Search Results - "DAHLER, A. L"

Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible by POPA, C, DICKER, A. J, DAHLER, A. L, SAUNDERS, N. A

“…Retinoids, and their synthetic analogues, are well‐established regulators of the squamous differentiation programme both in vivo and in vitro. Despite this,…”
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E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes by DICKER, A. J, POPA, C, DAHLER, A. L, SEREWKO, M. M, HILDITCH-MAGUIRE, P. A, FRAZER, I. H, SAUNDERS, N. A

“…Squamous differentiation of keratinocytes is associated with decreases in E2F-1 mRNA expression and E2F activity, and these processes are disrupted in squamous…”
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E2F as a Regulator of Keratinocyte Proliferation: Implications for Skin Tumor Development by Jones, Susan J., Dicker, Anthony J., Dahler, Alison L., Saunders, Nicholas A.

“…E2F and DP family members are established regulators of the cell cycle. In this study, we examined their activity/expression during keratinocyte growth arrest…”
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Indole-3-carbinol - induced growth inhibition can be converted to a cytotoxic response in the presence of TPA+Ca(2+) in squamous cell carcinoma cell lines by Dahler, A L, Rickwood, D, Guminski, A, Teakle, N, Saunders, N A

“…We examined the possibility that I3C, when combined with a differentiation stimulus (TPA+CaCl(2)), would sensitise SCC cells to a differentiation stimulus. We…”
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E2F1 messenger RNA is destabilized in response to a growth inhibitor in normal human keratinocytes but not in a squamous carcinoma cell line by SAUNDERS, N. A, DICKER, A. J, JONES, S. J, DAHLER, A. L

“…Keratinocyte growth arrest is characterized by a reduction in the activity and expression of E2F1. Here, we examine the role posttranscriptional processing…”
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Histone Hyperacetylation Induced by Histone Deacetylase Inhibitors Is Not Sufficient to Cause Growth Inhibition in Human Dermal Fibroblasts by Brinkmann, Hannah, Dahler, Alison L., Popa, Claudia, Serewko, Magdalena M., Parsons, Peter G., Gabrielli, Brian G., Burgess, Andrew J., Saunders, Nicholas A.

“…Use of specific histone deacetylase inhibitors has revealed critical roles for the histone deacetylases (HDAC) in controlling proliferation. Although many…”
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Functional Characterization of Cultured Cells Derived from an Intraepidermal Carcinoma of the Skin (IEC-1) by Dicker, Anthony J., Serewko, Magdalena M., Dahler, Alison L., Khanna, Kum Kum, Kaur, Pritinder, Li, Amy, Strutton, Geoff M., Saunders, Nicholas A.

“…We have successfully isolated a cell line (IEC-1) from an intraepidermal carcinoma of the skin of a patient and compared its behavior, in vitro, to normal…”
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Indole‐3‐carbinol – Induced growth inhibition can be converted to a cytotoxic response in the presence of TPA + Ca2+ in squamous cell carcinoma cell lines by Dahler, A.L., Rickwood, D., Guminski, A., Teakle, N., Saunders, N.A.

“…We examined the possibility that I3C, when combined with a differentiation stimulus (TPA + CaCl2), would sensitise SCC cells to a differentiation stimulus. We…”
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Suppression of keratinocyte growth and differentiation by transforming growth factor beta1 involves multiple signaling pathways by Dahler, A L, Cavanagh, L L, Saunders, N A

“…Transforming growth factor beta1 treatment of keratinocytes results in a suppression of differentiation, an induction of extracellular matrix production, and a…”
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Alterations in gene expression and activity during squamous cell carcinoma development by SEREWKO, Magdalena M, POPA, Claudia, DAHLER, Alison L, SMITH, Louise, STRUTTON, Geoff M, COMAN, William, DICKER, Anthony J, SAUNDERS, Nicholas A

“…This study focuses on characterizing the genetic and biological alterations associated with squamous cell carcinoma development. Normal human epidermal…”
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Keratinocyte growth arrest is associated with activation of a transcriptional repressor element in the human cdk1 promoter by Dahler, Alison L., Jones, Susan J., Dicker, Anthony J., Saunders, Nicholas A.

“…In this study we examined the regulation of cdk1 expression in normal human epidermal keratinocytes (HEKs) and neoplastic keratinocytes. Keratinocytes were…”
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Indole-3-carbinol - Induced growth inhibition can be converted to a cytotoxic response in the presence of TPA+Ca super(2) super(+) in squamous cell carcinoma cell lines by Dahler, AL, Rickwood, D, Guminski, A, Teakle, N, Saunders, NA

“…We examined the possibility that I3C, when combined with a differentiation stimulus (TPA+CaCl sub(2)), would sensitise SCC cells to a differentiation stimulus…”
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Cytochrome P540, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible by Popa, C, Dicker, A J, Dahler, A L, Saunders, N A

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E2F suppression and Sp1 overexpression are sufficient to induce the differentiation-specific marker, transglutaminase type 1, in a squamous cell carcinoma cell line by CHUNG FAI WONG, BARNES, Liam M, DAHLER, Alison L, SMITH, Louise, POPA, Claudia, SEREWKO-AURET, Magdalena M, SAUNDERS, Nicholas A

“…Recently, E2F function has expanded to include the regulation of differentiation in human epidermal keratinocytes (HEKs). We extend these findings to report…”
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E2F modulates keratinocyte squamous differentiation: implications for E2F inhibition in squamous cell carcinoma by Wong, Chung Fai, Barnes, Liam M, Dahler, Alison L, Smith, Louise, Serewko-Auret, Magdalena M, Popa, Claudia, Abdul-Jabbar, Ibtissam, Saunders, Nicholas A

“…E2F regulation is essential for normal cell cycle progression. Therefore, it is not surprising that squamous cell carcinoma cell lines (SCC) overexpress E2F1…”
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AP-2 transcription factor family member expression, activity, and regulation in human epidermal keratinocytes in vitro by Popa, Claudia, Dahler, Alison L., Serewko-Auret, Magdalena M., Wong, Chung F., Smith, Louise, Barnes, Liam M., Saunders, Nicholas A., Strutton, Geoff M.

“…The AP-2 transcription factor family is presumed to play an important role in the regulation of the keratinocyte squamous differentiation program; however,…”
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Modulation of proliferation-specific and differentiation-specific markers in human keratinocytes by SMAD7 by Smith, Louise, Dahler, Alison L, Cavanagh, Lois L, Popa, Claudia, Barnes, Liam M, Serewko-Auret, Magdalena M.M, Fai Wong, C, Saunders, Nicholas A

“…We examined the potential role of SMAD7 in human epidermal keratinocyte differentiation. Overexpression of SMAD7 inhibited the activity of the…”
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Isolation (From a Basal Cell Carcinoma) of a Functionally Distinct Fibroblast-Like Cell Type that Overexpresses Ptch by Dicker, Anthony J., Serewko, Magdalena M., Russell, Terry, Dahler, Alison L., Saunders, Nicholas A., Rothnagel, Joseph A., Strutton, Geoff M.

“…In this study we report on the isolation and characterization of a nonepithelial, nontumorigenic cell type (BCC1) derived from a basal cell carcinoma from a…”
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