Search Results - "DARSHI, MANJULA"

The Warburg Effect in Diabetic Kidney Disease by Zhang, Guanshi, Darshi, Manjula, Sharma, Kumar

“…Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in diabetic patients. Defining risk factors for DKD using a reductionist approach…”
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A role for tubular Na + /H + exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin by Onishi, Akira, Fu, Yiling, Patel, Rohit, Darshi, Manjula, Crespo-Masip, Maria, Huang, Winnie, Song, Panai, Freeman, Brent, Kim, Young Chul, Soleimani, Manoocher, Sharma, Kumar, Thomson, Scott Culver, Vallon, Volker

“…Inhibitors of proximal tubular Na -glucose cotransporter 2 (SGLT2) are natriuretic, and they lower blood pressure. There are reports that the activities of…”
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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight by Garrett-Bakelman, Francine E, Darshi, Manjula, Green, Stefan J, Gur, Ruben C, Lin, Ling, Macias, Brandon R, McKenna, Miles J, Meydan, Cem, Mishra, Tejaswini, Nasrini, Jad, Piening, Brian D, Rizzardi, Lindsay F, Sharma, Kumar, Siamwala, Jamila H, Taylor, Lynn, Vitaterna, Martha Hotz, Afkarian, Maryam, Afshinnekoo, Ebrahim, Ahadi, Sara, Ambati, Aditya, Arya, Maneesh, Bezdan, Daniela, Callahan, Colin M, Chen, Songjie, Choi, Augustine M K, Chlipala, George E, Contrepois, Kévin, Covington, Marisa, Crucian, Brian E, De Vivo, Immaculata, Dinges, David F, Ebert, Douglas J, Feinberg, Jason I, Gandara, Jorge A, George, Kerry A, Goutsias, John, Grills, George S, Hargens, Alan R, Heer, Martina, Hillary, Ryan P, Hoofnagle, Andrew N, Hook, Vivian Y H, Jenkinson, Garrett, Jiang, Peng, Keshavarzian, Ali, Laurie, Steven S, Lee-McMullen, Brittany, Lumpkins, Sarah B, MacKay, Matthew, Maienschein-Cline, Mark G, Melnick, Ari M, Moore, Tyler M, Nakahira, Kiichi, Patel, Hemal H, Pietrzyk, Robert, Rao, Varsha, Saito, Rintaro, Salins, Denis N, Schilling, Jan M, Sears, Dorothy D, Sheridan, Caroline K, Stenger, Michael B, Tryggvadottir, Rakel, Urban, Alexander E, Vaisar, Tomas, Van Espen, Benjamin, Zhang, Jing, Ziegler, Michael G, Zwart, Sara R, Charles, John B, Kundrot, Craig E, Scott, Graham B I, Bailey, Susan M, Basner, Mathias, Feinberg, Andrew P, Lee, Stuart M C, Mason, Christopher E, Mignot, Emmanuel, Rana, Brinda K, Smith, Scott M, Snyder, Michael P, Turek, Fred W

“…To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the…”
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Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer by Darshi, Manjula, Van Espen, Benjamin, Sharma, Kumar

“…The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers…”
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Effect of renal tubule-specific knockdown of the Na + /H + exchanger NHE3 in Akita diabetic mice by Onishi, Akira, Fu, Yiling, Darshi, Manjula, Crespo-Masip, Maria, Huang, Winnie, Song, Panai, Patel, Rohit, Kim, Young Chul, Nespoux, Josselin, Freeman, Brent, Soleimani, Manoocher, Thomson, Scott, Sharma, Kumar, Vallon, Volker

“…Na /H exchanger isoform 3 (NHE3) contributes to Na /bicarbonate reabsorption and ammonium secretion in early proximal tubules. To determine its role in the…”
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ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function by Darshi, Manjula, Mendiola, Vincent L., Mackey, Mason R., Murphy, Anne N., Koller, Antonius, Perkins, Guy A., Ellisman, Mark H., Taylor, Susan S.

“…The mitochondrial inner membrane (IM) serves as the site for ATP production by hosting the oxidative phosphorylation complex machinery most notably on the…”
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Uniform nomenclature for the mitochondrial contact site and cristae organizing system by Pfanner, Nikolaus, van der Laan, Martin, Amati, Paolo, Capaldi, Roderick A, Caudy, Amy A, Chacinska, Agnieszka, Darshi, Manjula, Deckers, Markus, Hoppins, Suzanne, Icho, Tateo, Jakobs, Stefan, Ji, Jianguo, Kozjak-Pavlovic, Vera, Meisinger, Chris, Odgren, Paul R, Park, Sang Ki, Rehling, Peter, Reichert, Andreas S, Sheikh, M Saeed, Taylor, Susan S, Tsuchida, Nobuo, van der Bliek, Alexander M, van der Klei, Ida J, Weissman, Jonathan S, Westermann, Benedikt, Zha, Jiping, Neupert, Walter, Nunnari, Jodi

“…The mitochondrial inner membrane contains a large protein complex that functions in inner membrane organization and formation of membrane contact sites. The…”
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Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients by Hallan, Stein, Afkarian, Maryam, Zelnick, Leila R., Kestenbaum, Bryan, Sharma, Shoba, Saito, Rintaro, Darshi, Manjula, Barding, Gregory, Raftery, Daniel, Ju, Wenjun, Kretzler, Matthias, Sharma, Kumar, de Boer, Ian H.

“…Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly…”
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Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50 by Sastri, Mira, Darshi, Manjula, Mackey, Mason, Ramachandra, Ranjan, Ju, Saeyeon, Phan, Sebastien, Adams, Stephen, Stein, Kathryn, Douglas, Christopher R, Kim, Jiwan John, Ellisman, Mark H, Taylor, Susan S, Perkins, Guy A

“…Each mitochondrial compartment contains varying protein compositions that underlie a diversity of localized functions. Insights into the localization of…”
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Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator by Miyamoto, Satoshi, Hsu, Cheng-Chih, Hamm, Gregory, Darshi, Manjula, Diamond-Stanic, Maggie, Declèves, Anne-Emilie, Slater, Larkin, Pennathur, Subramaniam, Stauber, Jonathan, Dorrestein, Pieter C., Sharma, Kumar

“…AMP-activated protein kinase (AMPK) is suppressed in diabetes and may be due to a high ATP/AMP ratio, however the quantitation of nucleotides in vivo has been…”
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Crabtree effect in kidney proximal tubule cells via late-stage glycolytic intermediates by Darshi, Manjula, Tumova, Jana, Saliba, Afaf, Kim, Jiwan, Baek, Judy, Pennathur, Subramaniam, Sharma, Kumar

“…The Crabtree effect is defined as a rapid glucose-induced repression of mitochondrial oxidative metabolism and has been described in yeasts and tumor cells…”
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Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications by Sas, Kelli M, Kayampilly, Pradeep, Byun, Jaeman, Nair, Viji, Hinder, Lucy M, Hur, Junguk, Zhang, Hongyu, Lin, Chengmao, Qi, Nathan R, Michailidis, George, Groop, Per-Henrik, Nelson, Robert G, Darshi, Manjula, Sharma, Kumar, Schelling, Jeffrey R, Sedor, John R, Pop-Busui, Rodica, Weinberg, Joel M, Soleimanpour, Scott A, Abcouwer, Steven F, Gardner, Thomas W, Burant, Charles F, Feldman, Eva L, Kretzler, Matthias, Brosius, 3rd, Frank C, Pennathur, Subramaniam

“…Diabetes is associated with altered cellular metabolism, but how altered metabolism contributes to the development of diabetic complications is unknown. We…”
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Quantitative Proteomic and Functional Analysis of Liver Mitochondria from High Fat Diet (HFD) Diabetic Mice by Guo, Yurong, Darshi, Manjula, Ma, Yuliang, Perkins, Guy A., Shen, Zhouxin, Haushalter, Kristofer J., Saito, Rintaro, Chen, Ai, Lee, Yun Sok, Patel, Hemal H., Briggs, Steven P., Ellisman, Mark H., Olefsky, Jerrold M., Taylor, Susan S.

“…Insulin resistance plays a major role in the development of type 2 diabetes and obesity and affects a number of biological processes such as mitochondrial…”
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Gut Microbial Changes in Diabetic db/db Mice and Recovery of Microbial Diversity upon Pirfenidone Treatment by Singh, Harinder, Miyamoto, Satoshi, Darshi, Manjula, Torralba, Manolito G., Kwon, Keehwan, Sharma, Kumar, Pieper, Rembert

“…The leptin receptor-deficient db/db mouse model is an accepted in vivo model to study obesity, type 2 diabetes, and diabetic kidney disease. Healthy…”
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Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system by Keshwani, Malik M., Kanter, Joan R., Ma, Yuliang, Wilderman, Andrea, Darshi, Manjula, Insel, Paul A., Taylor, Susan S.

“…Cyclic AMP/protein kinase A (cAMP/PKA) and glucocorticoids promote the death of many cell types, including cells of hematopoietic origin. In wild-type (WT) S49…”
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kinase interacting protein (AKIP1) is a key regulator of cardiac stress by Sastri, Mira, Haushalter, Kristofer J, Panneerselvam, Mathivadhani, Chang, Philip, Fridolfsson, Heidi, Finley, J Cameron, Ng, Daniel, Schilling, Jan M, Miyanohara, Atsushi, Day, Michele E, Hakozaki, Hiro, Petrosyan, Susanna, Koller, Antonius, King, Charles C, Darshi, Manjula, Blumenthal, Donald K, Ali, Sameh Saad, Roth, David M, Patel, Hemal H, Taylor, Susan S

“…Significance Early signaling events leading to protection in the heart under cardiac injury are poorly understood. We identified one such protein, A kinase…”
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Identification of ChChd3 as a Novel Substrate of the cAMP-dependent Protein Kinase (PKA) Using an Analog-sensitive Catalytic Subunit by Schauble, Sharmin, King, Charles C., Darshi, Manjula, Koller, Antonius, Shah, Kavita, Taylor, Susan S.

“…Due to the numerous kinases in the cell, many with overlapping substrates, it is difficult to find novel substrates for a specific kinase. To identify novel…”
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Identification of Circulating Metabolites to Predict Cardiorenal Outcomes in Patients with Type 2 Diabetes (T2D): TH-PO174 by Hansen, Michael K., Darshi, Manjula, Kohler, Kristen, Tang, Owen, Figtree, Gemma

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Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes by Mulder, Skander, Heerspink, Hiddo J. L., Darshi, Manjula, Kim, Jiwan J., Laverman, Gozewijn D., Sharma, Kumar, Pena, Michelle J.

“…Aim To assess the effects of the sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor dapagliflozin on a pre‐specified panel of 13 urinary metabolites linked to…”
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Metabolomic Markers of Kidney Function Decline in Patients With Diabetes: Evidence From the Chronic Renal Insufficiency Cohort (CRIC) Study by Kwan, Brian, Fuhrer, Tobias, Zhang, Jing, Darshi, Manjula, Van Espen, Benjamin, Montemayor, Daniel, de Boer, Ian H., Dobre, Mirela, Hsu, Chi-yuan, Kelly, Tanika N., Raj, Dominic S., Rao, Panduranga S., Saraf, Santosh L., Scialla, Julia, Waikar, Sushrut S., Sharma, Kumar, Natarajan, Loki, Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Lash, James P., Rahman, Mahboob, Townsend, Raymond R.

“…Biomarkers that provide reliable evidence of future diabetic kidney disease (DKD) are needed to improve disease management. In a cross-sectional study, we…”
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