Prevalence of blood-borne viral infections (cytomegalovirus, human herpesvirus-6, human herpesvirus-7, human herpesvirus-8, human T-cell lymphotropic virus-I/II, human retrovirus-5) among blood donors in Latvia

The identification of blood-borne viral infections is important in transfusion medicine. The aim of this study was to evaluate the prevalence of human herpesvirus (HHV) [cytomegalovirus (CMV), HHV-6, HHV-7 HHV-8] and human retrovirus (HRV) (human T-cell lymphotropic virus (HTLV)-I/II, HRV-5) infecti...

Full description

Saved in:

Bibliographic Details
Published in:	Annals of hematology Vol. 80; no. 11; pp. 669 - 673
Main Authors:	KOZIREVA, S, NEMCEVA, G, DANILANE, I, PAVLOVA, O, BLOMBERG, J, MUROVSKA, M
Format:	Journal Article
Language:	English
Published:	Berlin Springer 01-11-2001 Springer Nature B.V
Subjects:	Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - blood Blood - virology Blood Donors Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Cytomegalovirus Cytomegalovirus Infections - blood Cytomegalovirus Infections - virology DNA, Viral - analysis Female Herpesviridae Infections - blood Herpesviridae Infections - virology Herpesvirus 6, Human - genetics Herpesvirus 6, Human - isolation & purification Herpesvirus 7, Human - genetics Herpesvirus 7, Human - isolation & purification Herpesvirus 8, Human - genetics Herpesvirus 8, Human - isolation & purification HTLV-I Infections - blood HTLV-I Infections - virology HTLV-II Infections - blood HTLV-II Infections - virology Human cytomegalovirus Human herpesvirus 6 Human herpesvirus 7 Human herpesvirus 8 Human T-lymphotropic virus Human T-lymphotropic virus 1 Human T-lymphotropic virus 2 Human viral diseases Humans Infection Infectious diseases Latvia Leukocytes Lymphocytes T Male Medical sciences Middle Aged Peripheral blood Polymerase chain reaction Receptors, Interleukin-2 - blood Retroviridae Infections - blood Retroviridae Infections - virology Retrovirus Roseolovirus Infections - blood Roseolovirus Infections - virology Tax protein Transfusion Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Sweden Europe Latvia Human Cytomegalovirus Prevalence Transfusion Herpesviridae Retroviridae HTLV virus Betaherpesvirinae Epidemiology Infection Virus Polymerase chain reaction DNA Viral disease Molecular biology Blood donor
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The identification of blood-borne viral infections is important in transfusion medicine. The aim of this study was to evaluate the prevalence of human herpesvirus (HHV) [cytomegalovirus (CMV), HHV-6, HHV-7 HHV-8] and human retrovirus (HRV) (human T-cell lymphotropic virus (HTLV)-I/II, HRV-5) infections among apparently healthy Latvian blood donors. DNA extracted from peripheral blood leukocytes (PBL) of 150 individuals was tested for herpesviruses by sensitive polymerase chain reaction (PCR) technique. None of the blood donors was positive for HHV-8 infection, while the incidence of latent beta-herpesvirus infections was high: single infection by CMV, HHV-6, and HHV-7 was detected in 2.6%, 8.0%, and 43.3% of blood donors, respectively. Simultaneous dual and triple infections of these viruses were observed in 28.0% and 4.7% of individuals, respectively. Active infection by CMV and HHV-6 was not found, but HHV-7 DNA was present in plasma of 10.6% of the blood donors. While all blood donors were HTLV-II and HRV-5 negative, 4.6% of HTLV-I seronegative blood donors were positive for the HTLV-I tax gene, although none of them harbored sequences for structural genes of the provirus. Based on our results, we conclude that monitoring of beta-herpesvirus infections in blood donors can be important in cases of transfusions to immunocompromised persons. HHV-8, as well as the retroviruses HTLV-II and HRV-5, were not found in blood of Latvian blood donors. More investigations are required to explain the presence of the HTLV-I tax sequence in seronegative blood donors.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0939-5555 1432-0584
DOI:	10.1007/s002770100359