Search Results - "D. C. Gonçalves"
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Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant
Published in Molecules (Basel, Switzerland) (29-03-2020)“…Medicinal use of L. has an extensive history and it was essential in the discovery of phytocannabinoids, including the major psychoactive…”
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2
Citral Inhibits the Inflammatory Response and Hyperalgesia in Mice: The Role of TLR4, TLR2/Dectin-1, and CB2 Cannabinoid Receptor/ATP-Sensitive K+ Channel Pathways
Published in Journal of natural products (Washington, D.C.) (24-04-2020)“…Citral ((2E)-3,7-dimethylocta-2,6-dienal), a bioactive component of lemongrass, inhibits oxidant activity, nuclear factor kappa B (NF-κB) activation, and…”
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3
The Radial Point Interpolation Method combined with a bi-directional structural topology optimization algorithm
Published in Engineering with computers (01-12-2022)“…Projecting reduced-weight components with increased performance is a continuous engineering challenge, especially in the aircraft industry, where fuel…”
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Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model
Published in Cellular and molecular neurobiology (2021)“…Complex regional pain syndrome type-I (CRPS-I) is a chronic painful condition resulting from trauma. Bradykinin (BK) is an important inflammatory mediator…”
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Dopaminergic Receptors as Neuroimmune Mediators in Experimental Autoimmune Encephalomyelitis
Published in Molecular neurobiology (01-11-2021)“…The dopaminergic system plays an essential role in maintaining homeostasis between the central nervous system (CNS) and the immune system. Previous studies…”
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Topology optimization of light structures using the natural neighbour radial point interpolation method
Published in Meccanica (Milan) (01-03-2022)“…In this work, a bi-directional evolutionary topology optimization algorithm capable of reinforcing the structure at critical high stress regions is combined…”
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Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior
Published in Frontiers in neuroscience (10-02-2021)“…Obesity is a multifactorial disease, which in turn contributes to the onset of comorbidities, such as diabetes and atherosclerosis. Moreover, there are only…”
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The Ogden model and the natural neighbour radial point interpolation method for hyperelastic analyses
Published in Journal of the Brazilian Society of Mechanical Sciences and Engineering (2023)“…Hyperelastic behaviour can be observed in rubber-like materials and biological tissues. Different hyperelastic models have been developed, the neo-Hookean,…”
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Effects of Simvastatin Beyond Dyslipidemia: Exploring Its Antinociceptive Action in an Animal Model of Complex Regional Pain Syndrome-Type I
Published in Frontiers in pharmacology (04-09-2017)“…Simvastatin is a lipid-lowering agent that blocks the production of cholesterol through inhibition of 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase…”
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10
Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis
Published in Scientific reports (18-05-2017)“…In order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adjuvant properties of a non-toxic derivative of Escherichia…”
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Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release
Published in Neurotoxicology (Park Forest South) (01-09-2015)“…•Cannabidiol prevented cocaine-induced seizures in mice.•CB1 and CB2 antagonists failed to prevent cannabidiol effects.•Cocaine increases, whereas cannabidiol…”
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Involvement of Opioid System and TRPM8/TRPA1 Channels in the Antinociceptive Effect of Spirulina platensis
Published in Biomolecules (Basel, Switzerland) (17-04-2021)“…is a "super-food" and has attracted researchers' attention due to its anti-inflammatory, antioxidant, and analgesic properties. Herein, we investigated the…”
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Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor
Published in Biomolecules (Basel, Switzerland) (20-05-2020)“…Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress and genetic…”
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14
Long life tomato (Solanum Lycopersicum): price is quality?
Published in Scientific electronic archives (10-10-2019)“…The commercialization of the tomato has significant relevance in the national and international market. Thus, the purpose of this paper was to elucidate if the…”
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Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases
Published in Frontiers in pharmacology (23-02-2018)“…Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for…”
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16
Discrimination between normal and glaucomatous eyes with visual field and scanning laser polarimetry measurements
Published in British journal of ophthalmology (01-05-2001)“…AIM To evaluate the ability of structural parameters (as determined by retinal nerve fibre layer (RNFL) measurements obtained with the scanning laser…”
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Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon‐γ recovery and reduction of lung injury
Published in Immunology (01-09-2004)“…Summary A DNA vaccine based on the heat‐shock protein 65 Mycobacterium leprae gene (pHSP65) presented a prophylactic and therapeutic effect in an experimental…”
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18
Health‐related quality of life in patients with generalized pustular psoriasis: A systematic literature review
Published in Journal of the European Academy of Dermatology and Venereology (01-02-2024)“…Generalized pustular psoriasis (GPP) is a rare, chronic, neutrophilic inflammatory skin disease characterized by episodes of widespread eruption of sterile,…”
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19
Corrosion of Al 7075 alloy during the production of aeronautic components: Influence of process parameters at the deburring stage
Published in Materials and corrosion (01-12-2013)“…Aluminum alloys of the 7XXX series are widely used in aircraft applications. During the manufacturing of aeronautic components, the parts pass through four…”
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Exercise training reduces PGE2 levels and induces recovery from steatosis in tumor-bearing rats
Published in Hormone and metabolic research (01-12-2010)“…The effects of endurance training on PGE (2) levels and upon the maximal activity of hepatic carnitine palmitoyltransferase (CPT) system were studied in rats…”
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