Search Results - "DASSANAYAKA, Sujith"

Hemodynamic Support With a Microaxial Percutaneous Left Ventricular Assist Device (Impella) Protects Against Acute Kidney Injury in Patients Undergoing High-Risk Percutaneous Coronary Intervention by Flaherty, Michael P, Pant, Sadip, Patel, Samir V, Kilgore, Tyler, Dassanayaka, Sujith, Loughran, John H, Rawasia, Wasiq, Dawn, Buddhadeb, Cheng, Allen, Bartoli, Carlo R

“…RATIONALE:Acute kidney injury (AKI) is common during high-risk percutaneous coronary intervention (PCI), particularly in those with severely reduced left…”
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Airn Regulates Igf2bp2 Translation in Cardiomyocytes by Hosen, Mohammed Rabiul, Militello, Giuseppe, Weirick, Tyler, Ponomareva, Yuliya, Dassanayaka, Sujith, Moore, Joseph B, Döring, Claudia, Wysoczynski, Marcin, Jones, Steven P, Dimmeler, Stefanie, Uchida, Shizuka

“…RATIONALE:Increasing evidence indicates the presence of lncRNAs in various cell types. Airn is an imprinting gene transcribed from the paternal chromosome. It…”
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Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction by Dassanayaka, Sujith, Brittian, Kenneth R, Long, Bethany W, Higgins, Lauren A, Bradley, James A, Audam, Timothy N, Jurkovic, Andrea, Gumpert, Anna M, Harrison, Linda T, Hartyánszky, István, Perge, Péter, Merkely, Béla, Radovits, Tamás, Hanover, John A, Jones, Steven P

“…The beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults. To this end, increased protein…”
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Insights into the mechanism(s) of von Willebrand factor degradation during mechanical circulatory support by Bartoli, Carlo R., MD, PhD, Dassanayaka, Sujith, MS, Brittian, Kenneth R., BS, Luckett, Andrew, MD, Sithu, Srinivas, PhD, Siess, Thorsten, PhD, Raess, Daniel H., MD, Spence, Paul A., MD, Koenig, Steven C., PhD, Dowling, Robert D., MD, D'Souza, Stanley E., PhD

“…Objective Left ventricular assist device support produces a bleeding diathesis. Evidence suggests a major role for von Willebrand factor (vWF). We examined vWF…”
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Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload by Dassanayaka, Sujith, Zheng, Yuting, Gibb, Andrew A., Cummins, Timothy D., McNally, Lindsey A., Brittian, Kenneth R., Jagatheesan, Ganapathy, Audam, Timothy N., Long, Bethany W., Brainard, Robert E., Jones, Steven P., Hill, Bradford G.

“…Pathological cardiac remodeling during heart failure is associated with higher levels of lipid peroxidation products and lower abundance of several aldehyde…”
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A New Method to Stabilize C-Kit Expression in Reparative Cardiac Mesenchymal Cells by Wysoczynski, Marcin, Dassanayaka, Sujith, Zafir, Ayesha, Ghafghazi, Shahab, Long, Bethany W, Noble, Camille, DeMartino, Angelica M, Brittian, Kenneth R, Bolli, Roberto, Jones, Steven P

“…Cell therapy improves cardiac function. Few cells have been investigated more extensively or consistently shown to be more effective than c-kit sorted cells;…”
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Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy by Dassanayaka, Sujith, Brainard, Robert E., Watson, Lewis J., Long, Bethany W., Brittian, Kenneth R., DeMartino, Angelica M., Aird, Allison L., Gumpert, Anna M., Audam, Timothy N., Kilfoil, Peter J., Muthusamy, Senthilkumar, Hamid, Tariq, Prabhu, Sumanth D., Jones, Steven P.

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Direct Measurement of Blood Flow in Microvessels Grown in Matrigel In Vivo by Bartoli, Carlo R., Ph.D, Dassanayaka, Sujith, M.S, Brittian, Kenneth, B.S, Nadar, Arun C, Ismahil, Mohamed A., Ph.D, Koenig, Steven C., Ph.D, Prabhu, Sumanth D., M.D

“…Background The Matrigel assay provides a versatile platform to examine vessel growth. Similarly, the microsphere method is used extensively in laboratory…”
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O-GlcNAc and the cardiovascular system by DASSANAYAKA, Sujith, JONES, Steven P

“…The cardiovascular system is capable of robust changes in response to physiologic and pathologic stimuli through intricate signaling mechanisms. The area of…”
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Recent Developments in Heart Failure by Dassanayaka, Sujith, Jones, Steven P

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Abstract P2104: Branched-chain Amino Acids Are Required For Acquisition Of The Cardiac Myofibroblast Phenotype by Nguyen, Daniel C, Wells, Collin, Dassanayaka, Sujith, Jones, Steven P, Hill, Bradford G

“…Abstract only Introduction: Branched-chain amino acids (BCAAs) are critical mediators of anabolic signaling and are essential for cell growth. Findings in both…”
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Abstract P2014: Chitinase-3-like-1 Is A Neutrophil Secreted Factor That Antagonizes Replacement Fibrosis And Exacerbates Cardiac Dysfunction After Myocardial Infarction by Stephan, Jonah, Gu, Zhen, Taylor, Zoubul, Dassanayaka, Sujith, Brainard, Robert, Jones, Steven P, Wysoczynski, Marcin

“…Patient studies show that chitinase 3-like 1 (CHI3L1) is a novel biomarker of coronary artery disease (CAD). Furthermore, CHI3L1 plasma level is a strong…”
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Abstract 14268: PKM2 to PKM1 Isoform Switching in Fibroblasts Attenuates Cardiac Dysfunction in Infarcted Mice by McNally, Lindsey A, Mehra, Parul, Gibb, Andrew, Brittian, Kenneth, Gumpert, Anna, Dassanayaka, Sujith, Jones, Steven P, Hill, Bradford G

“…IntroductionThe muscle isoform of pyruvate kinase, PKM, has two splice variants, with PKM2 having important roles in cardiomyocytes during development. The…”
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E2F1 Transcription Factor Regulates O-linked N-acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Expression by Muthusamy, Senthilkumar, Hong, Kyung U., Dassanayaka, Sujith, Hamid, Tariq, Jones, Steven P.

“…Protein O-GlcNAcylation, which is controlled by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), has emerged as an important posttranslational modification…”
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MicroRNA-539 Is Up-regulated in Failing Heart, and Suppresses O-GlcNAcase Expression by Muthusamy, Senthilkumar, DeMartino, Angelica M., Watson, Lewis J., Brittian, Kenneth R., Zafir, Ayesha, Dassanayaka, Sujith, Hong, Kyung U., Jones, Steven P.

“…Derangements in metabolism and related signaling pathways characterize the failing heart. One such signal, O-linked β-N-acetylglucosamine (O-GlcNAc), is an…”
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Abstract 823: The Extracellular Matrix Component, Hyaluronan, Provokes a Pro-Inflammatory Phenotype in Macrophages by Audam, Timothy N, Dassanayaka, Sujith, Jurkovic, Andrea, Long, Bethany, Brittian, Kenneth R, Wysoczynski, Marcin, Jones, Steven P

“…Abstract only Background: The extracellular matrix (ECM) provides structural and functional support for the myocardium, but myocardial infarction (MI) changes…”
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Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction by Zelko, Igor N, Dassanayaka, Sujith, Malovichko, Marina V, Howard, Caitlin M, Garrett, Lauren F, Uchida, Shizuka, Brittian, Kenneth R, Conklin, Daniel J, Jones, Steven P, Srivastava, Sanjay

“…Abstract Benzene is a ubiquitous environmental pollutant abundant in household products, petrochemicals, and cigarette smoke. Benzene is a well-known…”
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Mechanistic Pathway(s) of Acquired Von Willebrand Syndrome with a Continuous-Flow Ventricular Assist Device: In Vitro Findings by Dassanayaka, Sujith, Slaughter, Mark S, Bartoli, Carlo R

“…In patients with a ventricular assist device (VAD), diminished high-molecular-weight von Willebrand factor (vWF) multimers may contribute to a bleeding…”
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Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload by Audam, Timothy N, Howard, Caitlin M, Garrett, Lauren F, Zheng, Yi Wei, Bradley, James A, Brittian, Kenneth R, Frank, Matthew W, Fulghum, Kyle L, Pólos, Miklós, Herczeg, Szilvia, Merkely, Béla, Radovits, Tamás, Uchida, Shizuka, Hill, Bradford G, Dassanayaka, Sujith, Jackowski, Suzanne, Jones, Steven P

“…Coenzyme A (CoA) is an essential cofactor required for intermediary metabolism. Perturbations in homeostasis of CoA have been implicated in various…”
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E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation by Dassanayaka, Sujith, Brittian, Kenneth R., Jurkovic, Andrea, Higgins, Lauren A., Audam, Timothy N., Long, Bethany W., Harrison, Linda T., Militello, Giuseppe, Riggs, Daniel W., Chitre, Mitali G., Uchida, Shizuka, Muthusamy, Senthilkumar, Gumpert, Anna M., Jones, Steven P.

“…Several post-translational modifications figure prominently in ventricular remodeling. The beta- O -linkage of N -acetylglucosamine ( O -GlcNAc) to proteins…”
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