Search Results - "DALI, Mandar"

Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent by Jernigan, Finith, Branstrom, Arthur, Baird, John D, Cao, Liangxian, Dali, Mandar, Furia, Bansri, Kim, Min Jung, O'Keefe, Kylie, Kong, Ronald, Laskin, Oscar L, Colacino, Joseph M, Pykett, Mark, Mollin, Anna, Sheedy, Josephine, Dumble, Melissa, Moon, Young-Choon, Sheridan, Richard, Mühlethaler, Tobias, Spiegel, Robert J, Prota, Andrea E, Steinmetz, Michel O, Weetall, Marla

“…PTC596 is an investigational small-molecule tubulin-binding agent. Unlike other tubulin-binding agents, PTC596 is orally bioavailable and is not a…”
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Effect of pepsin on maintaining the supersaturation of the HCl salt of a weakly basic drug: a case study by Pinnamaneni, Swathi, Rinaldi, Frank A., Jayawickrama, Dimuthu A., Li, Jinjiang, Dali, Mandar V.

“…The impact of pepsin on the maintenance of supersaturated solution of the HCl salt of a weakly basic drug was evaluated in simulated gastric fluid by…”
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The effect of the physical states of binders on high-shear wet granulation and granule properties: a mechanistic approach towards understanding high-shear wet granulation process. Part I. Physical characterization of binders by Li, Jinjiang, Tao, Li, Dali, Mandar, Buckley, David, Gao, Julia, Hubert, Mario

“…In this study, the objective is to investigate the effect of the physical state of a binder on wet granulation and granule properties using a binary model…”
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Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation by Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young-Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spiegel, Robert, Peltz, Stuart W.

“…PTC299 is a novel small molecule that specifically blocks the production of protein from selected mRNAs that under certain conditions use noncanonical…”
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Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: Synthesis and biological properties by UEDA, Yasutsugu, MATISKELLA, John D, VARIA, Sailesh, KNIPE, Jay, MING ZHENG, MATHEW, Marina, MOSURE, Kathy, CLARK, Junius, LAMB, Lucinda, MEDIN, Ivette, QI GAO, HUANG, Stella, GOLIK, Jerzy, CHEN, Chung-Pin, BRONSON, Joanne J, CONNOLLY, Timothy P, HUDYMA, Thomas W, VENKATESH, Srini, DALI, Mandar, KANG, Shin-Hong, BARBOUR, Nancy, TEJWANI, Ravi

“…Synthesis of phosphonooxymethyl derivatives of ravuconazole, 2 (BMS-379224) and 3 (BMS-315801) and their biological evaluation as potential water-soluble…”
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First‐in‐Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15‐Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis by Gao, Lan, Giannousis, Peter, Thoolen, Martin, Kaushik, Diksha, Latham, Joey, Tansy, Aaron, Ma, Jiyuan, Johnston, Mayzie, Dali, Mandar, Golden, Lee, Klein, Matthew, Kong, Ronald, Trimmer, Jeffrey

“…Utreloxastat (PTC857) is a 15‐lipoxygenase inhibitor being developed to treat amyotrophic lateral sclerosis. This first‐in‐human study investigated the safety…”
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Particle Size Distributions in Mesh Cuts and Microscopically Estimated Volumetric Shape Factors by Carstensen, J. T., Dali, Mandar

“…When particle size distribution parameters are calculated from sieve analysis, it is generally assumed that the distribution within the particle cut is either…”
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The effect of the physical states of binders on high-shear wet granulation and granule properties: a mechanistic approach toward understanding high-shear wet granulation process. Part II. Granulation and granule properties by Li, Jinjiang, Tao, Li, Dali, Mandar, Buckley, David, Gao, Julia, Hubert, Mario

“…The objective is to provide mechanistic understanding of a preferred wet granulation process that a binder is added in a dry state. Blends of CaCO(3) and…”
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Understanding drug-excipient compatibility: Oxidation of compound A in a solid dosage form by Wu, Yongmei, Dali, Mandar, Gupta, Abhishek, Raghavan, Krishnaswamy

“…Drug-excipient compatibility studies lay the foundation for designing a chemically stable formulation for clinical and commercial development. This article…”
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Determination of Mass Transfer Dissolution Rate Constants from Critical Time of Dissolution of a Powder Sample by Carstensen, J., Dali, Mandar

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Effect of change in shape factor of a single crystal on its dissolution behavior by DALI, M. V, CARSTENSEN, J. T

“…To study the effect of change in the shape factor of real crystals on their dissolution behavior using a potassium dichromate crystal as a model for…”
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Determination of Mass Transfer Dissolution Rate Constants from Critical Time of Dissolution of a Powder Sample by Dali, Mandar

“…ABSTRACT This article presents a method for obtaining mass transfer dissolution rate constants of polydisperse, particulate solids under given hydrodynamic…”
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Particle Size Distributions from Multiparticulate Dissolution by Dali, Mandar V., Carstensen, J. T.

“…Abstract It has been demonstrated theoretically that the particle size distribution of particles in a given sieve fraction of a powder may be assessed by means…”
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Powder dissolution as a tool to estimate particle size and shape parameters of crystalline solids by Dali, Mandar Vasant

“…A parallelepiped geometry has been considered to mimic real particles, instead of a spherical approximation. A model that describes the dissolution of a single…”
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Calculation of Intensified Sampling Plans in Blending Validation by Carstensen, J. T., Dali, Mandar, Pudipeddi, Madhu

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Blending validation of low drug content dosage forms by Carstensen, J T, Dali, M, Pudipeddi, M

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