Search Results - "DAL CANTO, M. C"

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis by Dal Canto, MC, Gurney, ME

“…Transgenic mice expressing mutant Cu,Zn superoxide dismutase (SOD), containing a substitution of glycine at position 93 by alanine, develop disease prevalently…”
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A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis by DAL CANTO, M. C, GURNEY, M. E

“…About 15-20% of patients with familial amyotrophic lateral sclerosis (ALS) carry one of several missense mutations in the gene for Cu,Zn superoxide dismutase…”
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Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis by McRae, B L, Vanderlugt, C L, Dal Canto, M C, Miller, S D

“…The role of epitope spreading in the pathology of relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE) was examined. Using peripherally…”
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Motor Neuron Degeneration in Mice That Express a Human Cu,Zn Superoxide Dismutase Mutation by Gurney, Mark E., Pu, Haifeng, Chiu, Arlene Y., Mauro C. Dal Canto, Polchow, Cynthia Y., Alexander, Denise D., Caliendo, Jan, Hentati, Afif, Kwon, Young W., Deng, Han-Xiang, Chen, Wenje, Zhai, Ping, Sufit, Robert L., Siddique, Teepu

“…Mutations of human Cu,Zn superoxide dismutase (SOD) are found in about 20 percent of patients with familial amyotrophic lateral sclerosis (ALS). Expression of…”
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Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS) by Dal Canto, Mauro C., Gurney, Mark E.

“…Two different lines of mice, G1 and G20, carrying a transgene for a mutant form of Cu,Zn SOD, found in a family with familial amyotrophic lateral sclerosis…”
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The Golgi Apparatus of Spinal Cord Motor Neurons in Transgenic Mice Expressing Mutant Cu,Zn Superoxide Dismutase Becomes Fragmented in Early, Preclinical Stages of the Disease by Mourelatos, Zissimos, Gonatas, Nicholas K., Stieber, Anna, Gurney, Mark E., Mauro C. Dal Canto

“…Dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral…”
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Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519 by VANDERLUGT, C. L, RAHBE, S. M, ELLIOTT, P. J, DAL CANTO, M. C, MILLER, S. D

“…PLP139-151-induced relapsing experimental autoimmune encephalomyelitis (R-EAE) in SJL mice is a Th1-mediated autoimmune demyelinating disease model for…”
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Specific immune regulation of chronic-relapsing experimental allergic encephalomyelitis in mice by Kennedy, MK, Dal Canto, MC, Trotter, JL, Miller, SD

“…These studies were designed to examine immunologic means of regulating the clinical course of murine chronic-relapsing experimental allergic encephalomyelitis…”
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Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease by MELVOLD, R. W, JOKINEN, D. M, MILLER, S. D, DAL CANTO, M. C, LIPTON, H. L

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The 5' noncoding sequences from a less virulent Theiler's virus dramatically attenuate GDVII neurovirulence by LIPTON, H. L, CALENOFF, M, BANDYOPADHYAY, P, MILLER, S. D, DAL CANTO, M. C, GERETY, S, JENSEN, K

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Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy by Koenig, Scott, Gendelman, Howard E., Orenstein, Jan M., Canto, Mauro C., Pezeshkpour, Gholam H., Yungbluth, Margaret, Janotta, Frank, Aksamit, Allen, Martin, Malcolm A., Fauci, Anthony S.

“…One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive…”
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The Golgi apparatus and the pathogenesis of Alzheimer's disease by DAL CANTO, M. C

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Class I-deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination by Pullen, L C, Miller, S D, Dal Canto, M C, Kim, B S

“…Intracerebral inoculation of Theiler's murine encephalomyelitis virus (TMEV) results in immune-mediated demyelination in susceptible mouse strains. The…”
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Distal axonopathy in an alsin-deficient mouse model by Deng, Han-Xiang, Zhai, Hong, Fu, Ronggen, Shi, Yong, Gorrie, George H., Yang, Yi, Liu, Erdong, Dal Canto, Mauro C., Mugnaini, Enrico, Siddique, Teepu

“…Mutations in Alsin are associated with chronic juvenile amyotrophic lateral sclerosis (ALS2), juvenile primary lateral sclerosis and infantile-onset ascending…”
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Presence of Cu/Zn superoxide dismutase (SOD) immunoreactivity in neuronal hyaline inclusions in spinal cords from mice carrying a transgene for Gly93Ala mutant human Cu/Zn SOD by SHIBATA, N, HIRANO, A, KOBAYASHI, M, DAL CANTO, M. C, GURNEY, M. E, KOMORI, T, UMAHARA, T, ASAYAMA, K

“…This investigation deals with the immunocytochemical localization of Cu/Zn superoxide dismutase (SOD) in the spinal cord neurons of transgenic mice that…”
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CD28 Costimulatory Blockade Exacerbates Disease Severity and Accelerates Epitope Spreading in a Virus-Induced Autoimmune Disease by Neville, K L, Dal Canto, M C, Bluestone, J A, Miller, S D

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A virus-induced molecular mimicry model of multiple sclerosis by Olson, J K, Croxford, J L, Calenoff, M A, Dal Canto, M C, Miller, S D

“…Molecular mimicry is the process by which virus infection activates T cells that are cross-reactive with self antigens. Infection of SJL/J mice with the…”
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Effect of Theiler's murine encephalomyelitis virus and cytokines on cultured oligodendrocytes and astrocytes by Qi, Y., Dal Canto, M.C.

“…The pathogenesis of Theiler's murine encephalomyelitis virus (TMEV)‐induced demyelinating disease is still controversial. Our hypothesis is that primary…”
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Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV) by Clatch, R J, Miller, S D, Metzner, R, Dal Canto, M C, Lipton, H L

“…Knowledge of the cells in which Theiler's murine encephalomyelitis virus (TMEV) persists is crucial to understanding the pathogenesis of TMEV-induced…”
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Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides by Kennedy, MK, Tan, LJ, Dal Canto, MC, Tuohy, VK, Lu, ZJ, Trotter, JL, Miller, SD

“…Tolerization of SJL/J mice with splenocytes coupled with proteolipid protein (PLP), the major protein component of central nervous system myelin, resulted in…”
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