Search Results - "DA CRUZ E SILVA, EDGAR F."

An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model by Korrodi-Gregório, Luís, Margarida Lopes, Ana, Esteves, Sara L C, Afonso, Sandra, Lemos de Matos, Ana, Lissovsky, Andrey A, da Cruz e Silva, Odete A B, da Cruz e Silva, Edgar F, Esteves, Pedro José, Fardilha, Margarida

“…T-complex testis expressed protein 1 domain containing 4 (TCTEX1D4) contains the canonical phosphoprotein phosphatase 1 (PPP1) binding motif, composed by the…”
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Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease by da Cruz e Silva, Odete A B, Henriques, Ana Gabriela, Domingues, Sara Catarina Timóteo Santos, da Cruz e Silva, Edgar F

“…One of the most important contributions to our understanding of neurodegenerative diseases in the last decade has been the demonstration that several disorders…”
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Identification of the human testis protein phosphatase 1 interactome by Fardilha, Margarida, Esteves, Sara L.C., Korrodi-Gregório, Luís, Vintém, Ana Paula, Domingues, Sara C., Rebelo, Sandra, Morrice, Nick, Cohen, Patricia T.W., Silva, Odete A.B. da Cruz e, Silva, Edgar F. da Cruz e

“…Protein phosphorylation is a critical regulatory mechanism in cellular signalling. To this end, PP1 is a major eukaryotic serine/threonine-specific phosphatase…”
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The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate by Santos, Mariana, Rebelo, Sandra, Van Kleeff, Paula J M, Kim, Connie E, Dauer, William T, Fardilha, Margarida, da Cruz E Silva, Odete A, da Cruz E Silva, Edgar F

“…Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and…”
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Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated by Vieira, Sandra I, Rebelo, Sandra, Esselmann, Hermann, Wiltfang, Jens, Lah, James, Lane, Rachel, Small, Scott A, Gandy, Sam, da Cruz E Silva, Edgar F, da Cruz E Silva, Odete Ab

“…Retrograde transport of several transmembrane proteins from endosomes to the trans-Golgi network (TGN) occurs via Rab 5-containing endosomes, mediated by…”
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Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation by Santos, Mariana, Domingues, Sara C, Costa, Patrícia, Muller, Thorsten, Galozzi, Sara, Marcus, Katrin, da Cruz e Silva, Edgar F, da Cruz e Silva, Odete A, Rebelo, Sandra

“…Lamina associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear membrane that is ubiquitously expressed. LAP1 binds to lamins and chromatin,…”
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SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein by Browne, Gareth J, Fardilha, Margarida, Oxenham, Senga K, Wu, Wenjuan, Helps, Nicholas R, da Cruz E Silva, Odete A B, Cohen, Patricia T W, da Cruz E Silva, Edgar F

“…PP1 (protein phosphatase 1) is a ubiquitously expressed serine/threonine-specific protein phosphatase whose activity towards different substrates appears to be…”
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TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network by Korrodi-Gregório, Luís, Vieira, Sandra I, Esteves, Sara L C, Silva, Joana V, Freitas, Maria João, Brauns, Ann-Kristin, Luers, Georg, Abrantes, Joana, Esteves, Pedro J, da Cruz E Silva, Odete A B, Fardilha, Margarida, da Cruz E Silva, Edgar F

“…Reversible phosphorylation plays an important role as a mechanism of intracellular control in eukaryotes. PPP1, a major eukaryotic Ser/Thr-protein phosphatase,…”
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Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa by Korrodi-Gregório, Luis, Ferreira, Mónica, Vintém, Ana Paula, Wu, Wenjuan, Muller, Thorsten, Marcus, Katrin, Vijayaraghavan, Srinivasan, Brautigan, David L, da Cruz E Silva, Odete A B, Fardilha, Margarida, da Cruz E Silva, Edgar F

“…Protein Ser/Thr Phosphatase PPP1CC2 is an alternatively spliced isoform of PPP1C that is highly enriched in testis and selectively expressed in sperm. Addition…”
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Alternative Splicing Controls Nuclear Translocation of the Cell Cycle-regulated Nek2 Kinase by Wu, Wenjuan, Baxter, Joanne E., Wattam, Samantha L., Hayward, Daniel G., Fardilha, Margarida, Knebel, Axel, Ford, Eleanor M., da Cruz e Silva, Edgar F., Fry, Andrew M.

“…Nek2 is a cell cycle-regulated serine/threonine protein kinase that is up-regulated in human cancers. Functionally, it is implicated in control of centrosome…”
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Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform by Domingues, Sara Catarina, Henriques, Ana Gabriela, Fardilha, Margarida, da Cruz e Silva, Edgar F., da Cruz e Silva, Odete A.B.

“…J. Neurochem. (2011) 119, 1086–1098. Fe65 is a multimodular adaptor protein that interacts with the cytosolic domain of the β‐amyloid precursor protein (APP),…”
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Progesterone regulates the phosphorylation of protein phosphatases in the brain by Amorim, Miguel A.R., Guerra-Araiza, Christian, Pernía, Olga, da Cruz e Silva, Edgar F., Garcia-Segura, Luis M.

“…Previous studies have shown that progesterone modulates the activity of different kinases and the phosphorylation of Tau in the brain. These actions of…”
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"Omics" of human sperm: profiling protein phosphatases by Fardilha, Margarida, Ferreira, Mónica, Pelech, Steven, Vieira, Sandra, Rebelo, Sandra, Korrodi-Gregorio, Luís, Sousa, Mário, Barros, Alberto, Silva, Vladimiro, da Cruz e Silva, Odete A B, da Cruz e Silva, Edgar F

“…Phosphorylation is a major regulatory mechanism in eukaryotic cells performed by the concerted actions of kinases and phosphatases (PPs). Protein…”
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Protein phosphatase 1 is a key player in nuclear events by Rebelo, Sandra, Santos, Mariana, Martins, Filipa, da Cruz e Silva, Edgar F., da Cruz e Silva, Odete A.B.

“…Reversible protein phosphorylation at serine (Ser), threonine (Thr) and tyrosine (Tyr) residues is among the major regulatory mechanism in eukaryotic cells…”
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Altered Subcellular Distribution of the Alzheimer's Amyloid Precursor Protein Under Stress Conditions by DOMINGUES, SARA C.T.S., HENRIQUES, ANA GABRIELA, WU, WENJUAN, Da CRUZ e SILVA, EDGAR F., Da CRUZ e SILVA, ODETE A.B.

“…:  Altered metabolism of the Alzheimer's amyloid precursor protein (APP) appears to be a key event in the pathogenesis of Alzheimer's disease (AD), and both…”
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Intracellular sAPP retention in response to Aβ is mapped to cytoskeleton-associated structures by Henriques, Ana Gabriela, Vieira, Sandra Isabel, Crespo-López, Maria Elena, Guiomar de Oliveira, Márcio A., da Cruz e Silva, Edgar F., da Cruz e Silva, Odete A.B.

“…Amyloid β (Aβ) contributes to neurodegeneration in Alzheimer's disease and provides a close association between molecular events and pathology, although the…”
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Protein phosphorylation and APP metabolism by DA CRUZ E SILVA, Edgar F, DA CRUZ E SILVA, Odete A. B

“…Numerous lines of evidence place signal transduction cascades at the core of many processes having a direct role in neurodegeneration and associated disorders…”
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BRI2 and BRI3 are functionally distinct phosphoproteins by Martins, Filipa, Rebelo, Sandra, Santos, Mariana, Cotrim, Cândida Zita, da Cruz e Silva, Edgar F., da Cruz e Silva, Odete A.B.

“…Three BRI protein family members have been identified. Among these are BRI3 and BRI2, the latter is associated with Familial Danish and Familial British…”
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Aβ promotes Alzheimer's disease-like cytoskeleton abnormalities with consequences to APP processing in neurons by Henriques, Ana Gabriela, Vieira, Sandra Isabel, da Cruz e Silva, Edgar F, da Cruz e Silva, Odete A.B

“…J. Neurochem. (2010) 113, 761-771. Aβ is proteolytically produced from the Alzheimer's amyloid precursor protein (APP). Major properties attributed to Aβ…”
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Genetic mutations strengthen functional association of LAP1 with DYT1 dystonia and muscular dystrophy by Rebelo, Sandra, da Cruz e Silva, Edgar F., da Cruz e Silva, Odete A.B.

“…Lamina-associated polypeptide 1 (LAP1) is a ubiquitously expressed integral protein of the inner nuclear membrane. It interacts physically with lamins,…”
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