Search Results - "DANIELS, L"

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7 by Zoppi, Vittoria, Hughes, Scott J, Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M, Daniels, Danette L, Spallarossa, Andrea, Ciulli, Alessio

“…Developing PROTACs to redirect the ubiquitination activity of E3 ligases and potently degrade a target protein within cells can be a lengthy and unpredictable…”
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SP-0398: Active surveillance for cardiovascular disease after Hodgkins lymphoma by Daniels, L

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HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia by Galbraith, Matthew D., Allen, Mary A., Bensard, Claire L., Wang, Xiaoxing, Schwinn, Marie K., Qin, Bo, Long, Henry W., Daniels, Danette L., Hahn, William C., Dowell, Robin D., Espinosa, Joaquín M.

“…The transcription factor HIF1A is a key mediator of the cellular response to hypoxia. Despite the importance of HIF1A in homeostasis and various pathologies,…”
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Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations by Calderon, Christopher P, Daniels, Austin L, Randolph, Theodore W

“…Flow-imaging microscopy (FIM) is commonly used to characterize subvisible particles in therapeutic protein formulations. Although pharmaceutical companies…”
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Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation by Gilan, Omer, Rioja, Inmaculada, Knezevic, Kathy, Bell, Matthew J, Yeung, Miriam M, Harker, Nicola R, Lam, Enid Y N, Chung, Chun-Wa, Bamborough, Paul, Petretich, Massimo, Urh, Marjeta, Atkinson, Stephen J, Bassil, Anna K, Roberts, Emma J, Vassiliadis, Dane, Burr, Marian L, Preston, Alex G S, Wellaway, Christopher, Werner, Thilo, Gray, James R, Michon, Anne-Marie, Gobbetti, Thomas, Kumar, Vinod, Soden, Peter E, Haynes, Andrea, Vappiani, Johanna, Tough, David F, Taylor, Simon, Dawson, Sarah-Jane, Bantscheff, Marcus, Lindon, Matthew, Drewes, Gerard, Demont, Emmanuel H, Daniels, Danette L, Grandi, Paola, Prinjha, Rab K, Dawson, Mark A

“…The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins enable chromatin binding to facilitate transcription. Drugs that inhibit…”
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KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors by Black, Joshua C., Manning, Amity L., Van Rechem, Capucine, Kim, Jaegil, Ladd, Brendon, Cho, Juok, Pineda, Cristiana M., Murphy, Nancy, Daniels, Danette L., Montagna, Cristina, Lewis, Peter W., Glass, Kimberly, Allis, C. David, Dyson, Nicholas J., Getz, Gad, Whetstine, Johnathan R.

“…Acquired chromosomal instability and copy number alterations are hallmarks of cancer. Enzymes capable of promoting site-specific copy number changes have yet…”
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Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice by Knowlton, Wendy M, Daniels, Richard L, Palkar, Radhika, McCoy, Daniel D, McKemy, David D

“…TRPM8 (Transient Receptor Potential Melastatin-8) is a cold- and menthol-gated ion channel necessary for the detection of cold temperatures in the mammalian…”
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NanoBRETA Novel BRET Platform for the Analysis of Protein–Protein Interactions by Machleidt, Thomas, Woodroofe, Carolyn C, Schwinn, Marie K, Méndez, Jacqui, Robers, Matthew B, Zimmerman, Kris, Otto, Paul, Daniels, Danette L, Kirkland, Thomas A, Wood, Keith V

“…Dynamic interactions between proteins comprise a key mechanism for temporal control of cellular function and thus hold promise for development of novel drug…”
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The Feeding Practices and Structure Questionnaire: development and validation of age appropriate versions for infants and toddlers by Jansen, E, Russell, C G, Appleton, J, Byrne, R, Daniels, L A, Fowler, C, Rossiter, C, Mallan, K M

“…In order to measure and understand trajectories of parental feeding practices and their relationship with child eating and weight, it is desirable to perform…”
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Evidence for widespread changes in the structure, composition, and fire regimes of western North American forests by Hagmann, R. K., Hessburg, P. F., Prichard, S. J., Povak, N. A., Brown, P. M., Fulé, P. Z., Keane, R. E., Knapp, E. E., Lydersen, J. M., Metlen, K. L., Reilly, M. J., Meador, A. J. Sánchez, Stephens, S. L., Stevens, J. T., Taylor, A. H., Yocom, L. L., Battaglia, M. A., Churchill, D. J., Daniels, L. D., Falk, D. A., Henson, P., Johnston, J. D., Krawchuk, M. A., Levine, C. R., Meigs, G. W., Merschel, A. G., North, M. P., Safford, H. D., Swetnam, T. W., Waltz, A. E. M.

“…Implementation of wildfire- and climate-adaptation strategies in seasonally dry forests of western North America is impeded by numerous constraints and…”
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Chronic fatigue in Hodgkin lymphoma survivors and associations with anxiety, depression and comorbidity by Daniëls, L A, Oerlemans, S, Krol, A D G, Creutzberg, C L, van de Poll-Franse, L V

“…Background: Fatigue is a frequent and persistent problem among Hodgkin lymphoma (HL) survivors. We investigated the prevalence of clinically relevant fatigue…”
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Evaluation of an intervention to promote protective infant feeding practices to prevent childhood obesity: outcomes of the NOURISH RCT at 14 months of age and 6 months post the first of two intervention modules by Daniels, L A, Mallan, K M, Battistutta, D, Nicholson, J M, Perry, R, Magarey, A

“…Objective: To evaluate a universal obesity prevention intervention, which commenced at infant age 4–6 months, using outcome data assessed 6 months after…”
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TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS by Deplus, Rachel, Delatte, Benjamin, Schwinn, Marie K, Defrance, Matthieu, Méndez, Jacqui, Murphy, Nancy, Dawson, Mark A, Volkmar, Michael, Putmans, Pascale, Calonne, Emilie, Shih, Alan H, Levine, Ross L, Bernard, Olivier, Mercher, Thomas, Solary, Eric, Urh, Marjeta, Daniels, Danette L, Fuks, François

“…TET proteins convert 5‐methylcytosine to 5‐hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has…”
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Particulate Matter Exposure, Prenatal and Postnatal Windows of Susceptibility, and Autism Spectrum Disorders by Kalkbrenner, Amy E., Windham, Gayle C., Serre, Marc L., Akita, Yasuyuki, Wang, Xuexia, Hoffman, Kate, Thayer, Brian P., Daniels, Julie L.

“…BACKGROUND:Recent studies suggest that exposure to traffic-related air pollutants, including particulate matter (PM), is associated with autism spectrum…”
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Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy by Picaud, Sarah, Fedorov, Oleg, Thanasopoulou, Angeliki, Leonards, Katharina, Jones, Katherine, Meier, Julia, Olzscha, Heidi, Monteiro, Octovia, Martin, Sarah, Philpott, Martin, Tumber, Anthony, Filippakopoulos, Panagis, Yapp, Clarence, Wells, Christopher, Che, Ka Hing, Bannister, Andrew, Robson, Samuel, Kumar, Umesh, Parr, Nigel, Lee, Kevin, Lugo, Dave, Jeffrey, Philip, Taylor, Simon, Vecellio, Matteo L, Bountra, Chas, Brennan, Paul E, O'Mahony, Alison, Velichko, Sharlene, Müller, Susanne, Hay, Duncan, Daniels, Danette L, Urh, Marjeta, La Thangue, Nicholas B, Kouzarides, Tony, Prinjha, Rab, Schwaller, Jürg, Knapp, Stefan

“…The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth…”
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DORIC TEMPLE HBIM LIBRARY FOR CULTURAL HERITAGE MANAGEMENT by Daniels, L., Georgopoulos, A.

“…Heritage Building Information Modelling (HBIM) can be a valuable tool for the efficient management of cultural heritage. Adopting Building Information…”
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Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study by Doherty, Brett T., Hoffman, Kate, Keil, Alexander P., Engel, Stephanie M., Stapleton, Heather M., Goldman, Barbara D., Olshan, Andrew F., Daniels, Julie L.

“…Organophosphate esters (OPEs) are a class of chemicals commonly used as flame retardants and plasticizers. OPEs are applied to a wide variety of consumer…”
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Polyfluoroalkyl chemicals and menopause among women 20-65 years of age (NHANES) by Taylor, Kyla W, Hoffman, Kate, Thayer, Kristina A, Daniels, Julie L

“…Polyfluoroalkyl chemicals (PFCs) such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have been associated with early menopause. However,…”
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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor by Clark, Peter G. K., Vieira, Lucas C. C., Tallant, Cynthia, Fedorov, Oleg, Singleton, Dean C., Rogers, Catherine M., Monteiro, Octovia P., Bennett, James M., Baronio, Roberta, Müller, Susanne, Daniels, Danette L., Méndez, Jacqui, Knapp, Stefan, Brennan, Paul E., Dixon, Darren J.

“…The bromodomain‐containing proteins BRD9 and BRD7 are part of the human SWI/SNF chromatin‐remodeling complexes BAF and PBAF. To date, no selective inhibitor…”
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The TIP60 Complex Is a Conserved Coactivator of HIF1A by Perez-Perri, Joel I., Dengler, Veronica L., Audetat, K. Audrey, Pandey, Ahwan, Bonner, Elizabeth A., Urh, Marjeta, Mendez, Jacqui, Daniels, Danette L., Wappner, Pablo, Galbraith, Matthew D., Espinosa, Joaquín M.

“…Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous…”
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