Search Results - "DAUCHY, R. T"

Mechanism for the antitumor and anticachectic effects of n-3 fatty acids by SAUER, Leonard A, DAUCHY, Robert T, BLASK, David E

“…Dietary intake of the n-6 fatty acid (FA) linoleic acid (LA) has a strong growth-promoting effect on many rodent tumors and human tumor xenografts grown in…”
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Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events by BLASK, D. E, SAUER, L. A, DAUCHY, R. T, HOLOWACHUK, E. W, RUHOFF, M. S, KOPFF, H. S

“…The growth of rat hepatoma 7288CTC in vivo is stimulated by the uptake of linoleic acid (LA) and its metabolism to 13-hydroxyoctadecadienoic acid (13-HODE), an…”
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13-Hydroxyoctadecadienoic acid is the mitogenic signal for linoleic acid-dependent growth in rat hepatoma 7288CTC in vivo by SAUER, L. A, DAUCHY, R. T, BLASK, D. E, ARMSTRONG, B. J, SCALICI, S

“…Growth of hepatoma 7288CTC in male Buffalo rats is directly dependent on uptake of linoleic acid (LA) from the arterial blood. One to 5% of the LA taken up is…”
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Dim light during darkness stimulates tumor progression by enhancing tumor fatty acid uptake and metabolism by Dauchy, Robert T, Blask, David E, Sauer, Leonard A, Brainard, George C, Krause, Jean A

“…Tumor linoleic acid uptake and metabolism, and growth are suppressed by melatonin, the synthesis of which is inhibited by light. Linoleic acid, via its…”
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Uptake of plasma lipids by tissue-isolated hepatomas 7288CTC and 7777 in vivo by SAUER, L. A, DAUCHY, R. T

“…The uptake of myristic (C14:0), palmitic (C16:0), palmitoleic (C:16,N-7), stearic (C18:0), oleic (C18:1,N-9), linoleic (C18:2,N-6) and arachidonic (C20:4,N-6)…”
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Dietary linoleic acid intake controls the arterial blood plasma concentration and the rates of growth and linoleic acid uptake and metabolism in hepatoma 7288CTC in Buffalo rats by Sauer, L A, Dauchy, R T, Blask, D E

“…In this study, we tested the hypothesis that dietary linoleic acid intake controls the arterial blood plasma linoleic acid concentration and the rates of tumor…”
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The effect of omega-6 and omega-3 fatty acids on 3H-thymidine incorporation in hepatoma 7288CTC perfused in situ by SAUER, L. A, DAUCHY, R. T

“…Ingestion of diets containing corn oil or marine fish oils is known to increase or decrease, respectively, the growth of transplantable rodent tumours. The…”
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Polyunsaturated fatty acids, melatonin, and cancer prevention by SAUER, Leonard A, DAUCHY, Robert T, BLASK, David E

“…Many nutritional, hormonal, and environmental factors affect carcinogenesis and growth of established tumors in rodents. In some cases, these factors may…”
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Lactate release and uptake in hepatoma 7288CTC perfused in situ with L-[(U)-14C]lactate or D-[(U)-14C]glucose by Sauer, L A, Dauchy, R T

“…Arteriovenous differences (AVD) for glucose and lactic acid measured across tissue-isolated rat tumors in vivo have shown that individual tumors with similar…”
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Regulation of lactate production and utilization in rat tumors in vivo by Sauer, L A, Dauchy, R T

“…These experiments were performed to determine the factor(s) that regulate lactic acid production and utilization by rat tumors in vivo. Arteriovenous…”
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Tumour-host metabolic interrelationships by Sauer, L A, Dauchy, R T

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Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction by Sauer, Leonard A., Dauchy, Robert T., Blask, David E.

“…Melatonin inhibits fatty acid uptake and linoleic acid-dependent growth in hepatoma 7288CTC in vivo in Buffalo rats. In this study we measured the effects of…”
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Mitochondrial malic enzymes. An association between NAD(P)+-dependent malic enzyme and cell renewal in Sprague-Dawley rat tissues by Nagel, W O, Dauchy, R T, Sauer, L A

“…The activities of the mitochondrial NAD(P)+- and NADP+-dependent malic enzymes were measured in 11 tissues of the male Sprague-Dawley rat. The…”
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New insights into melatonin regulation of cancer growth by Blask, D E, Sauer, L A, Dauchy, R T, Holowachuk, E W, Ruhoff, M S

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Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy by Blask, David E, Sauer, Leonard A, Dauchy, Robert T

“…Melatonin, as a new member of an expanding group of regulatory factors that control cell proliferation and loss, is the only known chronobiotic, hormonal…”
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Identification of linoleic and arachidonic acids as the factors in hyperlipemic blood that increase [3H]thymidine incorporation in hepatoma 7288CTC perfused in situ by SAUER, L. A, DAUCHY, R. T

“…Tumor growth and the incorporation of [3H]thymidine into tumor DNA in vivo are increased about 3 times in adult rats (greater than 250 g) after 1 to 2 days of…”
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Identification of an NAD(P)+-dependent 'malic' enzyme in small-intestinal-mucosal mitochondria by Sauer, L A, Dauchy, R T, Nagel, W O

“…An NAD(P)+-dependent 'malic' enzyme is shown to be present in mitochondria from small-intestinal mucosa. The intracellular location, activity and regulatory…”
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Stimulation of tumor growth in adult rats in vivo during acute streptozotocin-induced diabetes by SAUER, L. A, DAUCHY, R. T

“…The effects of acute diabetes mellitus on the growth of Morris hepatoma 7288CTC and Jensen sarcoma were studied in fed, young (less than 200 g), and adult…”
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Preparation of "tissue-isolated" rat tumors for perfusion: a new surgical technique that preserves continuous blood flow by Dauchy, R T, Sauer, L A

“…A surgical technique for preparing "tissue-isolated" rat tumors for perfusion was developed that ensures continuous blood flow to the tissue. The tumor may be…”
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Stimulation of tumor growth in adult rats in vivo during an acute fast by SAUER, L. A, NAGEL, W. O, DAUCHY, R. T, MICELI, L. A, AUSTIN, J. E

“…These experiments investigate an increase in tumor growth that occurs in adult rats in vivo during an acute fast. The effects of feeding, fasting, and…”
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