Search Results - "DARMON, A. J"

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B by Darmon, Alison J, Nicholson, Donald W, Bleackley, R. Chris

“…Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity represents the body's major defence against virus-infected and tumorigenic cells, and contributes to…”
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The cytotoxic T cell proteinase granzyme B does not activate interleukin-1 beta-converting enzyme by Darmon, A J, Ehrman, N, Caputo, A, Fujinaga, J, Bleackley, R C

“…Murine granzyme B (cytotoxic cell proteinase-1 (CCP1)) is a member of a family of seven serine proteases found in cytoplasmic granules of cytotoxic T…”
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Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen by POWELL, A. J, DARMON, A. J, GONOS, E. S, LAM, E. W.-F, PEDEN, K. W. C, JAT, P. S

“…We have used two different, but complementary assays to characterize functions of SV40 T antigen that are necessary for its ability to immortalize rat embryo…”
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Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B by Atkinson, E A, Barry, M, Darmon, A J, Shostak, I, Turner, P C, Moyer, R W, Bleackley, R C

“…Cytototoxic T lymphocyte-induced apoptosis can occur either through the directed exocytosis of granzyme B and perforin or via ligation of Fas. Both pathways…”
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Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation by Darmon, A J, Ley, T J, Nicholson, D W, Bleackley, R C

“…Cytotoxic T lymphocytes (CTLs) are able to recognize and destroy target cells bearing foreign antigen using one of two distinct mechanisms: granule- or…”
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An Interleukin-1β Converting Enzyme-like Protease Is a Key Component of Fas-mediated Apoptosis by Darmon, Alison J., Bleackley, R. Chris

“…Cytotoxic T lymphocytes (CTLs) are able to kill target cells bearing foreign antigen through two distinct mechanisms: granule- and Fas-mediated cytotoxicity…”
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L is for lytic granules: lysosomes that kill by Page, Lesley J, Darmon, Alison J, Uellner, Ruth, Griffiths, Gillian M

“…CTL are important cells in the immune system which are able to recognise and directly destroy virally infected, tumorigenic or foreign cells. The proteins…”
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Proteases and cell-mediated cytotoxicity by Darmon, A J, Bleackley, R C

“…Cytotoxic T lymphocytes and natural killer cells represent the body's primary defense against viral-infected and tumorigenic cells. The classically described…”
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Granule-mediated cytotoxicity by Darmon, A J, Pinkoski, M J, Bleackley, R C

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Ca super(2+)-dependent Localization of Integrin-linked Kinase to Cell Junctions in Differentiating Keratinocytes by Vespa, A, Darmon, A J, Turner, CE, D'Souza, SJA, Dagnino, L

“…Integrin complexes are necessary for proper proliferation and differentiation of epidermal keratinocytes. Differentiation of these cells is accompanied by…”
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An interleukin-1beta converting enzyme-like protease is a key component of Fas-mediated apoptosis by Darmon, A J, Bleackley, R C

“…Cytotoxic T lymphocytes (CTLs) are able to kill target cells bearing foreign antigen through two distinct mechanisms: granule- and Fas-mediated cytotoxicity…”
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Apoptosis in murine hepatoma hepa 1c1c7 wild-type, C12, and C4 cells mediated by bilirubin by Seubert, John M, Darmon, Alison J, El-Kadi, Ayman O S, D'Souza, Sudhir J A, Bend, John R

“…Elevated serum and tissue bilirubin concentrations that occur in pathological conditions such as cholestasis, jaundice, and other liver diseases are known to…”
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Ca2+-dependent Localization of Integrin-linked Kinase to Cell Junctions in Differentiating Keratinocytes by Vespa, Alisa, Darmon, Alison J, Turner, Christopher E, D'Souza, Sudhir J A, Dagnino, Lina

“…Integrin complexes are necessary for proper proliferation and differentiation of epidermal keratinocytes. Differentiation of these cells is accompanied by…”
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BAP37 and Prohibitin Are Specifically Recognized by an SV40 T Antigen Antibody by Darmon, Alison J., Jat, Parmjit S.

“…We have identified two cellular proteins that are specifically immunoprecipitated by an anti-SV40 T antigen monoclonal antibody. This antibody, PAb419,…”
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Delayed apoptosis post-cadmium injury in renal proximal tubule epithelial cells by Stinson, Lindsay J, Darmon, Alison J, Dagnino, Lina, D'Souza, S J A

“…Accumulation of the widespread environmental toxin cadmium (Cd) in the kidney results initially in proximal tubule dysfunction. Exposure to Cd has been…”
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