Search Results - "D’arena, Giovanni"

The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia by Brusa, Davide, Serra, Sara, Coscia, Marta, Rossi, Davide, D'Arena, Giovanni, Laurenti, Luca, Jaksic, Ozren, Fedele, Giorgio, Inghirami, Giorgio, Gaidano, Gianluca, Malavasi, Fabio, Deaglio, Silvia

“…Chronic lymphocytic leukemia is marked by profound defects in T-cell function. Programmed death-1 is a receptor involved in tumor-mediated immunosuppression…”
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The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis by Giudice, Aldo, Crispo, Anna, Grimaldi, Maria, Polo, Andrea, Bimonte, Sabrina, Capunzo, Mario, Amore, Alfonso, D'Arena, Giovanni, Cerino, Pellegrino, Budillon, Alfredo, Botti, Gerardo, Costantini, Susan, Montella, Maurizio

“…In mammals, a master clock is located within the suprachiasmatic nucleus (SCN) of the hypothalamus, a region that receives input from the retina that is…”
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Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter’s syndrome: therapeutic implications by Arruga, Francesca, Bracciamà, Valeria, Vitale, Nicoletta, Vaisitti, Tiziana, Gizzi, Katiuscia, Yeomans, Alison, Coscia, Marta, D’Arena, Giovanni, Gaidano, Gianluca, Allan, John N., Furman, Richard R., Packham, Graham, Forconi, Francesco, Deaglio, Silvia

“…NOTCH1 mutations in chronic lymphocytic leukemia (CLL) lead to accumulation of NOTCH1 intracellular domain (NICD) and prolong signaling. These mutations…”
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High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders by Caivano, Antonella, Laurenzana, Ilaria, De Luca, Luciana, La Rocca, Francesco, Simeon, Vittorio, Trino, Stefania, D’Auria, Fiorella, Traficante, Antonio, Maietti, Maddalena, Izzo, Tiziana, D’Arena, Giovanni, Mansueto, Giovanna, Pietrantuono, Giuseppe, Laurenti, Luca, Musto, Pellegrino, Del Vecchio, Luigi

“…Many cell types release extracellular vesicles (EVs), including exosomes, microvesicles (MVs), and apoptotic bodies, which play a role in physiology and…”
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The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy by Arruga, Francesca, Rubin, Marta, Papazoglou, Despoina, Iannello, Andrea, Ioannou, Nikolaos, Moia, Riccardo, Rossi, Davide, Gaidano, Gianluca, Coscia, Marta, Laurenti, Luca, D'Arena, Giovanni, Allan, John N, Furman, Richard R, Vaisitti, Tiziana, Ramsay, Alan G, Deaglio, Silvia

“…T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory checkpoint receptor that negatively regulates Tcell responses. CD226 competes with…”
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SF3B1 -mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation by Pozzo, Federico, Bittolo, Tamara, Tissino, Erika, Vit, Filippo, Vendramini, Elena, Laurenti, Luca, D'Arena, Giovanni, Olivieri, Jacopo, Pozzato, Gabriele, Zaja, Francesco, Chiarenza, Annalisa, Di Raimondo, Francesco, Zucchetto, Antonella, Bomben, Riccardo, Rossi, Francesca Maria, Del Poeta, Giovanni, Dal Bo, Michele, Gattei, Valter

“…Chronic lymphocytic leukemia (CLL) is characterized by a low CD20 expression, in part explained by an epigenetic-driven downregulation triggered by mutations…”
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Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network by AUDRITO, Valentina, VAISITTI, Tiziana, ROSSI, Davide, GOTTARDI, Daniela, D'ARENA, Giovanni, LAURENTI, Luca, GAIDANO, Gianluca, MALAVASI, Fabio, DEAGLIO, Silvia

“…Because of its relatively indolent clinical course, chronic lymphocytic leukemia (CLL) offers a versatile model for testing novel therapeutic regimens and drug…”
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CD49d promotes disease progression in chronic lymphocytic leukemia: new insights from CD49d bimodal expression by Tissino, Erika, Pozzo, Federico, Benedetti, Dania, Caldana, Chiara, Bittolo, Tamara, Rossi, Francesca Maria, Bomben, Riccardo, Nanni, Paola, Chivilò, Hillarj, Cattarossi, Ilaria, Zaina, Eva, Norris, Kevin, Polesel, Jerry, Gentile, Massimo, Tripepi, Giovanni, Moia, Riccardo, Santinelli, Enrico, Innocenti, Idanna, Olivieri, Jacopo, D'Arena, Giovanni, Laurenti, Luca, Zaja, Francesco, Pozzato, Gabriele, Chiarenza, Annalisa, Di Raimondo, Francesco, Rossi, Davide, Pepper, Chris, Hartmann, Tanja Nicole, Gaidano, Gianluca, Del Poeta, Giovanni, Gattei, Valter, Zucchetto, Antonella

“…CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is…”
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NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia by Bonato, Alice, Chakraborty, Supriya, Bomben, Riccardo, Canarutto, Giulia, Felician, Giulia, Martines, Claudio, Zucchetto, Antonella, Pozzo, Federico, Vujovikj, Marija, Polesel, Jerry, Chiarenza, Annalisa, Del Principe, Maria Ilaria, Del Poeta, Giovanni, D’Arena, Giovanni, Marasca, Roberto, Tafuri, Agostino, Laurenti, Luca, Piazza, Silvano, Dimovski, Aleksandar J., Gattei, Valter, Efremov, Dimitar G.

“…Loss-of-function mutations in NFKBIE, which encodes for the NF-κB inhibitor IκBε, are frequent in chronic lymphocytic leukemia (CLL) and certain other B-cell…”
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TP53 Mutations with Low Variant Allele Frequency Predict Short Survival in Chronic Lymphocytic Leukemia by Bomben, Riccardo, Rossi, Francesca Maria, Vit, Filippo, Bittolo, Tamara, D'Agaro, Tiziana, Zucchetto, Antonella, Tissino, Erika, Pozzo, Federico, Vendramini, Elena, Degan, Massimo, Zaina, Eva, Cattarossi, Ilaria, Varaschin, Paola, Nanni, Paola, Berton, Michele, Braida, Alessandra, Polesel, Jerry, Cohen, Jared A, Santinelli, Enrico, Biagi, Annalisa, Gentile, Massimo, Morabito, Fortunato, Fronza, Gilberto, Pozzato, Gabriele, D'Arena, Giovanni, Olivieri, Jacopo, Bulian, Pietro, Pepper, Chris, Hockaday, Anna, Schuh, Anna, Hillmen, Peter, Rossi, Davide, Chiarenza, Annalisa, Zaja, Francesco, Di Raimondo, Francesco, Del Poeta, Giovanni, Gattei, Valter

“…In chronic lymphocytic leukemia (CLL), mutations are associated with reduced survival and resistance to standard chemoimmunotherapy (CIT). Nevertheless, the…”
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Correction: Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter’s syndrome: therapeutic implications by Arruga, Francesca, Bracciamà, Valeria, Vitale, Nicoletta, Vaisitti, Tiziana, Gizzi, Katiuscia, Yeomans, Alison, Coscia, Marta, D’Arena, Giovanni, Gaidano, Gianluca, Allan, John N., Furman, Richard R., Packham, Graham, Forconi, Francesco, Deaglio, Silvia

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response by Bologna, Cinzia, Buonincontri, Roberta, Serra, Sara, Vaisitti, Tiziana, Audrito, Valentina, Brusa, Davide, Pagnani, Andrea, Coscia, Marta, D'Arena, Giovanni, Mereu, Elisabetta, Piva, Roberto, Furman, Richard R, Rossi, Davide, Gaidano, Gianluca, Terhorst, Cox, Deaglio, Silvia

“…Chronic lymphocytic leukemia (CLL) is a variable disease; therefore, markers to identify aggressive forms are essential for patient management. Here, we have…”
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CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance by D'Arena, Giovanni, De Feo, Vincenzo, Pietrantuono, Giuseppe, Seneca, Elisa, Mansueto, Giovanna, Villani, Oreste, La Rocca, Francesco, D'Auria, Fiorella, Statuto, Teodora, Valvano, Luciana, Arruga, Francesca, Deaglio, Silvia, Efremov, Dimitar G, Sgambato, Alessandro, Laurenti, Luca

“…CD200, a transmembrane type Ia glycoprotein belonging to the immunoglobulin protein superfamily, is broadly expressed on a wide variety of cell types, such as…”
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Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia by De Luca, Luciana, D'Arena, Giovanni, Simeon, Vittorio, Trino, Stefania, Laurenzana, Ilaria, Caivano, Antonella, La Rocca, Francesco, Villani, Oreste, Mansueto, Giovanna, Deaglio, Silvia, Innocenti, Idanna, Laurenti, Luca, Molica, Stefano, Pietrantuono, Giuseppe, De Stradis, Angelo, Del Vecchio, Luigi, Musto, Pellegrino

“…Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease…”
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Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma by Amore, Alfonso, Galdiero, Massimiliano, Ciliberto, Gennaro, Giudice, Aldo, D’Ursi, Anna Maria, Barbieri, Antonio, Montella, Maurizio, Nocerino, Flavia, Capunzo, Mario, Crispo, Anna, D'Arena, Giovanni, Tecce, Mario Felice

“…Infection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries. Epidemiological reports indicate that…”
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The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands by Tissino, Erika, Gaglio, Annalisa, Nicolò, Antonella, Pozzo, Federico, Bittolo, Tamara, Rossi, Francesca Maria, Bomben, Riccardo, Nanni, Paola, Cattarossi, Ilaria, Zaina, Eva, Zimbo, Anna Maria, Ianna, Giulia, Capasso, Guido, Forestieri, Gabriela, Moia, Riccardo, Datta, Moumita, Härzschel, Andrea, Olivieri, Jacopo, D’Arena, Giovanni, Laurenti, Luca, Zaja, Francesco, Chiarenza, Annalisa, Palumbo, Giuseppe A., Martino, Enrica Antonia, Gentile, Massimo, Rossi, Davide, Gaidano, Gianluca, Del Poeta, Giovanni, Laureana, Roberta, Del Principe, Maria Ilaria, Maity, Palash C., Jumaa, Hassan, Hartmann, Tanja Nicole, Zucchetto, Antonella, Gattei, Valter

“…In chronic lymphocytic leukemia (CLL), survival of neoplastic cells depends on microenvironmental signals at lymphoid sites where the crosstalk between the…”
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Comparison of cardiovascular disease and cancer prevalence between Mediterranean and north European middle-aged populations (The Cilento on Ageing Outcomes Study and The Malmö Offspring Study) by Melander, Olle, Antonini, Paola, Ottosson, Filip, Brunkwall, Louise, Gallo, Widet, Nilsson, Peter M., Orho-Melander, Marju, Pacente, Gaetano, D’Arena, Giovanni, Di Somma, Salvatore

“…Mediterranean diet protects from both cardiovascular disease (CVD) and cancer. In the 1960s, Ancel Keys defined the concept of Mediterranean diet in the South…”
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T-Large Granular Lymphocytic Leukemia with Hepatosplenic T-Cell Lymphoma? A Rare Case of Simultaneous Neoplastic T-Cell Clones Highlighted by Flow Cytometry and Review of Literature by Libonati, Rossana, Soda, Michela, Statuto, Teodora, Valvano, Luciana, D'Auria, Fiorella, D'Arena, Giovanni, Pietrantuono, Giuseppe, Villani, Oreste, Mansueto, Giovanna Rosaria, D'Agostino, Simona, Di Somma, Massimo Dante, Telesca, Alessia, Vilella, Rocchina

“…Lymphoproliferative diseases are a heterogeneous set of malignant clonal proliferations of lymphocytes. Despite well-established diagnostic criteria, the…”
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Mutations in the 3' untranslated region of NOTCH1 are associated with low CD20 expression levels chronic lymphocytic leukemia by Bittolo, Tamara, Pozzo, Federico, Bomben, Riccardo, D'Agaro, Tiziana, Bravin, Vanessa, Bulian, Pietro, Rossi, Francesca Maria, Zucchetto, Antonella, Degan, Massimo, Macor, Paolo, D'Arena, Giovanni, Chiarenza, Annalisa, Zaja, Francesco, Pozzato, Gabriele, Di Raimondo, Francesco, Rossi, Davide, Gaidano, Gianluca, Del Poeta, Giovanni, Gattei, Valter, Dal Bo, Michele

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Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies by Musto, Pellegrino, Di Minno, Giovanni, Fenoglio, Daniela, Calapai, Gioacchino, Caraglia, Michele, De Feo, Vincenzo, Di Minno, Matteo Nicola Dario, Festa, Agostino, Coscia, Marta, Vitale, Candida, D'Arena, Giovanni, Laurenti, Luca

“…Regulatory T cells (Tregs) have a fundamental function in monitoring the immune homeostasis in healthy individuals. In cancer and, in particular, in…”
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