Search Results - "DAMORE, Michael"

The Architecture and Evolution of Cancer Neochromosomes by Garsed, Dale W., Marshall, Owen J., Corbin, Vincent D.A., Hsu, Arthur, Di Stefano, Leon, Schröder, Jan, Li, Jason, Feng, Zhi-Ping, Kim, Bo W., Kowarsky, Mark, Lansdell, Ben, Brookwell, Ross, Myklebost, Ola, Meza-Zepeda, Leonardo, Holloway, Andrew J., Pedeutour, Florence, Choo, K.H. Andy, Damore, Michael A., Deans, Andrew J., Papenfuss, Anthony T., Thomas, David M.

“…We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes,…”
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Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial by Bahlis, Nizar J., Costello, Caitlin L., Raje, Noopur S., Levy, Moshe Y., Dholaria, Bhagirathbhai, Solh, Melhem, Tomasson, Michael H., Damore, Michael A., Jiang, Sibo, Basu, Cynthia, Skoura, Athanasia, Chan, Edward M., Trudel, Suzanne, Jakubowiak, Andrzej, Gasparetto, Cristina, Chu, Michael P., Dalovisio, Andrew, Sebag, Michael, Lesokhin, Alexander M.

“…Multiple myeloma (MM) is a plasma cell malignancy expressing B cell maturation antigen (BCMA). Elranatamab, a bispecific antibody, engages BCMA on MM and CD3…”
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Safety, tolerability, and pharmacokinetics of anti-EGFRvIII antibody–drug conjugate AMG 595 in patients with recurrent malignant glioma expressing EGFRvIII by Rosenthal, Mark, Curry, Richard, Reardon, David A., Rasmussen, Erik, Upreti, Vijay V., Damore, Michael A., Henary, Haby A., Hill, John S., Cloughesy, Timothy

“…Purpose Epidermal growth factor receptor variant III (EGFRvIII) is expressed in a significant percentage of primary and recurrent glioblastoma (GBM), a common…”
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Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti–Interferon‐γ Antibody, in Patients With Discoid Lupus Erythematosus by Werth, Victoria P., Fiorentino, David, Sullivan, Barbara A., Boedigheimer, Michael J., Chiu, Kit, Wang, Christine, Arnold, Gregory E., Damore, Michael A., Bigler, Jeannette, Welcher, Andrew A., Russell, Chris B., Martin, David A., Chung, James B.

“…Objective Interferon‐γ (IFNγ) is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study sought to evaluate a single dose of AMG 811,…”
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Rilotumumab Resistance Acquired by Intracrine Hepatocyte Growth Factor Signaling by Cecchi, Fabiola, Rex, Karen, Schmidt, Joanna, Vocke, Cathy D, Lee, Young H, Burkett, Sandra, Baker, Daniel, Damore, Michael A, Coxon, Angela, Burgess, Teresa L, Bottaro, Donald P

“…Drug resistance is a long-standing impediment to effective systemic cancer therapy and acquired drug resistance is a growing problem for molecularly-targeted…”
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Blockade of Interferon‐γ Normalizes Interferon‐Regulated Gene Expression and Serum CXCL10 Levels in Patients With Systemic Lupus Erythematosus by Welcher, Andrew A., Boedigheimer, Michael, Kivitz, Alan J., Amoura, Zahir, Buyon, Jill, Rudinskaya, Alla, Latinis, Kevin, Chiu, Kit, Oliner, Kelly S., Damore, Michael A., Arnold, Gregory E., Sohn, Winnie, Chirmule, Narendra, Goyal, Lovely, Banfield, Christopher, Chung, James B.

“…Objective To assess the safety and immunologic impact of inhibiting interferon‐γ (IFNγ) with AMG 811, a human IgG1 monoclonal antibody against IFNγ, in…”
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In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models by Hughes, Paul E, Rex, Karen, Caenepeel, Sean, Yang, Yajing, Zhang, Yihong, Broome, Martin A, Kha, Hue T, Burgess, Teresa L, Amore, Benny, Kaplan-Lefko, Paula J, Moriguchi, Jodi, Werner, Jonathan, Damore, Michael A, Baker, Daniel, Choquette, Deborah M, Harmange, Jean-Christophe, Radinsky, Robert, Kendall, Richard, Dussault, Isabelle, Coxon, Angela

“…The MET receptor tyrosine kinase is involved in cell growth, survival, and invasion. Clinical studies with small molecule MET inhibitors have shown the role of…”
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Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases by Bae, Heekyong R., Leung, Patrick S.C., Hodge, Deborah L., Fenimore, John M., Jeon, Seon-Min, Thovarai, Vishal, Dzutsev, Amiran, Welcher, Andrew A., Boedigheimer, Michael, Damore, Michael A., Choi, Myung-Sook, Fravell, Richard A., Trinchieri, Giorgio, Gershwin, M. Eric, Young, Howard A.

“…Low grade, chronic inflammation is a critical risk factor for immunologic dysfunction including autoimmune diseases. However, the multiplicity of complex…”
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AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling by Sherman, Mara H., Kuraishy, Ali I., Deshpande, Chetan, Hong, Jason S., Cacalano, Nicholas A., Gatti, Richard A., Manis, John P., Damore, Michael A., Pellegrini, Matteo, Teitell, Michael A.

“…During an immune response, B cells undergo rapid proliferation and activation-induced cytidine deaminase (AID)-dependent remodeling of immunoglobulin (IG)…”
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Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-γ monoclonal antibody, in SLE subjects without or with lupus nephritis by Boedigheimer, Michael J, Martin, David A, Amoura, Zahir, Sánchez-Guerrero, Jorge, Romero-Diaz, Juanita, Kivitz, Alan, Aranow, Cynthia, Chan, Tak Mao, Chong, Yip Boon, Chiu, Kit, Wang, Christine, Sohn, Winnie, Arnold, Gregory E, Damore, Michael A, Welcher, Andrew A, Sullivan, Barbara A, Kotzin, Brian L, Chung, James B

“…ObjectiveTo evaluate safety, pharmacokinetics and pharmacodynamics of anti-interferon (IFN)-γ monoclonal antibody AMG 811 in subjects with SLE without or with…”
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BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time by Luo, Yi, Bolon, Brad, Damore, Michael A, Fitzpatrick, Dan, Liu, Hantao, Zhang, Jianhua, Yan, Qiao, Vassar, Robert, Citron, Martin

“…The formation of Alzheimer's Aβ peptide is initiated when the amyloid precursor protein (APP) is cleaved by the enzyme β-secretase (BACE1); inhibition of this…”
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Sclerostin expression is induced by BMPs in human Saos-2 osteosarcoma cells but not via direct effects on the sclerostin gene promoter or ECR5 element by Yu, Longchuan, der Valk, Marissa van, Cao, Jin, Han, Chun-Ya E, Juan, Todd, Bass, Michael B, Deshpande, Chetan, Damore, Michael A, Stanton, Richard, Babij, Philip

“…Abstract Sclerostin is a secreted inhibitor of Wnt signaling and plays an essential role in the regulation of bone mass. The expression of sclerostin is…”
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Gene Expression Profiles Can Predict Panitumumab Monotherapy Responsiveness in Human Tumor Xenograft Models by Boedigheimer, Michael J, Freeman, Daniel J, Kiaei, Panteha, Damore, Michael A, Radinsky, Robert

“…Abstract Background Epidermal growth factor receptor (EGFR)-targeted agents have demonstrated clinical benefit in patients with cancer. Identifying…”
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HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells by Wilson, Cindy A, Cajulis, Elaina E, Green, Jennifer L, Olsen, Taylor M, Chung, Young Ah, Damore, Michael A, Dering, Judy, Calzone, Frank J, Slamon, Dennis J

“…Amplification of the HER-2 receptor tyrosine kinase has been implicated in the pathogenesis and aggressive behavior of approximately 25% of invasive human…”
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Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice by Juan, Todd, Véniant, Murielle M., Helmering, Joan, Babij, Philip, Baker, Daniel M., Damore, Michael A., Bass, Michael B., Gyuris, Tibor, Chhoa, Mark, Li, Chi-Ming, Ebeling, Chris, Amato, Julie, Carlson, George A., Lloyd, David J.

“…We conducted a genome-wide screen using the mutagen N-ethyl-N-nitrosourea to identify recessive mutations in genes that lead to altered lipid traits in mice…”
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TCL1 Oncogene Expression in AIDS-Related Lymphomas and Lymphoid Tissues by Teitell, Michael, Damore, Michael A., Sulur, Girija G., Turner, Devin E., Stern, Marc-Henri, Said, Jonathan W., Denny, Christopher T., Wall, Randolph

“…AIDS-related non-Hodgkin's lymphoma (AIDS NHL) comprises a diverse and heterogeneous group of high-grade B cell tumors. Certain classes of AIDS NHL are…”
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Use of a mixed tissue RNA design for performance assessments on multiple microarray formats by Thompson, Karol L., Rosenzweig, Barry A., Pine, P. Scott, Retief, Jacques, Turpaz, Yaron, Afshari, Cynthia A., Hamadeh, Hisham K., Damore, Michael A., Boedigheimer, Michael, Blomme, Eric, Ciurlionis, Rita, Waring, Jeffrey F., Fuscoe, James C., Paules, Richard, Tucker, Charles J., Fare, Thomas, Coffey, Ernest M., He, Yudong, Collins, Patrick J., Jarnagin, Kurt, Fujimoto, Susan, Ganter, Brigitte, Kiser, Gretchen, Kaysser-Kranich, Tamma, Sina, Joseph, Sistare, Frank D.

“…The comparability and reliability of data generated using microarray technology would be enhanced by use of a common set of standards that allow accuracy,…”
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Genes expressed during the IFNγ-induced maturation of pre-B cells by Patrone, Lisa, Damore, Michael A, Lee, Michael B, Malone, Cindy Sue, Wall, Randolph

“…Interferon-gamma (IFNγ) exerts diverse responses in B cell development ranging from growth arrest and apoptosis to proliferation and differentiation. IFNγ…”
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Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt by Anderson, Abraham A, Helmering, Joan, Juan, Todd, Li, Chi-Ming, McCormick, Jocelyn, Graham, Melissa, Baker, Daniel M, Damore, Michael A, Véniant, Murielle M, Lloyd, David J

“…C57BLKS/J (BLKS) mice are susceptible to islet exhaustion in insulin-resistant states as compared with C57BL6/J (B6) mice, as observed by the presence of the…”
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Molecular features and outcomes for patients receiving elranatamab for relapsed or refractory multiple myeloma in MagnetisMM-1 by Tomasson, Michael H., Bahlis, Nizar J., Costello, Caitlin, Raje, Noopur S., Levy, Moshe Y., Dholaria, Bhagirathbhai R., Solh, Melhem M., Damore, Michael A., Jiang, Sibo, Xie, Tao, Basu, Cynthia, Skoura, Athanasia, Chan, Edward Michael, Trudel, Suzanne, Jakubowiak, Andrzej J., Gasparetto, Cristina, Chu, Michael, Dalovisio, Andrew Peter, Sebag, Michael, Lesokhin, Alexander M.

“…e20021 Background: Multiple myeloma (MM) is a plasma cell dyscrasia that expresses B-cell maturation antigen (BCMA). Elranatamab (PF-06863135), a BCMA x CD3…”
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