Search Results - "DALKARA, Turgay"

Can Restoring Incomplete Microcirculatory Reperfusion Improve Stroke Outcome after Thrombolysis? by Dalkara, Turgay, Arsava, Ethem Murat

“…Substantial experimental data and recent clinical evidence suggesting that tissue reperfusion is a better predictor of outcome after thrombolysis than…”
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What is a pericyte? by Attwell, David, Mishra, Anusha, Hall, Catherine N, O’Farrell, Fergus M, Dalkara, Turgay

“…Pericytes, spatially isolated contractile cells on capillaries, have been reported to control cerebral blood flow physiologically, and to limit blood flow…”
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Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection by Alarcon-Martinez, Luis, Yilmaz-Ozcan, Sinem, Yemisci, Muge, Schallek, Jesse, Kılıç, Kıvılcım, Can, Alp, Di Polo, Adriana, Dalkara, Turgay

“…Recent evidence suggests that capillary pericytes are contractile and play a crucial role in the regulation of microcirculation. However, failure to detect…”
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Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine by Erdener, Şefik Evren, Kaya, Zeynep, Dalkara, Turgay

“…Background Pain is generally concomitant with an inflammatory reaction at the site where the nociceptive fibers are activated. Rodent studies suggest that a…”
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Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery by Dalkara, Turgay, Yemisci, Muge, Gursoy-Ozdemir, Yasemin, Vural, Atay, Can, Alp, Topalkara, Kamil

“…Ischemia causes pericytes on brain microvessels to contract, obstructing erythrocyte transit even after blood flow is restored. This contraction, which depends…”
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Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline by Østergaard, Leif, Engedal, Thorbjørn S, Moreton, Fiona, Hansen, Mikkel B, Wardlaw, Joanna M, Dalkara, Turgay, Markus, Hugh S, Muir, Keith W

“…Cerebral small vessel disease (SVD) gives rise to one in five strokes worldwide and constitutes a major source of cognitive decline in the elderly. SVD is…”
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Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels by Karatas, Hulya, Erdener, Sefik Evren, Gursoy-Ozdemir, Yasemin, Lule, Sevda, Eren-Koçak, Emine, Sen, Zümrüt Duygu, Dalkara, Turgay

“…The initial phase in the development of a migraine is still poorly understood. Here, we describe a previously unknown signaling pathway between stressed…”
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Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression by Eren-Koçak, Emine, Dalkara, Turgay

“…Migraine and major depression are debilitating disorders with high lifetime prevalence rates. Interestingly these disorders are highly comorbid and show…”
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Migraine aura pathophysiology: the role of blood vessels and microembolisation by Dalkara, Turgay, MD, Nozari, Ala, MD, Moskowitz, Michael A, MD

“…Summary Migraine attacks with auras are sometimes associated with underlying hereditary or acquired cerebrovascular disorders. A unifying pathophysiological…”
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Microvascular protection is essential for successful neuroprotection in stroke by Gursoy-Ozdemir, Yasemin, Yemisci, Muge, Dalkara, Turgay

“…Currently, the best way of neuroprotection for acute ischemic stroke appears to be restoration of blood flow to the ischemic area by thrombolysis…”
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F-actin polymerization contributes to pericyte contractility in retinal capillaries by Kureli, Gulce, Yilmaz-Ozcan, Sinem, Erdener, Sefik Evren, Donmez-Demir, Buket, Yemisci, Muge, Karatas, Hulya, Dalkara, Turgay

“…Although it has been documented that central nervous system pericytes are able to contract in response to physiological, pharmacological or pathological…”
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Unraveling the interplay of neuroinflammatory signaling between parenchymal and meningeal cells in migraine headache by Dalkara, Turgay, Kaya, Zeynep, Erdener, Şefik Evren

“…Background The initiation of migraine headaches and the involvement of neuroinflammatory signaling between parenchymal and meningeal cells remain unclear…”
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The Brain, the Eating Plate, and the Gut Microbiome: Partners in Migraine Pathogenesis by Gazerani, Parisa, Papetti, Laura, Dalkara, Turgay, Cook, Calli Leighann, Webster, Caitlin, Bai, Jinbing

“…This review summarizes the relationship between diet, the gut microbiome, and migraine. Key findings reveal that certain dietary factors, such as caffeine and…”
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Systemically Administered Brain-Targeted Nanoparticles Transport Peptides across the Blood—Brain Barrier and Provide Neuroprotection by Yemisci, Muge, Caban, Secil, Gursoy-Ozdemir, Yasemin, Lule, Sevda, Novoa-Carballal, Ramon, Riguera, Ricardo, Fernandez-Megia, Eduardo, Andrieux, Karine, Couvreur, Partick, Capan, Yilmaz, Dalkara, Turgay

“…Although growth factors and anti-apoptotic peptides have been shown to be neuroprotective in stroke models, translation of these experimental findings to…”
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Inadequate brain glycogen or sleep increases spreading depression susceptibility by Kilic, Kivilcim, Karatas, Hulya, Dönmez‐Demir, Buket, Eren‐Kocak, Emine, Gursoy‐Ozdemir, Yasemin, Can, Alp, Petit, Jean‐Marie, Magistretti, Pierre J., Dalkara, Turgay

“…Objective Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep…”
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Widespread brain parenchymal HMGB1 and NF-κB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice by Dehghani, Anisa, Phisonkunkasem, Thas, Yilmaz Ozcan, Sinem, Dalkara, Turgay, van den Maagdenberg, Arn M.J.M., Tolner, Else A., Karatas, Hulya

“…Neuroinflammatory changes involving neuronal HMGB1 release and astrocytic NF-κB nuclear translocation occur following cortical spreading depolarization (CSD)…”
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Suppression of cortical spreading depression in migraine prophylaxis by Ayata, Cenk, Jin, Hongwei, Kudo, Chiho, Dalkara, Turgay, Moskowitz, Michael A.

“…Objective Topiramate, valproate, propranolol, amitriptyline, and methysergide have been widely prescribed for migraine prophylaxis, but their mechanism or site…”
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The effect of P2X7 antagonism on subcortical spread of optogenetically-triggered cortical spreading depression and neuroinflammation by Uzay, Burak, Donmez-Demir, Buket, Ozcan, Sinem Yilmaz, Kocak, Emine Eren, Yemisci, Muge, Ozdemir, Yasemin Gursoy, Dalkara, Turgay, Karatas, Hulya

“…Migraine is a neurological disorder characterized by episodes of severe headache. Cortical spreading depression (CSD), the electrophysiological equivalent of…”
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A Nanomedicine Transports a Peptide Caspase-3 Inhibitor across the Blood-Brain Barrier and Provides Neuroprotection by Karatas, Hulya, Aktas, Yesim, Gursoy-Ozdemir, Yasemin, Bodur, Ebru, Yemisci, Muge, Caban, Secil, Vural, Atay, Pinarbasli, Onur, Capan, Yilmaz, Fernandez-Megia, Eduardo, Novoa-Carballal, Ramon, Riguera, Ricardo, Andrieux, Karine, Couvreur, Patrick, Dalkara, Turgay

“…Caspases play an important role as mediators of cell death in acute and chronic neurological disorders. Although peptide inhibitors of caspases provide…”
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Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes by Kaya, Zeynep, Belder, Nevin, Sever-Bahcekapili, Melike, Donmez-Demir, Buket, Erdener, Şefik Evren, Bozbeyoglu, Naz, Bagci, Canan, Eren-Kocak, Emine, Yemisci, Muge, Karatas, Hulya, Erdemli, Esra, Gursel, Ihsan, Dalkara, Turgay

“…The role of high mobility group box 1 (HMGB1) in inflammation is well characterized in the immune system and in response to tissue injury. More recently, HMGB1…”
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