Search Results - "DASER, Angelika"

Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis by Daser, Angelika, Rabbitts, Terence H

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Limiting dilution bisulfite (pyro)sequencing reveals parent-specific methylation patterns in single early mouse embryos and bovine oocytes by El Hajj, Nady, Trapphoff, Tom, Linke, Matthias, May, Andreas, Hansmann, Tamara, Kuhtz, Juliane, Reifenberg, Kurt, Heinzmann, Julia, Niemann, Heiner, Daser, Angelika, Eichenlaub-Ritter, Ursula, Zechner, Ulrich, Haaf, Thomas

“…To detect rare epigenetic effects associated with assisted reproduction, it is necessary to monitor methylation patterns of developmentally important genes in…”
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Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis by Drynan, Lesley F, Pannell, Richard, Forster, Alan, Chan, Nicole MM, Cano, Florencia, Daser, Angelika, Rabbitts, Terence H

“…Chromosomal translocations are primary events in tumorigenesis. Those involving the mixed lineage leukaemia (MLL) gene are found in various guises and it is…”
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Spontaneous B cell hyperactivity in autoimmune-prone MRL mice by Nijnik, Anastasia, Ferry, Helen, Lewis, Graham, Rapsomaniki, Eleni, Leung, Janson C. H., Daser, Angelika, Lambe, Teresa, Goodnow, Christopher C., Cornall, Richard J.

“…The MRL-lpr/lpr mouse strain is a commonly used model of the human autoimmune disease systemic lupus erythematosus (SLE). Although much is known about the…”
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The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells by Codrington, Rosalind, Pannell, Richard, Forster, Alan, Drynan, Lesley F, Daser, Angelika, Lobato, Nati, Metzler, Markus, Rabbitts, Terence H

“…The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an…”
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The invertor knock-in conditional chromosomal translocation mimic by Rabbitts, Terence H, Forster, Alan, Pannell, Richard, Drynan, Lesley F, Codrington, Rosalind, Daser, Angelika, Metzler, Markus, Lobato, M Natividad

“…Knock-in models of tumor-specific chromosomal translocations can generate lethal mutations. To circumvent this, a new conditional gene fusion model has been…”
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Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation by Neuhaus-Steinmetz, U, Glaab, T, Daser, A, Braun, A, Lommatzsch, M, Herz, U, Kips, J, Alarie, Y, Renz, H

“…Mouse models have been established mirroring key features of human bronchial asthma including airway hyperresponsiveness (AHR). Acute airway obstruction in…”
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Panel of microsatellite markers for whole-genome scans and radiation hybrid mapping and a mouse family tree by Schalkwyk, L C, Jung, M, Daser, A, Weiher, M, Walter, J, Himmelbauer, H, Lehrach, H

“…To facilitate whole-genome scan experiments, we selected a panel of 128 microsatellite markers on the basis of spacing and polymorphism in the strains DBA/2,…”
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Quantitative assessment of immediate cutaneous hypersensitivity in a model of genetic predisposition to atopy by Daser, A, Bätjer, N, Kölsch, U, Kötz, K, Schmeling, H, Schou, C, Renz, H

“…Genetic predisposition and environmental factors modulate the expression of allergic phenotypes. The frequent allergic phenotype 'immediate cutaneous…”
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Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription by Ali, Hanif, Daser, Angelika, Dear, Paul, Wood, Henry, Rabbitts, Pamela, Rabbitts, Terence

“…Chromosomal translocations and other abnormalities are central to the initiation of cancer in all cell types. Understanding the mechanism is therefore…”
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Homozygous disruption of PDZD7 by reciprocal translocation in a consanguineous family: a new member of the Usher syndrome protein interactome causing congenital hearing impairment by Schneider, Eberhard, Märker, Tina, Daser, Angelika, Frey-Mahn, Gabriele, Beyer, Vera, Farcas, Ruxandra, Schneider-Rätzke, Brigitte, Kohlschmidt, Nicolai, Grossmann, Bärbel, Bauss, Katharina, Napiontek, Ulrike, Keilmann, Annerose, Bartsch, Oliver, Zechner, Ulrich, Wolfrum, Uwe, Haaf, Thomas

“…A homozygous reciprocal translocation, 46,XY,t(10;11),t(10;11), was detected in a boy with non-syndromic congenital sensorineural hearing impairment. Both…”
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Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer by Forster, Alan, Pannell, Richard, Drynan, Lesley F, McCormack, Matthew, Collins, Emma C, Daser, Angelika, Rabbitts, Terence H

“…The etiology of human tumors often involves chromosomal translocations. Models that emulate translocations are essential to understanding the determinants of…”
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Differences in DNA Methylation Patterns and Expression of the CCRK Gene in Human and Nonhuman Primate Cortices by Farcas, Ruxandra, Schneider, Eberhard, Frauenknecht, Katrin, Kondova, Ivanela, Bontrop, Ronald, Bohl, Jürgen, Navarro, Bianca, Metzler, Markus, Zischler, Hans, Zechner, Ulrich, Daser, Angelika, Haaf, Thomas

“…Changes in DNA methylation patterns during embryo development and differentiation processes are linked to the transcriptional plasticity of our genome…”
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Interrogation of genomes by molecular copy-number counting (MCC) by Daser, Angelika, Thangavelu, Madan, Pannell, Richard, Forster, Alan, Sparrow, Louise, Chung, Grace, Dear, Paul H, Rabbitts, Terence H

“…Human cancers and some congenital traits are characterized by cytogenetic aberrations including translocations, amplifications, duplications or deletions that…”
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Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice by Glaab, T, Daser, A, Braun, A, Neuhaus-Steinmetz, U, Fabel, H, Alarie, Y, Renz, H

“…A method for the noninvasive measurement of airway responsiveness was validated in allergic BALB/c mice. With head-out body plethysmography and the decrease in…”
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De novo t(12;17)(p13.3;q21.3) translocation with a breakpoint near the 5' end of the HOXB gene cluster in a patient with developmental delay and skeletal malformations by YING YUE, FARCAS, Ruxandra, HAAF, Thomas, THIEL, Gundula, BOMMER, Christiane, GROSSMANN, Bärbel, GALETZKA, Danuta, KELBOVA, Christina, KÜPFERLING, Peter, DASER, Angelika, ZECHNER, Ulrich

“…A boy with severe mental retardation, funnel chest, bell-shaped thorax, and hexadactyly of both feet was found to have a balanced de novo t(12;17)(p13.3;q21.3)…”
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Mouse models for the genetic dissection of atopy by Heinzmann, Andrea, Daser, Angelika

“…Atopic disorders are complex traits with a significant contribution of heritability. Several mouse models for atopic phenotypes such as allergen-induced and…”
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Erratum: Corrigendum: Interrogation of genomes by molecular copy-number counting (MCC) by Daser, Angelika, Thangavelu, Madan, Pannell, Richard, Forster, Alan, Sparrow, Louise, Chung, Grace, Dear, Paul H, Rabbitts, Terence H

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Corrigendum: Interrogation of genomes by molecular copy-number counting by Daser, Angelika, Thangavelu, Madan, Pannell, Richard, Forster, Alan, Sparrow, Louise, Chung, Grace, Dear, Paul H, Rabbitts, Terence H

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Molecular Dynamics Simulation of MHC-Peptide Complexes as a Tool for Predicting Potential T Cell Epitopes by Rognan, Didier, Scapozza, Leonardo, Folkers, Gerd, Daser, Angelika

“…The class I major histocompatibility complex-encoded HLA-B*2705 protein was simulated in complex with six different peptides exhibiting unexpected…”
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