Search Results - "DANG, Chi V"

MYC on the Path to Cancer by Dang, Chi V.

“…The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to therapeutic opportunities…”
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Links between metabolism and cancer by Dang, Chi V

“…Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated oncogenes and loss of tumor suppressors in turn alter metabolism and…”
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From Krebs to clinic: glutamine metabolism to cancer therapy by Altman, Brian J., Stine, Zachary E., Dang, Chi V.

“…Key Points Cancer cells show increased consumption of and dependence on glutamine. Glutamine metabolism fuels the tricarboxylic acid (TCA) cycle, nucleotide…”
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Targeting cancer metabolism in the era of precision oncology by Stine, Zachary E., Schug, Zachary T., Salvino, Joseph M., Dang, Chi V.

“…One hundred years have passed since Warburg discovered alterations in cancer metabolism, more than 70 years since Sidney Farber introduced anti-folates that…”
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Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells? by Dang, Chi V.

“…A cancer cell comprising largely of carbon, hydrogen, oxygen, phosphorus, nitrogen and sulfur requires not only glucose, which is avidly transported and…”
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Otto Warburg's contributions to current concepts of cancer metabolism by Koppenol, Willem H, Dang, Chi V, Bounds, Patricia L

“…Key Points Otto Warburg was a pioneering biochemistry researcher who made substantial contributions to our early understanding of cancer metabolism. Warburg…”
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MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities by Dang, Chi V, Le, Anne, Gao, Ping

“…Although cancers have altered glucose metabolism, termed the Warburg effect, which describes the increased uptake and conversion of glucose to lactate by…”
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The role of long noncoding RNAs in cancer: the dark matter matters by Hu, Xiaowen, Sood, Anil K, Dang, Chi V, Zhang, Lin

“…Sequencing technology has facilitated a new era of cancer research, especially in cancer genomics. Using next-generation sequencing, thousands of long…”
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MYC, Metabolism, and Cancer by Stine, Zachary E, Walton, Zandra E, Altman, Brian J, Hsieh, Annie L, Dang, Chi V

“…The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests…”
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Cancer's molecular sweet tooth and the warburg effect by KIM, Jung-Whan, DANG, Chi V

“…More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells avidly consume glucose and produce lactic acid under aerobic…”
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Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers by Yan, Xiaohui, Hu, Zhongyi, Feng, Yi, Hu, Xiaowen, Yuan, Jiao, Zhao, Sihai D., Zhang, Youyou, Yang, Lu, Shan, Weiwei, He, Qun, Fan, Lingling, Kandalaft, Lana E., Tanyi, Janos L., Li, Chunsheng, Yuan, Chao-Xing, Zhang, Dongmei, Yuan, Huiqing, Hua, Keqin, Lu, Yiling, Katsaros, Dionyssios, Huang, Qihong, Montone, Kathleen, Fan, Yi, Coukos, George, Boyd, Jeff, Sood, Anil K., Rebbeck, Timothy, Mills, Gordon B., Dang, Chi V., Zhang, Lin

“…The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA…”
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A Time for MYC: Metabolism and Therapy by Dang, Chi V

“…The MYC oncogene is frequently deregulated in human cancers, whereas the proto-oncogene is exquisitely, tightly regulated in normal cells. Deregulated MYC…”
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Control of TH17/Tᵣₑg Balance by Hypoxia-Inducible Factor 1 by Dang, Eric V, Barbi, Joseph, Yang, Huang-Yu, Jinasena, Dilini, Yu, Hong, Zheng, Ying, Bordman, Zachary, Fu, Juan, Kim, Young, Yen, Hung-Rong, Luo, Weibo, Zeller, Karen, Shimoda, Larissa, Topalian, Suzanne L, Semenza, Gregg L, Dang, Chi V, Pardoll, Drew M, Pan, Fan

“…T cell differentiation into distinct functional effector and inhibitory subsets is regulated, in part, by the cytokine environment present at the time of…”
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HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity by Zhang, Huafeng, Gao, Ping, Fukuda, Ryo, Kumar, Ganesh, Krishnamachary, Balaji, Zeller, Karen I., Dang, Chi V., Semenza, Gregg L.

“…Many cancer cells are characterized by increased glycolysis and decreased respiration, even under aerobic conditions. The molecular mechanisms underlying this…”
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Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer by Zhang, Youyou, He, Qun, Hu, Zhongyi, Feng, Yi, Fan, Lingling, Tang, Zhaoqing, Yuan, Jiao, Shan, Weiwei, Li, Chunsheng, Hu, Xiaowen, Tanyi, Janos L, Fan, Yi, Huang, Qihong, Montone, Kathleen, Dang, Chi V, Zhang, Lin

“…New data reveal that LINP1, a lncRNA overexpressed in triple-negative breast cancer, interacts with the Ku70–Ku80 complex and DNA-PKcs, thereby promoting…”
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A metabolic perspective of Peto's paradox and cancer by Dang, Chi V.

“…The frequency of cancer is postulated to be proportional to the number of cells an animal possesses, as each cell is similarly exposed to mutagens with every…”
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Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition by Yang, Lu, Zhang, Youyou, Shan, Weiwei, Hu, Zhongyi, Yuan, Jiao, Pi, Jingjiang, Wang, Yueying, Fan, Lingling, Tang, Zhaoqing, Li, Chunsheng, Hu, Xiaowen, Tanyi, Janos L, Fan, Yi, Huang, Qihong, Montone, Kathleen, Dang, Chi V, Zhang, Lin

“…Strategies to enhance response to poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi) in primary and acquired homologous recombination…”
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The interplay between MYC and HIF in cancer by Dang, Chi V, Kim, Jung-whan, Gao, Ping, Yustein, Jason

“…This Perspective considers the differences between the hypoxia-inducible factor (HIF)–MYC transcriptional network that operates under normal homeostatic…”
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR by Walton, Zandra E., Patel, Chirag H., Brooks, Rebekah C., Yu, Yongjun, Ibrahim-Hashim, Arig, Riddle, Malini, Porcu, Alessandra, Jiang, Tianying, Ecker, Brett L., Tameire, Feven, Koumenis, Constantinos, Weeraratna, Ashani T., Welsh, David K., Gillies, Robert, Alwine, James C., Zhang, Lin, Powell, Jonathan D., Dang, Chi V.

“…Recent reports indicate that hypoxia influences the circadian clock through the transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes…”
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MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells by Altman, Brian J., Hsieh, Annie L., Sengupta, Arjun, Krishnanaiah, Saikumari Y., Stine, Zachary E., Walton, Zandra E., Gouw, Arvin M., Venkataraman, Anand, Li, Bo, Goraksha-Hicks, Pankuri, Diskin, Sharon J., Bellovin, David I., Simon, M. Celeste, Rathmell, Jeffrey C., Lazar, Mitchell A., Maris, John M., Felsher, Dean W., Hogenesch, John B., Weljie, Aalim M., Dang, Chi V.

“…The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5′-CACGTG-3′), which are identical to the binding…”
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