Search Results - "DAHA, Mohamed R"

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population by Gaya da Costa, Mariana, Poppelaars, Felix, van Kooten, Cees, Mollnes, Tom E, Tedesco, Francesco, Würzner, Reinhard, Trouw, Leendert A, Truedsson, Lennart, Daha, Mohamed R, Roos, Anja, Seelen, Marc A

“…The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better…”
Get full text

Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components by Kotimaa, Juha, Klar-Mohammad, Ngaisah, Gueler, Faikah, Schilders, Geurt, Jansen, Aswin, Rutjes, Helma, Daha, Mohamed R., van Kooten, Cees

“…•Functional activity of C3 and levels of initiation factors are similar in male and female mice.•Functional activity of C9, and serum levels of C6 and C9 is…”
Get full text

Dysregulation of Complement Activation and Placental Dysfunction: A Potential Target to Treat Preeclampsia? by Pierik, E, Prins, Jelmer R, van Goor, Harry, Dekker, Gustaaf A, Daha, Mohamed R, Seelen, Marc A J, Scherjon, Sicco A

“…Preeclampsia is one of the leading causes of maternal and neonatal mortality and morbidity worldwide, affecting 2-8% of all pregnancies. Studies suggest a link…”
Get full text

The Complement System in Dialysis: A Forgotten Story? by Poppelaars, Felix, Faria, Bernardo, Gaya da Costa, Mariana, Franssen, Casper F M, van Son, Willem J, Berger, Stefan P, Daha, Mohamed R, Seelen, Marc A

“…Significant advances have lead to a greater understanding of the role of the complement system within nephrology. The success of the first clinically approved…”
Get full text

The Contribution of Complement to the Pathogenesis of IgA Nephropathy: Are Complement-Targeted Therapies Moving from Rare Disorders to More Common Diseases? by Poppelaars, Felix, Faria, Bernardo, Schwaeble, Wilhelm, Daha, Mohamed R

“…Primary IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and kidney failure for which there is no disease-specific treatment. However, this…”
Get full text

Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pERK Signaling by Castellano, Giuseppe, Franzin, Rossana, Stasi, Alessandra, Divella, Chiara, Sallustio, Fabio, Pontrelli, Paola, Lucarelli, Giuseppe, Battaglia, Michele, Staffieri, Francesco, Crovace, Antonio, Stallone, Giovanni, Seelen, Marc, Daha, Mohamed R, Grandaliano, Giuseppe, Gesualdo, Loreto

“…Pericytes are one of the principal sources of scar-forming myofibroblasts in chronic kidneys disease. However, the modulation of pericyte-to-myofibroblast…”
Get full text

IL-10–producing macrophages preferentially clear early apoptotic cells by Xu, Wei, Roos, Anja, Schlagwein, Nicole, Woltman, Andrea M., Daha, Mohamed R., van Kooten, Cees

“…Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage…”
Get full text

Risk Alleles in CFH and ARMS2 Are Independently Associated with Systemic Complement Activation in Age-related Macular Degeneration by Smailhodzic, Dzenita, MD, Klaver, Caroline C.W., MD, PhD, Klevering, B. Jeroen, MD, PhD, Boon, Camiel J.F., MD, PhD, Groenewoud, Joannes M.M., MSc, Kirchhof, Bernd, MD, PhD, Daha, Mohamed R., PhD, den Hollander, Anneke I., PhD, Hoyng, Carel B., MD, PhD

“…Purpose Systemic complement activation is associated with age-related macular degeneration (AMD) and has mainly been attributed to a risk allele in the…”
Get full text

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia‐reperfusion injury by Poppelaars, Felix, Werkhoven, Maaike B., Kotimaa, Juha, Veldhuis, Zwanida J., Ausema, Albertina, Broeren, Stefan G. M., Damman, Jeffrey, Hempel, Julia C., Leuvenink, Henri G. D., Daha, Mohamed R., Son, Willem J., Kooten, Cees, Os, Ronald P., Hillebrands, Jan‐Luuk, Seelen, Marc A.

“…ABSTRACT The complement system, and specifically C5a, is involved in renal ischemia‐reperfusion (IR) injury. The 2 receptors for complement anaphylatoxin C5a…”
Get full text

Therapeutic Targeting of Classical and Lectin Pathways of Complement Protects from Ischemia-Reperfusion-Induced Renal Damage by Castellano, Giuseppe, Melchiorre, Rita, Loverre, Antonia, Ditonno, Pasquale, Montinaro, Vincenzo, Rossini, Michele, Divella, Chiara, Battaglia, Michele, Lucarelli, Giuseppe, Annunziata, Gennaro, Palazzo, Silvano, Selvaggi, Francesco Paolo, Staffieri, Francesco, Crovace, Antonio, Daha, Mohamed R, Mannesse, Maurice, van Wetering, Sandra, Paolo Schena, Francesco, Grandaliano, Giuseppe

“…Ischemia-reperfusion injury is the major cause of delayed graft function in transplanted kidneys, an early event significantly affecting long-term graft…”
Get full text

‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development by Mastellos, Dimitrios C., Blom, Anna M., Connolly, E. Sander, Daha, Mohamed R., Geisbrecht, Brian V., Ghebrehiwet, Berhane, Gros, Piet, Hajishengallis, George, Holers, V. Michael, Huber-Lang, Markus, Kinoshita, Taroh, Mollnes, Tom E., Montgomery, Robert A., Morgan, B. Paul, Nilsson, Bo, Pio, Ruben, Ricklin, Daniel, Risitano, Antonio M., Taylor, Ronald P., Mantovani, Alberto, Ioannidis, John P. A., Lambris, John D.

“…Therapeutic innovations of potentially great clinical impact should embrace the overarching values of research accountability, data transparency and validation…”
Get full text

Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels by Ristau, Tina, Paun, Constantin, Ersoy, Lebriz, Hahn, Moritz, Lechanteur, Yara, Hoyng, Carel, de Jong, Eiko K, Daha, Mohamed R, Kirchhof, Bernd, den Hollander, Anneke I, Fauser, Sascha

“…Age-related macular degeneration (AMD) is a common condition that leads to severe vision loss and dysregulation of the complement system is thought to be…”
Get full text

Soluble CD59 in peritoneal dialysis: a potential biomarker for peritoneal membrane function by Faria, Bernardo, Gaya da Costa, Mariana, Lima, Carla, Willems, Loek, Brandwijk, Ricardo, Berger, Stefan P., Daha, Mohamed R., Pestana, Manuel, Seelen, Marc A., Poppelaars, Felix

“…Introduction Various studies have reported the importance of complement regulators in preventing mesothelial damage during peritoneal dialysis (PD). Its…”
Get full text

Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement Activation by Xu, Wei, Berger, Stefan P, Trouw, Leendert A, de Boer, Hetty C, Schlagwein, Nicole, Mutsaers, Chantal, Daha, Mohamed R, van Kooten, Cees

“…Cells that undergo apoptosis or necrosis are promptly removed by phagocytes. Soluble opsonins such as complement can opsonize dying cells, thereby promoting…”
Get full text

Allergy is a protective factor against age-related macular degeneration by Ristau, Tina, Ersoy, Lebriz, Lechanteur, Yara, den Hollander, Anneke I, Daha, Mohamed R, Hahn, Moritz, Hoyng, Carel B, Fauser, Sascha

“…To investigate the role of allergy on AMD. Age-related macular degeneration staging was performed for 3585 individuals (1878 from Cologne, Germany, and 1707…”
Get full text

Complement Therapeutics in the Multi-Organ Donor: Do or Don't? by van Zanden, Judith E, Jager, Neeltina M, Daha, Mohamed R, Erasmus, Michiel E, Leuvenink, Henri G D, Seelen, Marc A

“…Over the last decade, striking progress has been made in the field of organ transplantation, such as better surgical expertise and preservation techniques…”
Get full text

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20 by Lammerts, Rosa G M, Talsma, Ditmer T, Dam, Wendy A, Daha, Mohamed R, Seelen, Marc A J, Berger, Stefan P, van den Born, Jacob

“…Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin…”
Get full text

Role of complement in innate immunity and infections by Daha, Mohamed R

“…The complement system is a major player in our innate defense and constitutes one of the key effector mechanisms of antibody-dependent and -independent…”
Get full text

Memories of Bob Sim-Genius Complementologist and Cheerful Travel Companion by Würzner, Reinhard, Tedesco, Francesco, Garred, Peter, Mollnes, Tom E, Truedsson, Lennart, Turner, Malcolm W, Sommarin, Yngve, Wieslander, Jörgen, Daha, Mohamed R

“…Shortly before his 70th birthday, Robert B [...]…”
Get full text

Intradialytic Complement Activation Precedes the Development of Cardiovascular Events in Hemodialysis Patients by Poppelaars, Felix, Gaya da Costa, Mariana, Faria, Bernardo, Berger, Stefan P, Assa, Solmaz, Daha, Mohamed R, Medina Pestana, José Osmar, van Son, Willem J, Franssen, Casper F M, Seelen, Marc A

“…Hemodialysis (HD) is a life-saving treatment for patients with end stage renal disease. However, HD patients have markedly increased rates of cardiovascular…”
Get full text