Search Results - "DAMMANN, Reinhard"

The RASSF proteins in cancer; from epigenetic silencing to functional characterization by Richter, Antje M., Pfeifer, Gerd P., Dammann, Reinhard H.

“…The Ras-Association Domain Family (RASSF) comprises ten members, termed RASSF1 to RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and…”
Get full text

Impact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in Cancer by Dammann, Reinhard H, Richter, Antje M, Jiménez, Adriana P, Woods, Michelle, Küster, Miriam, Witharana, Chamindri

“…Epigenetic inactivation of tumor suppressor genes (TSG) is a fundamental event in the pathogenesis of human cancer. This silencing is accomplished by aberrant…”
Get full text

Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline Personality Disorder by Teschler, Stefanie, Gotthardt, Julia, Dammann, Gerhard, Dammann, Reinhard H

“…Borderline personality disorder (BPD) is a serious psychic disease with a high risk for suicide. DNA methylation is a hallmark for aberrant epigenetic…”
Get full text

Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma by STEINMANN, Katrin, SANDNER, Annett, SCHAGDARSURENGIN, Undraga, DAMMANN, Reinhard H

“…Squamous cell carcinomas of head and neck (HNSCC) are a result of multiple genetic and epigenetic alterations. Epigenetic inactivation of tumor suppressor…”
Get full text

SIAH3 is frequently epigenetically silenced in cancer and regulates mitochondrial metabolism by Deutschmeyer, Verena E, Schlaudraff, Nico A, Walesch, Sara K, Moyer, Janine, Sokol, Anna M, Graumann, Johannes, Meissner, Wolfgang, Schneider, Marc, Muley, Thomas, Helmbold, Peter, Schwinn, Markus, Richter, Antje M, Schmitz, M Lienhard, Dammann, Reinhard H

“…Of the seven in absentia homologue (SIAH) family, three members have been identified in the human genome. In contrast to the E3 ubiquitin ligase encoding SIAH1…”
Get full text

RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice by Richter, Antje M., Woods, Michelle L., Küster, Miriam M., Walesch, Sara K., Braun, Thomas, Boettger, Thomas, Dammann, Reinhard H.

“…Kidney cancer incidences are rising globally, thereby fueling the demand for targeted therapies and precision medicine. In our previous work, we have…”
Get full text

Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner by Woods, Michelle L., Weiss, Astrid, Sokol, Anna M., Graumann, Johannes, Boettger, Thomas, Richter, Antje M., Schermuly, Ralph T., Dammann, Reinhard H.

“…Silencing of the Apoptosis associated Tyrosine Kinase gene ( AATK ) has been described in cancer. In our study, we specifically investigated the epigenetic…”
Get full text

The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth by Jiménez, Adriana P, Traum, Annalena, Boettger, Thomas, Hackstein, Holger, Richter, Antje M, Dammann, Reinhard H

“…The Hippo pathway regulates organ size, growth and comprises several tumor related factors, including the oncoprotein YAP1 and the tumor suppressor RASSF1A. is…”
Get full text

Increased DNA methylation of neuropsychiatric genes occurs in borderline personality disorder by Dammann, Gerhard, Teschler, Stefanie, Haag, Tanja, Altmüller, Franziska, Tuczek, Frederik, Dammann, Reinhard H.

“…Borderline personality disorder (BPD) is a complex psychiatric disease of increasing importance. Epigenetic alterations are hallmarks for altered gene…”
Get full text

The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype by Traum, Annalena, Jehle, Stefanie, Waxmann, Yannick, Litmeyer, Anne-Sophie, Berghöfer, Heike, Bein, Gregor, Dammann, Reinhard, Perniss, Alexander, Burg-Roderfeld, Monika, Sachs, Ulrich J, Bayat, Behnaz

“…CD177 is a glycosyl phosphatidyl inositol (GPI)-linked, neutrophil-specific glycoprotein that in 3-5% of normal individuals is absent from all neutrophils. The…”
Get full text

Methylation of PTEN as a Prognostic Factor in Malignant Melanoma of the Skin by Lahtz, Christoph, Stranzenbach, René, Fiedler, Eckhard, Helmbold, Peter, Dammann, Reinhard H.

Get full text

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer by Kiehl, Steffen, Zimmermann, Tobias, Savai, Rajkumar, Pullamsetti, Soni S., Seeger, Werner, Bartkuhn, Marek, Dammann, Reinhard H.

“…Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation…”
Get full text

Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences by Schagdarsurengin, Undraga, Richter, Antje M, Hornung, Juliane, Lange, Cornelia, Steinmann, Katrin, Dammann, Reinhard H

“…The Ras association domain family (RASSF) encodes for distinct tumor suppressors and several members are frequently silenced in human cancer. In our study, we…”
Get full text

Validation of Tuba1a as appropriate internal control for normalization of gene expression analysis during mouse lung development by Mehta, Aditi, Dobersch, Stephanie, Dammann, Reinhard H, Bellusci, Saverio, Ilinskaya, Olga N, Braun, Thomas, Barreto, Guillermo

“…The expression ratio between the analysed gene and an internal control gene is the most widely used normalization method for quantitative RT-PCR (qRT-PCR)…”
Get full text

Claudin11 Promoter Hypermethylation Is Frequent in Malignant Melanoma of the Skin, but Uncommon in Nevus Cell Nevi by Walesch, Sara K, Richter, Antje M, Helmbold, Peter, Dammann, Reinhard H

“…Epigenetic inactivation of tumor-related genes is an important characteristic in the pathology of human cancers, including melanomagenesis. We analyzed the…”
Get full text

Aberrant Promoter Methylation of the Tumour Suppressor RASSF10 and Its Growth Inhibitory Function in Breast Cancer by Richter, Antje M, Walesch, Sara K, Dammann, Reinhard H

“…Breast cancer is the most common cancer in women, with 1.7 million new cases each year. As early diagnosis and prognosis are crucial factors in cancer…”
Get full text

RASSF10 Promoter Hypermethylation Is Frequent in Malignant Melanoma of the Skin but Uncommon in Nevus Cell Nevi by Helmbold, Peter, Richter, Antje M., Walesch, Sara, Skorokhod, Alexander, Marsch, Wolfgang Ch, Enk, Alexander, Dammann, Reinhard H.

“…The Ras association domain family (RASSF) consists of several tumor suppressor genes, which are frequently silenced in human cancers. We analyzed the…”
Get full text

Frequent hypermethylation of RASSF1A tumour suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancer by Helmbold, Peter, Lahtz, Christoph, Herpel, Esther, Schnabel, Philipp A, Dammann, Reinhard H

“…Abstract In small cell lung cancer (SCLC), hypermethylation of the tumour suppressor Ras association domain family 1A ( RASSF1A ) is frequent. It is associated…”
Get full text

RASSF1A Is Part of a Complex Similar to the Drosophila Hippo/Salvador/Lats Tumor-Suppressor Network by Guo, Cai, Tommasi, Stella, Liu, Limin, Yee, Jiing-Kuan, Dammann, Reinhard, Pfeifer, Gerd P.

“…The Ras Association Domain Family 1A ( RASSF1A) gene is one of the most frequently silenced genes in human cancer. RASSF1A has been shown to interact with the…”
Get full text

Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1 by Zhang, Xiaoying, Guo, Cai, Wu, Xiwei, Li, Arthur X, Liu, Limin, Tsark, Walter, Dammann, Reinhard, Shen, Hui, Vonderfecht, Steven L, Pfeifer, Gerd P

“…The tumor suppressor gene RASSF1A is epigenetically silenced in most human cancers. As a binding partner of the kinases MST1 and MST2, the mammalian orthologs…”
Get full text