Search Results - "DAVID HOLTZCLAW, W"

Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase by Fahey, Jed W, Holtzclaw, W David, Wehage, Scott L, Wade, Kristina L, Stephenson, Katherine K, Talalay, Paul

“…Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that…”
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Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora by Fahey, Jed W, Wehage, Scott L, Holtzclaw, W David, Kensler, Thomas W, Egner, Patricia A, Shapiro, Theresa A, Talalay, Paul

“…Plant-based diets rich in crucifers are effective in preventing cancer and other chronic diseases. Crucifers contain very high concentrations of glucosinolates…”
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Direct Evidence That Sulfhydryl Groups of Keap1 Are the Sensors Regulating Induction of Phase 2 Enzymes That Protect against Carcinogens and Oxidants by Dinkova-Kostova, Albena T., Holtzclaw, W. David, Cole, Robert N., Itoh, Ken, Wakabayashi, Nobunao, Katoh, Yasutake, Yamamoto, Masayuki, Talalay, Paul

“…Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants…”
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Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model by Kalin, Jay H, Eroglu, Abdulkerim, Liu, Hua, Holtzclaw, W David, Leigh, Irene, Proby, Charlotte M, Fahey, Jed W, Cole, Philip A, Dinkova-Kostova, Albena T

“…Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients…”
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Protection against Electrophile and Oxidant Stress by Induction of the Phase 2 Response: Fate of Cysteines of the Keap1 Sensor Modified by Inducers by Wakabayashi, Nobunao, Dinkova-Kostova, Albena T., Holtzclaw, W. David, Kang, Moon-Il, Kobayashi, Akira, Yamamoto, Masayuki, Kensler, Thomas W., Talalay, Paul

“…Induction of a family of phase 2 genes encoding for proteins that protect against the damage of electrophiles and reactive oxygen intermediates is potentially…”
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The Role of Keap1 in Cellular Protective Responses by Dinkova-Kostova, Albena T, Holtzclaw, W. David, Kensler, Thomas W

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Extremely Potent Triterpenoid Inducers of the Phase 2 Response: Correlations of Protection against Oxidant and Inflammatory Stress by Dinkova-Kostova, Albena T., Liby, Karen T., Stephenson, Katherine K., Holtzclaw, W. David, Gao, Xiangqun, Suh, Nanjoo, Williams, Charlotte, Risingsong, Renee, Honda, Tadashi, Gribble, Gordon W., Sporn, Michael B., Talalay, Paul

“…A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-γ…”
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Inactivation of Tautomerase Activity of Macrophage Migration Inhibitory Factor by Sulforaphane: a Potential Biomarker for Anti-inflammatory Intervention by HEALY, Zachary R, HUA LIU, DAVID HOLTZCLAW, W, TALALAY, Paul

“…Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine with keto-enol tautomerase activity, rises rapidly in response to inflammation and is…”
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Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study by Shapiro, T.A, Fahey, J.W, Dinkova-Kostova, A.T, Holtzclaw, W.D, Stephenson, K.K, Wade, K.L, Ye, L, Talalay, P

“…Broccoli sprouts are widely consumed in many parts of the world. There have been no reported concerns with respect to their tolerance and safety in humans. A…”
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Exceptionally Potent Inducer of Cytoprotective Enzymes: ELUCIDATION OF THE STRUCTURAL FEATURES THAT DETERMINE INDUCER POTENCY AND REACTIVITY WITH Keap1 by Dinkova-Kostova, Albena T, Talalay, Paul, Sharkey, John, Zhang, Ying, Holtzclaw, W. David, Wang, Xiu Jun, David, Emilie, Schiavoni, Katherine H, Finlayson, Stewart, Mierke, Dale F, Honda, Tadashi

“…The Keap1/Nrf2/ARE pathway controls a network of cytoprotective genes that defend against the damaging effects of oxidative and electrophilic stress, and…”
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Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, Is a Zinc Metalloprotein by Dinkova-Kostova, Albena T, Holtzclaw, W. David, Wakabayashi, Nobunao

“…Induction of the phase 2 response, a major cellular reaction to oxidative/electrophile stress depends on a protein triad:  actin-tethered Keap1 that binds to…”
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Unexpected Genetic and Structural Relationships of a Long-Forgotten Flavoenzyme to NAD(P)H:Quinone Reductase (DT-Diaphorase) by Zhao, Qinjian, Yang, Xiao Ling, Holtzclaw, W. David, Talalay, Paul

“…A mammalian cytosolic FAD-dependent enzyme that catalyzes the reduction of quinones by N-ribosyl- and N-alkyldihydronicotinamides, but not by NADH, NADPH, or…”
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Purification of Active Myrosinase from Plants by Aqueous Two‐Phase Counter‐Current Chromatography by Wade, Kristina L, Ito, Yoichiro, Ramarathnam, Aarthi, Holtzclaw, W. David, Fahey, Jed W

“…INTRODUCTION: Myrosinase (thioglucoside glucohydrolase; E.C. 3.2.1.147), is a plant enzyme of increasing interest and importance to the biomedical community…”
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An Exceptionally Potent Inducer of Cytoprotective Enzymes by Dinkova-Kostova, Albena T., Talalay, Paul, Sharkey, John, Zhang, Ying, Holtzclaw, W. David, Wang, Xiu Jun, David, Emilie, Schiavoni, Katherine H., Finlayson, Stewart, Mierke, Dale F., Honda, Tadashi

“…The Keap1/Nrf2/ARE pathway controls a network of cytoprotective genes that defend against the damaging effects of oxidative and electrophilic stress, and…”
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Chemical and Molecular Regulation of Enzymes that Detoxify Carcinogens by Prestera, Tory, Holtzclaw, W. David, Zhang, Yuesheng, Talalay, Paul

“…Inductions of detoxication (phase 2) enzymes, such as glutathione transferases and NAD(P)H:(quinoneacceptor) oxidoreductase, are a major mechanism for…”
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An unusual case of ‘uncompetitive activation’ by ascorbic acid: purification and kinetic properties of a myrosinase from Raphanus sativus seedlings by SHIKITA, Mikio, FAHEY, Jed W., GOLDEN, Tamara R., David HOLTZCLAW, W., TALALAY, Paul

“…Myrosinase (thioglucoside glucohydrolase; EC 3.2.3.1) is a plant enzyme that hydrolyses glucosinolates, principally to isothiocyanates. Myrosinase was purified…”
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Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis by Talalay, Paul, Dinkova-Kostova, Albena T, Holtzclaw, W David

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Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers by Holtzclaw, W David, Dinkova-Kostova, Albena T, Talalay, Paul

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Chemoprotection against cancer by Phase 2 enzyme induction by Talalay, Paul, Fahey, Jed W., Holtzclaw, W.David, Prestera, Tory, Zhang, Yuesheng

“…Mammalian cells have evolved elaborate mechanisms for protection against the toxic and neoplastic effects of electrophilic metabolites of carcinogens and…”
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An unusual case of 'uncompetitive activation' by ascorbic acid: purification and kinetic properties of a myrosinase from Raphanus sativus seedlings by Shikita, M, Fahey, J W, Golden, T R, Holtzclaw, W D, Talalay, P

“…Myrosinase (thioglucoside glucohydrolase; EC 3.2.3.1) is a plant enzyme that hydrolyses glucosinolates, principally to isothiocyanates. Myrosinase was purified…”
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