Search Results - "DATO, S"

Contribution of genetic polymorphisms on functional status at very old age: A gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway by Dato, S., Soerensen, M., Lagani, V., Montesanto, A., Passarino, G., Christensen, K., Tan, Q., Christiansen, L.

“…Preservation of functional ability is a well-recognized marker of longevity. At a molecular level, a major determinant of the physiological decline occurring…”
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Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly by Rose, G, Dato, S, Altomare, K, Bellizzi, D, Garasto, S, Greco, V, Passarino, G, Feraco, E, Mari, V, Barbi, C, BonaFe, M, Franceschi, C, Tan, Q, Boiko, S, Yashin, A.I, De Benedictis, G

“…The human sirtuin 3 ( SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of…”
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Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing) by Cevenini, E., Cotichini, R., Stazi, M. A., Toccaceli, V., Palmas, M. G., Capri, M., De Rango, F., Dato, S., Passarino, G., Jeune, B., Franceschi, C.

“…In a scenario of increasing life expectancy worldwide, it is mandatory to identify the characteristics of a healthy aging phenotype, including survival…”
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Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13 by Bellizzi, D., Dato, S., Cavalcante, P., Covello, G., Di Cianni, F., Passarino, G., Rose, G., De Benedictis, G.

“…The human SIRT3 gene contains an intronic VNTR enhancer whose variability is correlated with life span. The SIRT3 5′ flanking region encompasses the PSMD13…”
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Genetics of longevity by Mari, V, Dato, S

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Editorial: Evidence-Based Medicine by Sivananthan, Dato KS

“…A1 Khudairy et al.7 reported that withholding clopidogrel for <7 days before hip fracture surgery had no discernible effect on patients, although the sample…”
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Genes and longevity : a genetic-demographic approach reveals sex-and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci) by DATO, S, CAROTENUTO, L, DE BENEDICTIS, G

“…Association analyses between gene variability and human longevity carried out by comparing gene frequencies between population samples of different ages…”
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Postprandial hyperglycemia and hyperlipidemia-generated glycoxidative stress: its contribution to the pathogenesis of diabetes complications by Rebolledo, O R, Actis Dato, S M

“…Postprandial glucose and triglyceride increments after a mixed meal are more prolonged in people with type 1 and 2 diabetes or with impaired glucose tolerance…”
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Cognitive Functioning and Survival in the Elderly: The SSADH C538T Polymorphism by De Rango, F., Leone, O., Dato, S., Novelletto, A., Bruni, A. C., Berardelli, M., Mari, V., Feraco, E., Passarino, G., De Benedictis, G.

“…Summary The variability of the Succinic Semialdehyde Dehydrogenase (SSADH, or ALDH5A1) gene affects both pathological and normal phenotypes correlated to…”
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The allele (A)-110 in the promoter region of the HSP70-1 gene is unfavorable to longevity in women by ALTOMARE, K, GRECO, V, PASSARINO, G, FRANCESCHI, C, DE BENEDICTIS, G, BELLIZZI, D, BERARDELLI, M, DATO, S, DERANGO, F, GARASTO, S, ROSE, G, FERACO, E, MARI, V

“…Heat shock proteins (HSPs) are crucial for maintenance of cell homeostasis and survival both during and after various stresses. The capability to cope with…”
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Large-scale preventive chemotherapy for the control of helminth infection in Western Pacific countries: six years later by Montresor, Antonio, Cong, Dai Tran, Sinuon, Mouth, Tsuyuoka, Reiko, Chanthavisouk, Chitsavang, Strandgaard, Hanne, Velayudhan, Raman, Capuano, Corinne M, Le Anh, Tuan, Tee Dató, Ah S

“…In 2001, Urbani and Palmer published a review of the epidemiological situation of helminthiases in the countries of the Western Pacific Region of the World…”
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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages by Bellizzi, Dina, Rose, Giuseppina, Cavalcante, Paola, Covello, Giuseppina, Dato, Serena, De Rango, Francesco, Greco, Valentina, Maggiolini, Marcello, Feraco, Emidio, Mari, Vincenzo, Franceschi, Claudio, Passarino, Giuseppe, De Benedictis, Giovanna

“…SIR2 genes control life span in model organisms, playing a central role in evolutionarily conserved pathways of aging and longevity. We wanted to verify…”
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A cross-section analysis of FT3 age-related changes in a group of old and oldest-old subjects, including centenarians’ relatives, shows that a down-regulated thyroid function has a familial component and is related to longevity by Corsonello, Andrea, Montesanto, Alberto, Berardelli, Maurizio, De Rango, Francesco, Dato, Serena, Mari, Vincenzo, Mazzei, Bruno, Lattanzio, Fabrizia, Passarino, Giuseppe

“…Background: several studies suggest that a decreased thyroid activity might be favourable in oldest-old subjects and that subclinical thyroid hyperfunction may…”
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TP53P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis by Di Pietro, Fabio, Dato, Serena, Carpi, Francesco M, Corneveaux, Jason J, Serfaustini, Simona, Maoloni, Sebastiano, Mignini, Fiorenzo, Huentelman, Matthew J, Passarino, Giuseppe, Napolioni, Valerio

“…The association of TP53 P72R (rs1042522) with longevity remains uncertain and varies with ethnicity. Here, we tested its association with longevity in a…”
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Association of the mitochondrial DNA haplogroup J with longevity is population specific by DATO, Serena, PASSARINO, Giuseppe, ROSE, Giuseppina, ALTOMARE, Katia, BELLIZZI, Dina, MARI, Vincenzo, FERACO, Emidio, FRANCESCHI, Claudio, DE BENEDICTIS, Giovanna

“…Evidences are accumulating on the effects of the variability of mitochondrial DNA (mtDNA) on many complex traits. In particular, mtDNA haplogroup J has been…”
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Commonly Studied Polymorphisms in Inflammatory Cytokine Genes Show Only Minor Effects on Mortality and Related Risk Factors in Nonagenarians by Dato, Serena, Krabbe, Karen S., Thinggaard, Mikael, Pedersen, Bente K., Christensen, Kaare, Bruunsgaard, Helle, Christiansen, Lene

“…Systemic low-grade inflammation is consistently associated with functional status, cognitive functioning, multimorbidity, and survival in oldest olds. If…”
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A Genetic–Demographic Approach Reveals Male-Specific Association Between Survival and Tumor Necrosis Factor (A/G)-308 Polymorphism by Cardelli, Maurizio, Cavallone, Luca, Marchegiani, Francesca, Oliveri, Fabiola, Dato, Serena, Montesanto, Alberto, Lescai, Francesco, Lisa, Rosamaria, De Benedictis, Giovanna, Franceschi, Claudio

“…The (A/G)-308 polymorphism of the tumor necrosis factor α gene (TNF) is associated with age-related diseases, but its influence on longevity is controversial…”
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Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity by Marini, Marina, Lapalombella, Rosa, Canaider, Silvia, Farina, Antonio, Monti, Daniela, De Vescovi, Valentina, Morellini, Marina, Bellizzi, Dina, Dato, Serena, De Benedictis, Giovanna, Passarino, Giuseppe, Moresi, Raffaella, Tesei, Silvia, Franceschi, Claudio

“…‘Successful aging’, i.e. the ability to attain old age in relatively good health, is believed to be related to the capability to cope with different…”
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The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women by Altomare, K, Greco, V, Bellizzi, D, Berardelli, M, Dato, S, DeRango, F, Garasto, S, Rose, G, Feraco, E, Mari, V, Passarino, G, Franceschi, C, De Benedictis, G

“…Heat shock proteins (HSPs) are crucial for maintenance of cell homeostasis and survival both during and after various stresses. The capability to cope with…”
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Comparative effects of docosa‐4,7,10,13,16‐pentaenoic acid and docosa‐4,7,10,13,16,19‐hexaenoic acid on the desaturation of linoleic acid and α‐linolenic acid by Actis Dato, S. M., Brenner, R. R.

“…Varying concentrations of free docosa‐4,7,10,13,16‐pentaenoic acid or its CoA ester were incubated with a given variable concentration of 1‐14C‐linoleate or…”
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