Search Results - "DANKS, M. K"

Stem and progenitor cell-mediated tumor selective gene therapy by Aboody, K S, Najbauer, J, Danks, M K

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Stem and progenitor cell-mediated tumor selective gene therapy by Aboody, K S, Najbauer, J, Danks, M K

“…The poor prognosis for patients with aggressive or metastatic tumors and the toxic side effects of currently available treatments necessitate the development…”
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Proficient metabolism of irinotecan by a human intestinal carboxylesterase by KHANNA, Ruchi, MORTON, Christopher L, DANKS, Mary K, POTTER, Philip M

“…Irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)] is metabolized by esterases to yield the potent topoisomerase I poison…”
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Activation of CPT-11 in mice : Identification and analysis of a highly effective plasma esterase by MORTON, C. L, WIERDL, M, OLIVER, L, MA, M. K, DANKS, M. K, STEWART, C. F, EISEMAN, J. L, POTTER, P. M

“…The camptothecin prodrug CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is converted by esterases to yield the potent…”
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Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors by HOUGHTON, P. J, CHESHIRE, P. J, HALLMAN, J. D, LUTZ, L, FRIEDMAN, H. S, DANKS, M. K, HOUGHTON, J. A

“…The efficacy of protracted schedules of therapy of the topoisomerase I inhibitors 9-dimethyl-aminomethyl-10-hydroxycamptothecin (topotecan) and…”
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The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase by MORTON, C. L, WADKINS, R. M, DANKS, M. K, POTTER, P. M

“…Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for…”
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Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase by WIERDL, Monika, MORTON, Christopher L, WEEKS, James K, DANKS, Mary K, HARRIS, Linda C, POTTER, Philip M

“…Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) is activated by carboxylesterases (CE) to yield the potent topoisomerase…”
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Comparison of Activation of CPT-11 by Rabbit and Human Carboxylesterases for Use in Enzyme/Prodrug Therapy by DANKS, M. K, MORTON, C. L, KRULL, E. J, CHESHIRE, P. J, RICHMOND, L. B, NAEVE, C. W, PAWLIK, C. A, HOUGHTON, P. J, POTTER, P. M

“…Several recent studies have examined the possibility of producing tumor-specific cytotoxicity with various enzyme/prodrug combinations. The enzymes are…”
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Expression of a Mutant DNA Topoisomerase II in CCRF-CEM Human Leukemic Cells Selected for Resistance to Teniposide by BUGG, B. Y, DANKS, M. K, BECK, W. T, PARKER SUTTLE, D

“…Nuclear extracts from teniposide (VM-26)-resistant sublines of the human leukemic cell line CCRF-CEM have decreased levels of DNA topoisomerase II catalytic…”
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Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11) by POTTER, P. M, PAWLIK, C. A, MORTON, C. L, NAEVE, C. W, DANKS, M. K

“…We have isolated a cDNA encoding a rabbit carboxylesterase (CE; EC 3.1.1.1) that converts the camptothecin-derived prodrug irinotecan (CPT-11) to the potent…”
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Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11 by DANKS, M. K, MORTON, C. L, PAWLIK, C. A, POTTER, P. M

“…CPT-11 [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin ] is a prodrug that is converted to the active metabolite SN-38 by carboxylesterases…”
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Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase by GUICHARD, S. M, MORTON, C. L, KRULL, E. J, STEWART, C. F, DANKS, M. K, POTTER, P. M

“…The anticancer drug CPT-11 (7-ethyl-[4(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is a water-soluble derivative of camptothecin. We report here the…”
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Cellular localization domains of a rabbit and a human carboxylesterase : Influence on irinotecan (CPT-11) metabolism by the rabbit enzyme by POTTER, P. M, WOLVERTON, J. S, MORTON, C. L, WIERDL, M, DANKS, M. K

“…Enzyme activation of prodrugs to improve the therapeutic index of specific anticancer agents is an attractive alternative to current chemotherapy regimens…”
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Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays by PAWLIK, C. A, HOUGHTON, P. J, STEWART, C. F, CHESHIRE, P. J, RICHMOND, L. B, DANKS, M. K

“…The camptothecin derivative topotecan has been postulated to mediate its antitumor effect through a drug-induced increase in covalent topoisomerase I-DNA…”
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A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11 by MECK, Mandy M, WIERDL, Monika, WAGNER, Lars M, BURGER, Rebecca A, GUICHARD, Sylvie M, KRULL, Erik J, HARRIS, Linda C, POTTER, Philip M, DANKS, Mary K

“…Tumor cells that contaminate hematopoietic cell preparations contribute to the relapse of neuroblastoma patients who receive autologous stem cell rescue as a…”
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Intermittent exposure of medulloblastoma cells to topotecan produces growth inhibition equivalent to continuous exposure by DANKS, M. K, PAWLIK, C. A, WHIPPLE, D. O, WOLVERTON, J. S

“…Camptothecin analogues such as topotecan increase the number of covalent topoisomerase I-DNA complexes, which, in turn, have been proposed to initiate…”
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Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan by DANKS, M. K, GARRETT, K. E, MARION, R. C, WHIPPLE, D. O

“…DNA topoisomerase I is the cytotoxic target for chemotherapeutic agents of the camptothecin class. The cytotoxicity of these drugs is thought to be mediated by…”
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A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuraxis in the nonhuman primate model: implications for treatment of children with metastatic medulloblastoma by ZAMBONI, W. C, GAJJAR, A. J, MANDRELL, T. D, EINHAUS, S. L, DANKS, M. K, ROGERS, W. P, HEIDEMAN, R. L, HOUGHTON, P. J, STEWART, C. F

“…The purpose of this study was to define the length of topotecan (TPT) i.v. infusion necessary to attain a cytotoxic exposure for medulloblastoma cells…”
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Decreased drug accumulation in a mitoxantrone‐resistant gastric carcinoma cell line in the absence of P‐glycoprotein by Kellner, Udo, Hutchinson, Lesley, Seidel, André, Lage, Hermann, Danks, Mary K., Dietel, Manfred, Kaufmann, Scott H.

“…An established gastric‐carcinoma cell line, EPG85‐257P, is extremely sensitive to mitoxantrone (IC50, 0.12 ng/ml). Stepwise selection with mitoxantrone for 3…”
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Identification and Characterization of Novel Benzil (Diphenylethane-1,2-dione) Analogues as Inhibitors of Mammalian Carboxylesterases by Wadkins, Randy M, Hyatt, Janice L, Wei, Xin, Yoon, Kyoung Jin P, Wierdl, Monika, Edwards, Carol C, Morton, Christopher L, Obenauer, John C, Damodaran, Komath, Beroza, Paul, Danks, Mary K, Potter, Philip M

“…Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of…”
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