Search Results - "DA'DARA, A. A."

Schistosome migration in the definitive host by Nation, Catherine S, Da'dara, Akram A, Marchant, Jeffrey K, Skelly, Patrick J

“…Schistosomes are parasitic blood flukes that infect >200 million people around the world. Free-swimming larval stages penetrate the skin, invade a blood…”
Get full text

Schistosome immunomodulators by Acharya, Sreemoyee, Da'dara, Akram A, Skelly, Patrick J

“…Schistosomes are long lived, intravascular parasitic platyhelminths that infect >200 million people globally. The molecular mechanisms used by these blood…”
Get full text

The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin by Wang, Qiang, Da’dara, Akram A., Skelly, Patrick J.

“…Schistosomes are intravascular, parasitic flatworms that cause debilitating disease afflicting >200 million people. Proteins expressed at the host-parasite…”
Get full text

Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase from Schistosoma mansoni , a Platyhelminth Parasite Responsible for Schistosomiasis by Angeli, Andrea, Pinteala, Mariana, Maier, Stelian S, Simionescu, Bogdan C, Da'dara, Akram A, Skelly, Patrick J, Supuran, Claudiu T

“…Schistosomiasis is a debilitating infection provoked by parasitic flatworms called schistosomes. The species is endemic in Africa, where it causes intestinal…”
Get full text

Metabolism of FAD, FMN and riboflavin (vitamin B2) in the human parasitic blood fluke Schistosoma mansoni by Da'dara, Akram A, Nation, Catherine S, Skelly, Patrick J

“…Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma. The intravascular worms acquire the nutrients necessary for their…”
Get full text

A novel, non-neuronal acetylcholinesterase of schistosome parasites is essential for definitive host infection by Skelly, Patrick J, Da'dara, Akram A

“…Schistosomes are long-lived parasitic worms that infect >200 million people globally. The intravascular life stages are known to display acetylcholinesterase…”
Get full text

Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides by Angeli, Andrea, Ferraroni, Marta, Da’dara, Akram A, Selleri, Silvia, Pinteala, Mariana, Carta, Fabrizio, Skelly, Patrick J, Supuran, Claudiu T

“…Tegumental carbonic anhydrase from the worm Schistosoma mansoni (SmCA) is considered a new anti-parasitic target because suppressing its expression interferes…”
Get full text

Multifunctional Fructose 1,6-Bisphosphate Aldolase as a Therapeutic Target by Pirovich, David B, Da'dara, Akram A, Skelly, Patrick J

“…Fructose 1,6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the fourth step of glycolysis. Aldolases are classified into three groups:…”
Get full text

GLYCOLYTIC ENZYMES AS VACCINES AGAINST SCHISTOSOMIASIS: TESTING SCHISTOSOMA MANSONI PHOSPHOGLYCERATE MUTASE IN MICE by Pirovich, David B, Da'dara, Akram A, Skelly, Patrick J

“…Schistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for…”
Get more information

Schistosomes Enhance Plasminogen Activation: The Role of Tegumental Enolase by Figueiredo, Barbara C, Da'dara, Akram A, Oliveira, Sergio C, Skelly, Patrick J

“…Schistosoma mansoni is a blood fluke parasite that causes schistosomiasis, a debilitating disease of global public health importance. These relatively large…”
Get full text

Maturation of Dendritic Cell 2 Phenotype by a Helminth Glycan Uses a Toll-Like Receptor 4-Dependent Mechanism by Thomas, Paul G, Carter, Michele R, Atochina, Olga, Da'Dara, Akram A, Piskorska, Danuta, McGuire, Edward, Harn, Donald A

“…The biology of pathogen-associated molecular patterns (PAMPs) stimulating APCs to differentiate into a Th1-promoting phenotype has been well characterized…”
Get full text

Schistosome feeding and regurgitation by Skelly, Patrick J, Da'dara, Akram A, Li, Xiao-Hong, Castro-Borges, William, Wilson, R Alan

“…Schistosomes are parasitic flatworms that infect >200 million people worldwide, causing the chronic, debilitating disease schistosomiasis. Unusual among…”
Get full text

Vitamin B6 Acquisition and Metabolism in Schistosoma mansoni by Da'dara, Akram A, Elzoheiry, Manal, El-Beshbishi, Samar N, Skelly, Patrick J

“…Schistosomes are parasitic platyhelminths that currently infect >200 million people globally. The adult worms can live within the vasculature of their hosts…”
Get full text

Schistosomes versus platelets by Da’dara, Akram A, Skelly, Patrick J

“…Abstract Schistosomes are parasitic platyhelminths that currently infect > 200 million people and cause the chronic debilitating disease schistosomiasis. While…”
Get full text

Gene suppression in schistosomes using RNAi by Da'dara, Akram A, Skelly, Patrick J

“…Schistosomiasis is a neglected tropical disease responsible for the death of more than 300,000 people every year. The disease is caused by intravascular…”
Get more information

Schistosomes Impede ATP-Induced T Cell Apoptosis In Vitro: The Role of Ectoenzyme SmNPP5 by Nation, Catherine S, Da'dara, Akram A, Elzoheiry, Manal, Skelly, Patrick J

“…Schistosomes (blood flukes) can survive in the bloodstream of their hosts for many years. We hypothesize that proteins on their host-interactive surface…”
Get full text

Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins by Krautz-Peterson, Greice, Debatis, Michelle, Tremblay, Jacqueline M, Oliveira, Sergio C, Da'dara, Akram A, Skelly, Patrick J, Shoemaker, Charles B

“…Schistosomiasis is a major disease of the developing world for which no vaccine has been successfully commercialized. While numerous Schistosoma mansoni worm…”
Get full text

The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin by Wang, Qiang, Da'dara, Akram A, Skelly, Patrick J

“…Schistosomes are blood dwelling parasitic worms that cause the debilitating disease schistosomiasis. Here we examined the influence of the parasites on their…”
Get full text

Schistosomes can hydrolyze proinflammatory and prothrombotic polyphosphate (polyP) via tegumental alkaline phosphatase, SmAP by Elzoheiry, Manal, Da’dara, Akram A., Nation, Catherine S., El-Beshbishi, Samar N., Skelly, Patrick J.

“…[Display omitted] •Schistosoma mansoni is a long-lived intravascular trematode parasite.•Intravascular life stages (schistosomula, adult males & females) can…”
Get full text

Schistosoma mansoni phosphoglycerate mutase: a glycolytic ectoenzyme with thrombolytic potential by Pirovich, David B., Da’dara, Akram A., Skelly, Patrick J.

“…Schistosomiasis is a debilitating parasitic disease caused by intravascular flatworms called schistosomes (blood flukes) that affects >200 million people…”
Get full text