Effects of oat β-glucan on innate immunity and infection after exercise stress

To test the effects of oat beta-glucan (ObetaG) on respiratory infection, macrophage antiviral resistance, and NK cytotoxicity. Mice were randomly assigned to one of four groups: Ex-H2O, Ex-ObetaG, Con-H2O, or Con-ObetaG. ObetaG was fed in the drinking water for 10 d before intranasal inoculation of...

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Published in:	Medicine and science in sports and exercise Vol. 36; no. 8; pp. 1321 - 1327
Main Authors:	DAMS, J. Mark, MURPHY, Elizabeth A, BROWN, Adrienne S, CARMICHAEL, Martin D, GHAFFAR, Abdul, MAYER, Eugene P
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-08-2004
Subjects:	Animals Avena - chemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Glucans - pharmacology Herpesvirus 1, Human - immunology Immunity, Innate - drug effects Killer Cells, Natural - immunology Macrophages, Peritoneal - immunology Male Mice Physical Conditioning, Animal Space life sciences Stress, Physiological - immunology Stress, Physiological - physiopathology Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports Physical exercise Human Oat Nutrition Mortality Immunity Morbidity Stress Natural killer cell Infection Sport HSV-1 Cereal Macrophage
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Summary:	To test the effects of oat beta-glucan (ObetaG) on respiratory infection, macrophage antiviral resistance, and NK cytotoxicity. Mice were randomly assigned to one of four groups: Ex-H2O, Ex-ObetaG, Con-H2O, or Con-ObetaG. ObetaG was fed in the drinking water for 10 d before intranasal inoculation of HSV-1 or sacrifice. Exercise consisted of treadmill running to volitional fatigue (approximately 140 min) for three consecutive days. Fifteen minutes after the last bout of exercise or rest, mice (N = 24) were intranasally inoculated with a standardized dose of HSV-1. Mice were monitored twice daily for morbidity and mortality. Additional mice were sacrificed after exercise, peritoneal macrophages were obtained via i.p. lavage and assayed for antiviral resistance to HSV-1 (N = 18), and spleens were harvested and assayed for NK cell cytotoxicity (N = 12). Exercise stress was associated with a 28% increase in morbidity (P = 0.036) and 18% increase in mortality (P = 0.15). Ingestion of ObetaG before infection prevented this increase in morbidity (P = 0.048) and mortality (P = 0.05). Exercise stress was associated with a decrease in macrophage antiviral resistance (P = 0.007), which was blocked by ingestion of ObetaG (P < 0.001). There were no effects of exercise or ObetaG on NK cytotoxicity. These data suggest that daily ingestion of ObetaG may offset the increased risk of URTI associated with exercise stress, which may be mediated, at least in part, by an increase in macrophage antiviral resistance.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0195-9131 1530-0315
DOI:	10.1249/01.MSS.0000135790.68893.6D