagliola, Alessandra, Simpson, Deborah M., Beynon, Robert J., Khanim, Farhat, Ankers, John, Sarzynski, Mark A., Ghosh, Sujoy, Pisconti, Addolorata, Rozman, Jan, Hrabe de Angelis, Martin, Bunce, Chris, Stewart, Claire, Egginton, Stuart, Caddick, Mark, Jackson, Malcolm, Bouchard, Claude, Biffo, Stefano, Falciani, Francesco

“…Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying…”
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Genomic and transcriptomic predictors of triglyceride response to regular exercise by Sarzynski, Mark A, Davidsen, Peter K, Sung, Yun Ju, Hesselink, Matthijs K C, Schrauwen, Patrick, Rice, Treva K, Rao, D C, Falciani, Francesco, Bouchard, Claude

“…We performed genome-wide and transcriptome-wide profiling to identify genes and single nucleotide polymorphisms (SNPs) associated with the response of…”
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Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor by Albert, Daniel H, Tapang, Paul, Magoc, Terrance J, Pease, Lori J, Reuter, David R, Wei, Ru-Qi, Li, Junling, Guo, Jun, Bousquet, Peter F, Ghoreishi-Haack, Nayereh S, Wang, Baole, Bukofzer, Gail T, Wang, Yi-Chun, Stavropoulos, Jason A, Hartandi, Kresna, Niquette, Amanda L, Soni, Nirupama, Johnson, Eric F, McCall, J Owen, Bouska, Jennifer J, Luo, Yanping, Donawho, Cherrie K, Dai, Yujia, Marcotte, Patrick A, Glaser, Keith B, Michaelides, Michael R, Davidsen, Steven K

“…ABT-869 is a structurally novel, receptor tyrosine kinase (RTK) inhibitor that is a potent inhibitor of members of the vascular endothelial growth factor…”
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Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes by Henriksen, Tora I, Davidsen, Peter K, Pedersen, Maria, Schultz, Heidi S, Hansen, Ninna S, Larsen, Therese J, Vaag, Allan, Pedersen, Bente K, Nielsen, Søren, Scheele, Camilla

“…Abstract Objective MicroRNAs (miRNAs) are increasingly recognized as fine-tuning regulators of metabolism, and are dysregulated in several disease conditions…”
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Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines by Glaser, Keith B, Staver, Michael J, Waring, Jeffrey F, Stender, Joshua, Ulrich, Roger G, Davidsen, Steven K

“…Acetylation of histones in chromatin is one mechanism involved in the regulation of gene transcription and is tightly controlled by the balance of…”
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Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases by McClellan, William J., Dai, Yujia, Abad-Zapatero, Cele, Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Magoc, Terry J., Marcotte, Patrick A., Osterling, Donald J., Stewart, Kent D., Davidsen, Steven K., Michaelides, Michael R.

“…In an effort to discover Aurora kinase inhibitors, an HTS hit revealed an amide containing pyrrolopyrimidine compound. Replacement of the pyrrolopyrimidine…”
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Is irisin a human exercise gene? by Timmons, James A., Baar, Keith, Davidsen, Peter K., Atherton, Philip J.

“…Arising from P. Boström et al.Nature481, 463–468 (2012)10.1038/nature10777 Boström et al. report that exercise training induces the expression of the FNDC5…”
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Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation by Tucker, L A, Zhang, Q, Sheppard, G S, Lou, P, Jiang, F, McKeegan, E, Lesniewski, R, Davidsen, S K, Bell, R L, Wang, J

“…Methionine aminopeptidase-2 (MetAP2) processes N-terminal methionine from nascent cellular proteins. Inhibition of MetAP2 has been shown to block angiogenesis…”
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ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia by Shankar, Deepa B., Li, Junling, Tapang, Paul, Owen McCall, J., Pease, Lori J., Dai, Yujia, Wei, Ru-Qi, Albert, Daniel H., Bouska, Jennifer J., Osterling, Donald J., Guo, Jun, Marcotte, Patrick A., Johnson, Eric F., Soni, Niru, Hartandi, Kresna, Michaelides, Michael R., Davidsen, Steven K., Priceman, Saul J., Chang, Jenny C., Rhodes, Katrin, Shah, Neil, Moore, Theodore B., Sakamoto, Kathleen M., Glaser, Keith B.

“…In 15% to 30% of patients with acute myeloid leukemia (AML), aberrant proliferation is a consequence of a juxtamembrane mutation in the FLT3 gene (FMS-like…”
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Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors by Guo, Jun, Marcotte, Patrick A, McCall, J Owen, Dai, Yujia, Pease, Lori J, Michaelides, Michael R, Davidsen, Steven K, Glaser, Keith B

“…The properties of several multitargeted receptor tyrosine kinase inhibitors have been studied for their inhibition of colony-stimulating factor-1 receptor…”
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Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway by Zhou, J, Pan, M, Xie, Z, Loh, S-L, Bi, C, Tai, Y-C, Lilly, M, Lim, Y-P, Han, J-H, Glaser, K B, Albert, D H, Davidsen, S K, Chen, C-S

“…Internal tandem duplications (ITDs) of fms-like tyrosine kinase 3 (FLT3) receptor play an important role in the pathogenesis of acute myeloid leukemia (AML)…”
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Thienopyrimidine Ureas as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors by Dai, Yujia, Guo, Yan, Frey, Robin R, Ji, Zhiqin, Curtin, Michael L, Ahmed, Asma A, Albert, Daniel H, Arnold, Lee, Arries, Shannon S, Barlozzari, Teresa, Bauch, Joy L, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George A, Glaser, Keith B, Guo, Jun, Li, Junling, Marcotte, Patrick A, Marsh, Kennan C, Moskey, Maria D, Pease, Lori J, Stewart, Kent D, Stoll, Vincent S, Tapang, Paul, Wishart, Neil, Davidsen, Steven K, Michaelides, Michael R

“…A series of novel thienopyrimidine-based receptor tyrosine kinase inhibitors has been discovered. Investigation of structure−activity relationships at the 5-…”
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Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR by Hajduk, P. J, Sheppard, G, Nettesheim, D. G, Olejniczak, E. T, Shuker, S. B, Meadows, R. P, Steinman, D. H, Carrera, G. M, Marcotte, P. A, Severin, J, Walter, K, Smith, H, Gubbins, E, Simmer, R, Holzman, T. F, Morgan, D. W, Davidsen, S. K, Summers, J. B, Fesik, S. W

“…With the use of an NMR-based method, potent (IC50 < 25 nM) nonpeptide inhibitors of the matrix metalloproteinase stromelysin (MMP-3) were discovered. The…”
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Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors by Dai, Yujia, Hartandi, Kresna, Soni, Niru B., Pease, Lori J., Reuter, David R., Olson, Amanda M., Osterling, Donald J., Doktor, Stella Z., Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Marcotte, Patrick A., Stewart, Kent D., Davidsen, Steven K., Michaelides, Michael R.

“…Tumor angiogenesis is mediated by KDR and other VEGFR and PDGFR kinases. Their inhibition presents an attractive approach for developing anticancer…”
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Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors by Ji, Zhiqin, Dai, Yujia, Abad-Zapatero, Cele, Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Marcotte, Patrick A., Soni, Nirupama B., Magoc, Terry J., Stewart, Kent D., Wei, Ru-Qi, Davidsen, Steve K., Michaelides, Michael R.

“…Four hinge-binding scaffolds have been explored for novel selective Aurora kinase inhibitors. The structure activity relationship, selectivity and…”
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