Search Results - "DAVID, JOSHUA A."

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus by Ceradini, Daniel J., Rabbani, Piul S., Rifkin, William J., David, Joshua A.

“…Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this disease remains a major source of morbidity and mortality worldwide,…”
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Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection by Flyak, Andrew I., Shen, Xiaoli, Murin, Charles D., Turner, Hannah L., David, Joshua A., Fusco, Marnie L., Lampley, Rebecca, Kose, Nurgun, Ilinykh, Philipp A., Kuzmina, Natalia, Branchizio, Andre, King, Hannah, Brown, Leland, Bryan, Christopher, Davidson, Edgar, Doranz, Benjamin J., Slaughter, James C., Sapparapu, Gopal, Klages, Curtis, Ksiazek, Thomas G., Saphire, Erica Ollmann, Ward, Andrew B., Bukreyev, Alexander, Crowe, James E.

“…Recent studies have suggested that antibody-mediated protection against the Ebolaviruses may be achievable, but little is known about whether or not antibodies…”
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Achievements and Challenges in Facial Transplantation by Rifkin, William J, David, Joshua A, Plana, Natalie M, Kantar, Rami S, Diaz-Siso, J Rodrigo, Gelb, Bruce E, Ceradini, Daniel J, Rodriguez, Eduardo D

“…The first facial transplantation in 2005 ushered in a new era in reconstructive surgery, offering new possibilities for the repair of severe disfigurements…”
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Microenvironmental cues enhance mesenchymal stem cell-mediated immunomodulation and regulatory T-cell expansion by Kadle, Rohini L, Abdou, Salma A, Villarreal-Ponce, Alvaro P, Soares, Marc A, Sultan, Darren L, David, Joshua A, Massie, Jonathan, Rifkin, William J, Rabbani, Piul, Ceradini, Daniel J

“…Mesenchymal stem cells (MSCs) are known to both have powerful immunosuppressive properties and promote allograft tolerance. Determining the environmental…”
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2 by Singh, Ranjan K, Soliman, Ahmed, Guaitoli, Giambattista, Störmer, Eliza, von Zweydorf, Felix, Dal Maso, Thomas, Oun, Asmaa, Van Rillaer, Laura, Schmidt, Sven H, Chatterjee, Deep, David, Joshua A, Pardon, Els, Schwartz, Thomas U, Knapp, Stefan, Kennedy, Eileen J, Steyaert, Jan, Herberg, Friedrich W, Kortholt, Arjan, Gloeckner, Christian Johannes, Versées, Wim

“…Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson's disease (PD), while LRRK2…”
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Use of Tranexamic Acid to Reduce Blood Loss in Liposuction by Cansancao, Alvaro Luiz, Condé-Green, Alexandra, David, Joshua A., Cansancao, Bethania, Vidigal, Rafael A.

“…The use of tranexamic acid for blood loss prevention has gained popularity in many specialties, including plastic surgery. However, its use in liposuction has…”
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Circumferential Surgical Contouring of the Upper and Lower Body by David, Joshua A., Gusenoff, Jeffrey A.

“…Body contouring surgeons encounter a wide range of deformities affecting multiple areas of the body. Combining and staging procedures can assist in optimizing…”
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Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing by Rabbani, Piul S, Zhou, Anna, Borab, Zachary M, Frezzo, Joseph A, Srivastava, Nikita, More, Haresh T, Rifkin, William J, David, Joshua A, Berens, Samuel J, Chen, Raymond, Hameedi, Sophia, Junejo, Muhammad H, Kim, Camille, Sartor, Rita A, Liu, Che F, Saadeh, Pierre B, Montclare, Jin K, Ceradini, Daniel J

“…Abstract Therapeutics utilizing siRNA are currently limited by the availability of safe and effective delivery systems. Cutaneous diseases, specifically ones…”
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Cell-free plasma next-generation sequencing assists in the evaluation of secondary pneumonia in patients with COVID-19: a case series by David, Joshua A., Kolipakkam, Bharadhwaj, Morales, Megan K., Vissichelli, Nicole C.

“…Secondary pneumonia occurs in 8–24% of patients with Coronavirus 2019 (COVID-19) infection and is associated with increased morbidity and mortality. Diagnosis…”
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Subcutaneous-Only Gluteal Fat Grafting: A Prospective Study of the Long-Term Results with Ultrasound Analysis by Cansancao, Alvaro Luiz, Condé-Green, Alexandra, David, Joshua A., Vidigal, Rafael A.

“…In recent years, gluteal fat augmentation has exhibited some of the most significant growth among all plastic surgery procedures. However, as the popularity of…”
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Keratinocyte-Macrophage Crosstalk by the Nrf2/Ccl2/EGF Signaling Axis Orchestrates Tissue Repair by Villarreal-Ponce, Alvaro, Tiruneh, Melat Worku, Lee, Jasmine, Guerrero-Juarez, Christian F., Kuhn, Joseph, David, Joshua A., Dammeyer, Kristen, Mc Kell, Renee, Kwong, Jennifer, Rabbani, Piul S., Nie, Qing, Ceradini, Daniel J.

“…Unveiling the molecular mechanisms underlying tissue regeneration provides new opportunities to develop treatments for diabetic ulcers and other chronic skin…”
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Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds by Rabbani, Piul S., Ellison, Trevor, Waqas, Bukhtawar, Sultan, Darren, Abdou, Salma, David, Joshua A, Cohen, Joshua M., Gomez-Viso, Alejandro, Lam, Gretl, Kim, Camille, Thomson, Jennifer, Ceradini, Daniel J.

“…Though unmitigated oxidative stress in diabetic chronic non-healing wounds poses a major therapeutic challenge, currently, there are no effective…”
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589-P: Impaired Endothelial Nrf2 Expression Reduces Wound Neovascularization in Diabetic Mice by LEE, JASMINE, VILLARREAL PONCE, ALVARO P., DAVID, JOSHUA A., KUHN, JOSEPH, KWONG, JENNIFER, CERADINI, DANIEL

“…The global cost of diabetes in the U.S. is 1.3 trillion dollars, with chronic diabetic foot ulcers accounting for up to 13 billion dollars annually. An…”
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Revisiting the Reverse Sural Artery Flap in Distal Lower Extremity Reconstruction: A Systematic Review and Risk Analysis by Daar, David A., Abdou, Salma A., David, Joshua A., Kirby, David J., Wilson, Stelios C., Saadeh, Pierre B.

“…BACKGROUNDThe reverse sural artery flap (RSAF) is a popular option for patients with distal lower extremity defects who are not ideal candidates for free flap…”
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A Prospective, Randomized, Blinded Trial Comparing Digital Simulation to Textbook for Cleft Surgery Education by Plana, Natalie M., Rifkin, William J., Kantar, Rami S., David, Joshua A., Maliha, Samantha G., Farber, Scott J., Staffenberg, David A., Grayson, Barry H., Diaz-Siso, J. Rodrigo, Flores, Roberto L.

“…BACKGROUND:Simulation is progressively being integrated into surgical training; however, its utility in plastic surgery has not been well described. The…”
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Current Management of Self-Inflicted Wounds in Surgery: A Critical Review by David, Joshua A, Rifkin, William J, Chiu, Ernest S

“…OBJECTIVEDespite the presence of self-inflicted wounds (SIWs) across all of medicine, our current understanding of SIWs in surgery is limited. Here, we detail…”
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Abdominal Panniculectomy: Determining the Impact of Diabetes on Complications and Risk Factors for Adverse Events by Kantar, Rami S., Rifkin, William J., Wilson, Stelios C., David, Joshua A., Diaz-Siso, J. Rodrigo, Levine, Jamie P., Golas, Alyssa R., Ceradini, Daniel J.

“…BACKGROUND:The prevalence of obesity along with bariatric surgery and massive weight loss requiring panniculectomy is increasing in the United States. The…”
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592-P: Epidermal Nrf2 Orchestrates Tissue Regeneration through Direction Regulation of Ccl2 by VILLARREAL PONCE, ALVARO P., TIRUNEH-WORKU, MELAT, LEE, JASMINE, DAVID, JOSHUA A., GUERRERO-JUAREZ, CHRIS, DAMMEYER, KRISTEN, KUHN, JOSEPH, KWONG, JENNIFER, CERADINI, DANIEL

“…Diabetic ulcers are costly chronic wounds and are the leading cause of lower-extremity amputations. Dysfunctional redox balance underlies a key part of…”
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71-OR: Dynamic Nrf2 Expression in Cutaneous Wounds Regulates Skin Reepithelialization by VILLARREAL PONCE, ALVARO P., DAVID, JOSHUA A., TIRUNEH, MELAT WORKU, ABDOU, SALMA, SULTAN, DARREN, KWONG, JENNIFER, KUHN, JOSEPH, RABBANI, PIUL S., CERADINI, DANIEL

“…Diabetic ulcers are chronic cutaneous complications that amount to more than $50M in healthcare costs and are the leading cause of lower extremity amputations…”
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623-P: Impaired Nrf2 Function Corresponds with Delayed Wound Healing in Diabetes by KUHN, JOSEPH, DAVID, JOSHUA A., VILLARREAL PONCE, ALVARO P., ABDOU, SALMA, SULTAN, DARREN, KWONG, JENNIFER, RABBANI, PIUL S., CERADINI, DANIEL

“…Imbalance in the production of reactive oxygen species predisposes diabetic patients to delayed wound healing, but treatments that directly address this…”
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