Search Results - "DAIRKEE, Shanaz H"

Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines by Powell, Ashley A, Talasaz, Amirali H, Zhang, Haiyu, Coram, Marc A, Reddy, Anupama, Deng, Glenn, Telli, Melinda L, Advani, Ranjana H, Carlson, Robert W, Mollick, Joseph A, Sheth, Shruti, Kurian, Allison W, Ford, James M, Stockdale, Frank E, Quake, Stephen R, Pease, R Fabian, Mindrinos, Michael N, Bhanot, Gyan, Dairkee, Shanaz H, Davis, Ronald W, Jeffrey, Stefanie S

“…To improve cancer therapy, it is critical to target metastasizing cells. Circulating tumor cells (CTCs) are rare cells found in the blood of patients with…”
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Aberrant regulation of the BST2 (Tetherin) promoter enhances cell proliferation and apoptosis evasion in high grade breast cancer cells by Sayeed, Aejaz, Luciani-Torres, Gloria, Meng, Zhenhang, Bennington, James L, Moore, Dan H, Dairkee, Shanaz H

“…Normal cellular phenotypes that serve an oncogenic function during tumorigenesis are potential candidates for cancer targeting drugs. Within a subset of…”
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Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women by Goodson, William H., Luciani, Maria Gloria, Sayeed, S. Aejaz, Jaffee, Ian M., Moore, Dan H., Dairkee, Shanaz H.

“…Breast cancer is an estrogen-driven disease. Consequently, hormone replacement therapy correlates with disease incidence. However, increasing male breast…”
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Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer by Zhou, Yamei, Yau, Christina, Gray, Joe W, Chew, Karen, Dairkee, Shanaz H, Moore, Dan H, Eppenberger, Urs, Eppenberger-Castori, Serenella, Benz, Christopher C

“…Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive…”
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Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene by Albertson, Donna G, Ylstra, Bauke, Segraves, Richard, Collins, Colin, Dairkee, Shanaz H, Kowbel, David, Kuo, Wen-Lin, Gray, Joe W, Pinkel, Daniel

“…We show here that quantitative measurement of DNA copy number across amplified regions using array comparative genomic hybridization (CGH) may facilitate…”
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High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays by Pinkel, Daniel, Segraves, Richard, Sudar, Damir, Clark, Steven, Poole, Ian, Kowbel, David, Collins, Colin, Kuo, Wen-Lin, Chen, Chira, Zhai, Ye, Dairkee, Shanaz H, Ljung, Britt-marie, Gray, Joe W, Albertson, Donna G

“…Gene dosage variations occur in many diseases. In cancer, deletions and copy number increases contribute to alterations in the expression of tumour-suppressor…”
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Distinctive responsiveness to stromal signaling accompanies histologic grade programming of cancer cells by Luciani, Maria Gloria, Seok, Junhee, Sayeed, Aejaz, Champion, Stacey, Goodson, William H, Jeffrey, Stefanie S, Xiao, Wenzhong, Mindrinos, Michael, Davis, Ronald W, Dairkee, Shanaz H

“…Whether stromal components facilitate growth, invasion, and dissemination of cancer cells or suppress neoplastic lesions from further malignant progression is…”
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Reduction of daily-use parabens and phthalates reverses accumulation of cancer-associated phenotypes within disease-free breast tissue of study subjects by Dairkee, Shanaz H., Moore, Dan H., Luciani, M. Gloria, Anderle, Nicole, Gerona, Roy, Ky, Karina, Torres, Samantha M., Marshall, Polly V., Goodson III, William H.

“…Estrogenic overstimulation is carcinogenic to the human breast. Personal care products (PCPs) commonly contain xenoestrogens (XE), such as parabens and…”
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A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue by Dairkee, Shanaz H, Ji, Youngran, Ben, Yong, Moore, Dan H, Meng, Zhenhang, Jeffrey, Stefanie S

“…To identify the spectrum of malignant attributes maintained outside the host environment, we have compared global gene expression in primary breast tumors and…”
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A Ternary Mixture of Common Chemicals Perturbs Benign Human Breast Epithelial Cells More Than the Same Chemicals Do Individually by Dairkee, Shanaz H, Luciani-Torres, Gloria, Moore, Dan H, Jaffee, Ian M, Goodson, 3rd, William H

“…As a continuous source of hormonal stimulation, environmentally ubiquitous estrogenic chemicals, ie, xenoestrogens (XEs), are a potential risk factor for…”
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Screening for Chemical Contributions to Breast Cancer Risk: A Case Study for Chemical Safety Evaluation by Schwarzman, Megan R, Ackerman, Janet M, Dairkee, Shanaz H, Fenton, Suzanne E, Johnson, Dale, Navarro, Kathleen M, Osborne, Gwendolyn, Rudel, Ruthann A, Solomon, Gina M, Zeise, Lauren, Janssen, Sarah

“…Current approaches to chemical screening, prioritization, and assessment are being reenvisioned, driven by innovations in chemical safety testing, new chemical…”
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Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells by Dairkee, Shanaz H, Luciani-Torres, M Gloria, Moore, Dan H, Goodson, 3rd, William H

“…Widespread distribution of bisphenol-A (BPA) complicates epidemiological studies of possible carcinogenic effects on the breast because there are few unexposed…”
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Exposure to the polyester PET precursor--terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells by Luciani-Torres, Maria Gloria, Moore, Dan H, Goodson, 3rd, William H, Dairkee, Shanaz H

“…Identification of early perturbations induced in cells from non-cancerous breast tissue is critical for understanding possible breast cancer risk from chemical…”
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Bisphenol A Induces a Profile of Tumor Aggressiveness in High-Risk Cells from Breast Cancer Patients by DAIRKEE, Shanaz H, SEOK, Junhee, CHAMPION, Stacey, SAYEED, Aejaz, MINDRINOS, Michael, WENZHONG XIAO, DAVIS, Ronald W, GOODSON, William H

“…Breast cancer outcome is highly variable. Whether inadvertent exposure to environmental xenobiotics evokes a biological response promoting cancer…”
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Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition by Zhang, Haiyu, Cohen, Adam L, Krishnakumar, Sujatha, Wapnir, Irene L, Veeriah, Selvaraju, Deng, Glenn, Coram, Marc A, Piskun, Caroline M, Longacre, Teri A, Herrler, Michael, Frimannsson, Daniel O, Telli, Melinda L, Dirbas, Frederick M, Matin, A C, Dairkee, Shanaz H, Larijani, Banafshe, Glinsky, Gennadi V, Bild, Andrea H, Jeffrey, Stefanie S

“…Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapies. Phosphatidylinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)…”
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Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis by KORKOLA, James E, DEVRIES, Sandy, FRIDLYAND, Jane, HWANG, E. Shelley, ESTEP, Anne L. H, CHEN, Yunn-Yi, CHEW, Karen L, DAIRKEE, Shanaz H, JENSEN, Ronald M, WALDMAN, Frederic M

“…Invasive lobular and ductal breast tumors have distinct histologies and clinical presentation. Other than altered expression of E-cadherin, little is known…”
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Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers by Yau, Christina, Fedele, Vita, Roydasgupta, Ritu, Fridlyand, Jane, Hubbard, Alan, Gray, Joe W, Chew, Karen, Dairkee, Shanaz H, Moore, Dan H, Schittulli, Francesco, Tommasi, Stefania, Paradiso, Angelo, Albertson, Donna G, Benz, Christopher C

“…Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age at diagnosis has been shown to be an…”
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Immutable Functional Attributes of Histologic Grade Revealed by Context-Independent Gene Expression in Primary Breast Cancer Cells by DAIRKEE, Shanaz H, SAYEED, Aejaz, LUCIANI, Gloria, CHAMPION, Stacey, ZHENHANG MENG, JAKKULA, Lakshmi R, FEILER, Heidi S, GRAY, Joe W, MOORE, Dan H

“…Inherent cancer phenotypes that are independent of fluctuating cross-talk with the surrounding tissue matrix are highly desirable candidates for targeting…”
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Biallelic inactivation of the thyroid hormone receptor β1 gene in early stage breast cancer by ZHENG LI, ZHEN HANG MENG, CHANDRASEKARAN, Raman, KUO, Wen-Lin, COLLINS, Colin C, GRAY, Joe W, DAIRKEE, Shanaz H

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The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers by CHEN, L.-C, MANJESHWAR, S, YOU LU, MOORE, D, LJUNG, B.-M, KUO, W.-L, DAIRKEE, S. H, WERNICK, M, COLLINS, C, SMITH, H. S

“…Amplification is a key mechanism whereby a cancer cell increases the message level of genes that confer a selective advantage when they are overexpressed. In…”
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