Search Results - "DAVID FURLOW, J"

Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling by Tandon, Panna, Conlon, Frank, Furlow, J. David, Horb, Marko E.

“…The amphibian model Xenopus, has been used extensively over the past century to study multiple aspects of cell and developmental biology. Xenopus offers…”
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Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids by Baehr, Leslie M., Furlow, J. David, Bodine, Sue C.

“…Non‐Technical Summary  Skeletal muscle has the capacity to modify its size in response to external cues such as mechanical load, neural activity, hormones,…”
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Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay by Freitas, Jaime, Cano, Patricia, Craig-Veit, Christina, Goodson, Michael L., David Furlow, J., Murk, Albertinka J.

“…A stable luciferase reporter gene assay was developed based on the thyroid hormone responsive rat pituitary tumor GH3 cell line that constitutively expresses…”
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A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure by Watson, Monica L, Baehr, Leslie M, Reichardt, Holger M, Tuckermann, Jan P, Bodine, Sue C, Furlow, J David

“…Glucocorticoids (GCs) are important regulators of skeletal muscle mass, and prolonged exposure will induce significant muscle atrophy. To better understand the…”
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Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals by Murk, AlberTinka J., Rijntjes, Eddy, Blaauboer, Bas J., Clewell, Rebecca, Crofton, Kevin M., Dingemans, Milou M.L., David Furlow, J., Kavlock, Robert, Köhrle, Josef, Opitz, Robert, Traas, Theo, Visser, Theo J., Xia, Menghang, Gutleb, Arno C.

“…The thyroid hormone (TH) system is involved in several important physiological processes, including regulation of energy metabolism, growth and…”
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Retinoid-X receptor agonists increase thyroid hormone competence in lower jaw remodeling of pre-metamorphic Xenopus laevis tadpoles by Mengeling, Brenda J, Vetter, Lara F, Furlow, J David

“…Thyroid hormone (TH) signaling plays critical roles during vertebrate development, including regulation of skeletal and cartilage growth. TH acts through its…”
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The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene by Waddell, David S, Baehr, Leslie M, van den Brandt, Jens, Johnsen, Steven A, Reichardt, Holger M, Furlow, J David, Bodine, Sue C

“…The muscle specific ubiquitin E3 ligase MuRF1 has been implicated as a key regulator of muscle atrophy under a variety of conditions, such as during synthetic…”
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RXR Ligands Modulate Thyroid Hormone Signaling Competence in Young Xenopus laevis Tadpoles by Mengeling, Brenda J, Goodson, Michael L, Furlow, J David

“…Abstract Appropriate thyroid hormone (TH) signaling through thyroid hormone receptors (TRs) is essential for vertebrate development. Amphibian metamorphosis is…”
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Upregulation of proteasome activity in muscle RING finger 1‐null mice following denervation by Gomes, Aldrin V., Waddell, Dave S., Siu, Rylie, Stein, Matthew, Dewey, Shannamar, Furlow, J. David, Bodine, Sue C.

“…ABSTRACT Deletion of muscle RING finger 1 (MuRF1), an E3 ubiquitin ligase, leads to sparing of muscle mass following denervation. The purpose of this study was…”
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A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-associated Skeletal Muscle Wasting by CLARK FILES, D, D'ALESSIO, Franco R, WILLIS, Monte S, PATTERSON, Cam, TANKERSLEY, Clarke G, MESSI, Maria L, CHUN LIU, DELBONO, Osvaldo, DAVID FURLOW, J, BODINE, Sue C, COHN, Ronald D, KING, Landon S, JOHNSTON, Laura F, CROW, Michael T, KESARI, Priya, AGGARWAL, Neil R, GARIBALDI, Brian T, MOCK, Jason R, SIMMERS, Jessica L, DEGORORDO, Antonio, MURDOCH, Jared

“…Acute lung injury (ALI) is a debilitating condition associated with severe skeletal muscle weakness that persists in humans long after lung injury has…”
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Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis by Denver, Robert J., Hu, Fang, Scanlan, Thomas S., Furlow, J. David

“…Thyroid hormone (T3) influences cell proliferation, death and differentiation during development of the central nervous system (CNS). Hormone action is…”
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A developmental switch induced by thyroid hormone: Xenopus laevis metamorphosis by Furlow, J. David, Neff, Eric S.

“…Thyroid hormone induces the complete metamorphosis of anuran tadpoles into juvenile frogs. Arguably, anuran metamorphosis is the most dramatic effect of a…”
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Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy by Furlow, J David, Watson, Monica L, Waddell, David S, Neff, Eric S, Baehr, Leslie M, Ross, Adam P, Bodine, Sue C

“…Muscle atrophy can result from inactivity or unloading on one hand or the induction of a catabolic state on the other. Muscle-specific ring finger 1 (MuRF1), a…”
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Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity by Singh, Latika, Pressly, Brandon, Mengeling, Brenda J, Fettinger, James C, Furlow, J. David, Lein, Pamela J, Wulff, Heike, Singh, Vikrant

“…We have synthesized and established the structure of a long-suspected, but hitherto unknown, benzofuran side product (EBI) formed during the synthesis of NH-3…”
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Glucocorticoids and Skeletal Muscle by Bodine, Sue C, Furlow, J David

“…Glucocorticoids are known to regulate protein metabolism in skeletal muscle, producing a catabolic effect that is opposite that of insulin. In many catabolic…”
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A Thyroid Hormone Antagonist That Inhibits Thyroid Hormone Action in Vivo by Lim, Wayland, Nguyen, Ngoc-Ha, Yang, Ha Yung, Scanlan, Thomas S, Furlow, J David

“…We have characterized the newly developed thyroid hormone antagonist NH-3 in both cell culture and in vivo model systems. NH-3 binds Xenopus laevis thyroid…”
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Disruption of thyroid hormone-mediated Xenopus laevis tadpole tail tip regression by hexabromocyclododecane (HBCD) and 2,2′,3,3′,4,4′,5,5′,6-nona brominated diphenyl ether (BDE206) by Schriks, Merijn, Zvinavashe, Elton, David Furlow, J., Murk, Albertinka J.

“…Thyroid hormone regulates amphibian metamorphosis, including the transformation of a tadpole into a froglet and regression of the tail. Xenopus laevis tadpole…”
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In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor by Tachachartvanich, Phum, Singam, Ettayapuram Ramaprasad Azhagiya, Durkin, Kathleen A., Furlow, J. David, Smith, Martyn T., La Merrill, Michele A.

“…Per- and poly-fluoroalkyl substances (PFASs) are used extensively in a broad range of industrial applications and consumer products. While a few legacy PFASs…”
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Prediction of the Interactions of a Large Number of Per- and Poly-Fluoroalkyl Substances with Ten Nuclear Receptors by Azhagiya Singam, Ettayapuram Ramaprasad, Durkin, Kathleen A., La Merrill, Michele A., Furlow, J. David, Wang, Jen-Chywan, Smith, Martyn T.

“…Per- and poly-fluoroalkyl substances (PFASs) are persistent, toxic chemicals that pose significant hazards to human health and the environment. Screening large…”
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The Transcription Factor Basic Transcription Element-Binding Protein 1 Is a Direct Thyroid Hormone Response Gene in the Frog Xenopus laevis by Furlow, J. David, Kanamori, Akira

“…Several genes have been identified that are activated or repressed by thyroid hormone in tadpole tissues during metamorphosis of the frog Xenopus laevis. One…”
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