Is microbiota characterization a useful tool in clinical practice? An exploratory analysis of patients from the IBS – constant-care e-health monitoring initiative

Objective: Intestinal microbiota are prominent in the etiology of irritable bowel syndrome (IBS). In this exploratory study, we investigated short- and long-term changes in the microbiota of IBS patients after intervening with a low-FODMAP diet (LFD) or 8-strains probiotics (Bifidobacterium, Lactoba...

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Bibliographic Details
Published in:	Microbiota in health and disease Vol. 5
Main Authors:	M. Qais Al-sheikh, D. Vedel Ankersen, M. Bennedsen, C. Casén, K. Gravdal, G. Kirubakaran, J. Burisch, P. Munkholm
Format:	Journal Article
Language:	English
Published:	Verduci Editore 01-11-2023
Subjects:	dysbiosis irritable bowel syndrome (ibs) low-fodmap diet (lfd) microbiota probiotics
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Summary:	Objective: Intestinal microbiota are prominent in the etiology of irritable bowel syndrome (IBS). In this exploratory study, we investigated short- and long-term changes in the microbiota of IBS patients after intervening with a low-FODMAP diet (LFD) or 8-strains probiotics (Bifidobacterium, Lactobacillus and Streptococcus) using a standardized microbiota characterization test intended for routine use. Materials and Methods: We analyzed data and fecal samples collected in a previous trial from non-comorbid IBS patients before treatment, and then again after four weeks and one year of treatment. Response to treatment was defined by a reduction in the IBS-SSS score, and the gut microbiota were characterized using the standardized and CE-marked GA-map® Dysbiosis Test Lx. Results: Of the 25 responders to either treatment, two of the 22 with fecal samples available were dysbiotic at baseline, increasing to eight out of 19 after four weeks; after one year all responders providing a sample were normobiotic (n=15). After four weeks, the abundance of Bacilli, Lactobacillus spp. and Streptococcus salivarius ssp. thermophilus were temporarily increased in the 8-strains probiotics responder group (p<.05), while for LFD responders Anaerobutyricum hallii had decreased. There was a greater abundance of Ruminococcus gnavus at baseline in those responding to probiotics than in those responding to LFD. Conclusions: In addition to improving IBS symptoms, sustained LFD or repeat 8-strains probiotics tended to temporarily alter the microbiota profile in responders. Microbiota characterization is a promising tool for monitoring IBS treatments; however, more extensive studies in treatment and monitoring are needed.
ISSN:	2704-8845
DOI:	10.26355/mhd_202311_948